[FeFe] Group C3-hydrogenase Putative

This entry was last updated at: Feb. 9, 2018, 6:15 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group C3: Phosphatase-linked
Function Unconfirmed role. May serve as H2-sensors in regulatory cascades. Enzyme predicted to transfer H2-liberated electrons to PAS domain. Associated redox change may modulate activity of associated serine/threonine phosphatase or AAA-type ATPase domains. Members of this class are co-transcribed with fermentative hydrogenases and appear to regulate their transcription.
Activity H2-sensing?
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Widespread in anaerobic bacteria, including Firmicutes, Deltaproteobacteria, and Spirochaete
Genetic Organisation

Organisation 1: Ruminococcus albus (WP_002849014.1):


Organisation 2: Geobacter sulfurreducens (WP_014552161.1):

Architecture
Structures
    None
Subunits 1 or 3
Subunit description Organisation 1: HydS (catalytic subunit with PAS domain), HydP (serine/threonine phosphatase), HydT (thioredoxin)
Organisation 2: HydS fusion (catalytic subunit with PAS domain fused to AAA-type ATPase domain)
Catalytic site [FeFe]-centre
FeS clusters 2 [4Fe4S] clusters
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
AEM79842.1Thermoanaerobacter wiegelii[FeFe] Group C3FirmicutesThermoanaerobacteralesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
AIO18481.1Mollicutes bacterium HR1[FeFe] Group C3TenericutesMollicutesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_002568890.1Lachnoclostridium bolteae[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_002849014.1Ruminococcus albus[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_003493654.1Clostridium sporogenes[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_003493657.1Clostridium sporogenes[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_003499089.1Lachnoclostridium symbiosum[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_003507891.1Lachnoclostridium symbiosum[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_003543335.1Desulfotomaculum nigrificans[FeFe] Group C3FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainNone
WP_003543972.1Desulfotomaculum nigrificans[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_003868133.1Thermoanaerobacter ethanolicus[FeFe] Group C3FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_004081666.1Thermotoga maritima[FeFe] Group C3ThermotogaeThermotogalesSensorySensitive2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_004514179.1Geobacter metallireducens[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_004608289.1Lachnoclostridium scindens[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_004614045.1Tyzzerella nexilis[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_004629692.1Ruminiclostridium termitidis[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_005037180.1Holophaga foetida[FeFe] Group C3AcidobacteriaHolophagalesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_005487145.1Halanaerobium saccharolyticum[FeFe] Group C3FirmicutesHalanaerobialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_005659983.1Dethiosulfovibrio peptidovorans[FeFe] Group C3SynergistetesSynergistalesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_005996231.1Desulfovibrio fructosivorans[FeFe] Group C3DeltaproteobacteriaDesulfovibrionalesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_006002638.1Desulfuromonas acetoxidans[FeFe] Group C3DeltaproteobacteriaDesulfovibrionalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_006059864.1Holdemania filiformis[FeFe] Group C3FirmicutesErysipelotrichalesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_006301959.1Aminomonas paucivorans[FeFe] Group C3SynergistetesSynergistalesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_006442325.1Lachnoclostridium hylemonae[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_006524079.1Desulfotomaculum gibsoniae[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_006574746.1Pseudoflavonifractor capillosus[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_006778911.1Lachnoclostridium hathewayi[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_006784034.1Turicibacter sanguinis[FeFe] Group C3FirmicutesErysipelotrichalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_006874783.1Anaerotruncus colihominis[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_006928132.1Caldithrix abyssi[FeFe] Group C3CaldithrixCaldithrixalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with histidine kinase
WP_007059414.1Clostridium carboxidivorans[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_007287482.1Intestinibacter bartlettii[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_007287485.1Intestinibacter bartlettii[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_007290221.1Thermosinus carboxydivorans[FeFe] Group C3FirmicutesSelenomonadalesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_007715934.1Lachnoclostridium asparagiforme[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_007863168.1Lachnoclostridium citroniae[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_008409712.1Desulfotomaculum hydrothermale[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_008410113.1Desulfotomaculum hydrothermale[FeFe] Group C3FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_008413245.1Desulfotomaculum hydrothermale[FeFe] Group C3FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainNone
WP_008709061.1Synergistes sp. 3_1_syn1[FeFe] Group C3SynergistetesSynergistalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_008825904.1Haloplasma contractile[FeFe] Group C3TenericutesHaloplasmatalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_009137123.1Odoribacter laneus[FeFe] Group C3BacteroidetesBacteroidalesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_009610480.1Caldanaerobacter subterraneus[FeFe] Group C3FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase
WP_010250208.1Acetivibrio cellulolyticus[FeFe] Group C3FirmicutesClostridialesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_010663847.1Marinilabilia salmonicolor[FeFe] Group C3BacteroidetesBacteroidalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_011341577.1Pelobacter carbinolicus[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin
WP_011342071.1Pelobacter carbinolicus[FeFe] Group C3DeltaproteobacteriaDesulfuromonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_011393215.1Moorella thermoacetica[FeFe] Group C3FirmicutesThermoanaerobacteralesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_011393389.1Moorella thermoacetica[FeFe] Group C3FirmicutesThermoanaerobacteralesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with transcriptional activator
WP_011698701.1Syntrophobacter fumaroxidans[FeFe] Group C3DeltaproteobacteriaDesulfovibrionalesSensoryLabile3[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainPhosphatase, thioredoxin

Literature

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