[FeFe] Group C3-hydrogenase Putative

This entry was last updated at: Feb. 9, 2018, 6:15 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group C3: Phosphatase-linked
Function Unconfirmed role. May serve as H2-sensors in regulatory cascades. Enzyme predicted to transfer H2-liberated electrons to PAS domain. Associated redox change may modulate activity of associated serine/threonine phosphatase or AAA-type ATPase domains. Members of this class are co-transcribed with fermentative hydrogenases and appear to regulate their transcription.
Activity H2-sensing?
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Widespread in anaerobic bacteria, including Firmicutes, Deltaproteobacteria, and Spirochaete
Genetic Organisation

Organisation 1: Ruminococcus albus (WP_002849014.1):


Organisation 2: Geobacter sulfurreducens (WP_014552161.1):

Architecture
Structures
    None
Subunits 1 or 3
Subunit description Organisation 1: HydS (catalytic subunit with PAS domain), HydP (serine/threonine phosphatase), HydT (thioredoxin)
Organisation 2: HydS fusion (catalytic subunit with PAS domain fused to AAA-type ATPase domain)
Catalytic site [FeFe]-centre
FeS clusters 2 [4Fe4S] clusters
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_003543335.1Desulfotomaculum nigrificans[FeFe] Group C3FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainNone
WP_004514179.1Geobacter metallireducens[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_006002638.1Desulfuromonas acetoxidans[FeFe] Group C3DeltaproteobacteriaDesulfovibrionalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_006928132.1Caldithrix abyssi[FeFe] Group C3CaldithrixCaldithrixalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with histidine kinase
WP_008413245.1Desulfotomaculum hydrothermale[FeFe] Group C3FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainNone
WP_010663847.1Marinilabilia salmonicolor[FeFe] Group C3BacteroidetesBacteroidalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_011342071.1Pelobacter carbinolicus[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_011393215.1Moorella thermoacetica[FeFe] Group C3FirmicutesThermoanaerobacteralesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_011393389.1Moorella thermoacetica[FeFe] Group C3FirmicutesThermoanaerobacteralesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_011940950.1Geobacter uraniireducens[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_012532230.1Geobacter bemidjiensis[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_012635244.1Halothermothrix orenii[FeFe] Group C3FirmicutesHalanaerobialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_012645645.1Geobacter daltonii[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_013119651.1Thermincola potens[FeFe] Group C3FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_013121809.1Thermincola potens[FeFe] Group C3FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_013406267.1Halanaerobium hydrogeniformans[FeFe] Group C3FirmicutesHalanaerobialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_013484024.1Ethanoligenens harbinense[FeFe] Group C3FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_013781007.1Mahella australiensis[FeFe] Group C3FirmicutesThermoanaerobacteralesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_013810321.1Desulfotomaculum carboxydivorans[FeFe] Group C3FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainNone
WP_013841414.1Desulfotomaculum ruminis[FeFe] Group C3FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainNone
WP_014186009.1Desulfosporosinus orientis[FeFe] Group C3FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_014296384.1Marinitoga piezophila[FeFe] Group C3ThermotogaeThermotogalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_014552161.1Geobacter sulfurreducens[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_014559402.1Ignavibacterium album[FeFe] Group C3IgnavibacteriaeIgnavibacterialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with histidine kinase
WP_015722465.1Geobacter sp. M18[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_015839082.1 Geobacter sp. M21[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_020675965.1Geopsychrobacter electrodiphilus[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_026841112.1Geobacter bremensis[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_028308065.1Desulfitibacter alkalitolerans[FeFe] Group C3FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_029918197.1Pelobacter seleniigenes[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_015839082.1Geobacter sp. M21[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_003493654.1Clostridium sporogenes[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_003493657.1Clostridium sporogenes[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_003543972.1Desulfotomaculum nigrificans[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_003868133.1Thermoanaerobacter ethanolicus[FeFe] Group C3FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_005487145.1Halanaerobium saccharolyticum[FeFe] Group C3FirmicutesHalanaerobialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_006524079.1Desulfotomaculum gibsoniae[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_006784034.1Turicibacter sanguinis[FeFe] Group C3FirmicutesErysipelotrichalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_007059414.1Clostridium carboxidivorans[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_007287482.1Intestinibacter bartlettii[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_007287485.1Intestinibacter bartlettii[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_008409712.1Desulfotomaculum hydrothermale[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_008410113.1Desulfotomaculum hydrothermale[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_008709061.1Synergistes sp. 3_1_syn1[FeFe] Group C3SynergistetesSynergistalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_008825904.1Haloplasma contractile[FeFe] Group C3TenericutesHaloplasmatalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_009610480.1Caldanaerobacter subterraneus[FeFe] Group C3FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_011877929.1Desulfotomaculum reducens[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_011878613.1Desulfotomaculum reducens[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_011928108.1Pelotomaculum thermopropionicum[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_012065100.1Alkaliphilus metalliredigens[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase

Literature

Genetics:

,

Physiology:

Biochemistry: