This entry was last updated at: Feb. 9, 2018, 7:29 a.m.
Group | [FeFe]-hydrogenases |
Subgroup | [FeFe] Group A1: Prototypical |
Function | Fermentative or photobiological evolution of H2 using reduced ferredoxin as an electron donor. |
Activity | H2-evolution |
Oxygen tolerance | O2-labile |
Localisation | Cytosolic |
Ecosystem distribution | Anoxic waters, soils, and sediments, gastrointestinal tracts |
Taxonomic distribution | Widespread in anaerobic bacteria and unicellular eukaryotes |
Organisation 1: Chlamydomonas reinhardtii (XP_001693376.1):
Organisation 2: Trichomonas vaginalis (XP_001330775.1):
Organisation 3: Clostridium pasteurianum (WP_004455619.1):
Organisation 4: Desulfovibrio vulgaris (WP_010939057.1):
Organisation 5: Shewanella oneidensis (WP_011073665.1):
Organisation 6: Trichomonas vaginalis (XP_001580488.1):
Structures | |
Subunits | N/A |
Subunit description | HydA (catalytic subunit) In organisation 4 and 5, the catalytic subunit is split into a large subunit (HydA) and small subunit (HydS) In organisation 5, a cytochrome b subunit (HydH) is present In organisation 6, the hydrogenase domain is fused to a nitrate reductase or sulfite reductase domain |
Catalytic site | [FeFe]-centre |
FeS clusters | Organisation 1: Absent Organisation 2: 2 [4Fe4S] clusters Organisation 3: 3 [4Fe4S] clusters, 1 [2Fe2S] cluster Organisation 4: 2 [4Fe4S] clusters Organisation 5: 2 [4Fe4S] clusters Organisation 6: 3 [4Fe4S] clusters, 1 [2Fe2S] cluster |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_013823947.1 | Desulfotomaculum kuznetsovii | [FeFe] Group A1 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | Thioredoxin |
WP_011073665.1 | Shewanella oneidensis | [FeFe] Group A1 | Gammaproteobacteria | Alteromonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_011623989.1 | Shewanella sp. MR-4 | [FeFe] Group A1 | Gammaproteobacteria | Alteromonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_011641315.1 | Syntrophomonas wolfei | [FeFe] Group A1 | Firmicutes | Clostridiales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_011715875.1 | Shewanella sp. ANA-3 | [FeFe] Group A1 | Gammaproteobacteria | Alteromonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_012276514.1 | Shewanella halifaxensis | [FeFe] Group A1 | Gammaproteobacteria | Alteromonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_013175699.1 | Syntrophothermus lipocalidus | [FeFe] Group A1 | Firmicutes | Clostridiales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_013345564.1 | Ferrimonas balearica | [FeFe] Group A1 | Gammaproteobacteria | Alteromonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_013756852.1 | Thermodesulfobium narugense | [FeFe] Group A1 | Firmicutes | Thermoanaerobacterales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_013907122.1 | Thermodesulfatator indicus | [FeFe] Group A1 | Thermodesulfobacteria | Thermodesulfobacteriales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_013907125.1 | Thermodesulfatator indicus | [FeFe] Group A1 | Thermodesulfobacteria | Thermodesulfobacteriales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_014423937.1 | Selenomonas ruminantium | [FeFe] Group A1 | Firmicutes | Selenomonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_018703705.1 | Anaeromusa acidaminophila | [FeFe] Group A1 | Firmicutes | Selenomonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_022852507.1 | Thermodesulfatator atlanticus | [FeFe] Group A1 | Thermodesulfobacteria | Thermodesulfobacteriales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_022854721.1 | Thermodesulfobacterium thermophilum | [FeFe] Group A1 | Thermodesulfobacteria | Thermodesulfobacteriales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_023268563.1 | Shewanella decolorationis | [FeFe] Group A1 | Gammaproteobacteria | Alteromonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_024788990.1 | Lebetimonas sp. JH292 | [FeFe] Group A1 | Epsilonproteobacteria | Nautiliales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_025823167.1 | Shewanella marina | [FeFe] Group A1 | Gammaproteobacteria | Alteromonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_025888294.1 | Shewanella haliotis | [FeFe] Group A1 | Gammaproteobacteria | Alteromonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_026329186.1 | Zymophilus raffinosivorans | [FeFe] Group A1 | Firmicutes | Selenomonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_027938424.1 | Anaeroarcus burkinensis | [FeFe] Group A1 | Firmicutes | Selenomonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_028109440.1 | Ferrimonas futtsuensis | [FeFe] Group A1 | Gammaproteobacteria | Alteromonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_028116362.1 | Ferrimonas senticii | [FeFe] Group A1 | Gammaproteobacteria | Alteromonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_028768142.1 | Shewanella fidelis | [FeFe] Group A1 | Gammaproteobacteria | Alteromonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_028781324.1 | Shewanella sp. 38A_GOM-205m | [FeFe] Group A1 | Gammaproteobacteria | Alteromonadales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_028841196.1 | Thermodesulfobacterium hveragerdense | [FeFe] Group A1 | Thermodesulfobacteria | Thermodesulfobacteriales | Evolving | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit, cytochrome b |
WP_003493693.1 | Clostridium sporogenes | [FeFe] Group A1 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | Small subunit |
WP_005996594.1 | Desulfovibrio fructosivorans | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_009379319.1 | Bilophila sp. 4_1_30 | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_009380765.1 | Bilophila sp. 4_1_30 | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_010939057.1 | Desulfovibrio vulgaris | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_011366264.1 | Desulfovibrio alaskensis | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_011368163.1 | Desulfovibrio alaskensis | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_011697718.1 | Syntrophobacter fumaroxidans | [FeFe] Group A1 | Deltaproteobacteria | Syntrophobacterales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_012625129.1 | Desulfovibrio desulfuricans | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_013513265.1 | Desulfovibrio aespoeensis | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_014812866.1 | Desulfomonile tiedjei | [FeFe] Group A1 | Deltaproteobacteria | Syntrophobacterales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_015337634.1 | Desulfovibrio hydrothermalis | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_015851212.1 | Desulfovibrio salexigens | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_022663178.1 | Desulfovibrio longus | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_024933644.1 | Clostridium botulinum | [FeFe] Group A1 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | Small subunit |
WP_027176561.1 | Desulfovibrio aminophilus | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_027179345.1 | Desulfovibrio bastinii | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_027183226.1 | Desulfovibrio inopinatus | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_027191878.1 | Desulfovibrio putealis | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_027722058.1 | Desulfovibrio zosterae | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
WP_028586843.1 | Desulfocurvus vexinensis | [FeFe] Group A1 | Deltaproteobacteria | Desulfovibrionales | Evolving | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters | Small subunit |
XP_001318941.1 | Trichomonas vaginalis | [FeFe] Group A1 | Metamonada | Trichomonadida | Evolving | Labile | 1 | [FeFe]-centre | None, incomplete sequence |
WP_002568840.1 | Lachnoclostridium bolteae | [FeFe] Group A1 | Firmicutes | Clostridiales | Evolving | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters | None |
WP_002583070.1 | Clostridium butyricum | [FeFe] Group A1 | Firmicutes | Clostridiales | Evolving | Labile | 1 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | None |
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