Hydrogenase Classifier

NCBI Accession	Organism	Hydrogenase Class	Phylum	Order	Activity (Predicted)	Oxygen Tolerance (Predicted)	Subunits (Predicted)	Metal Centres (Predicted)	Accessory Subunits (Predicted)
WP_013559391.1	Anaerolinea thermophila	[NiFe] Group 3d	Chloroflexi	Anaerolineales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_013559677.1	Anaerolinea thermophila	[NiFe] Group 3d	Chloroflexi	Anaerolineales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_014434113.1	Caldilinea aerophila	[NiFe] Group 3d	Chloroflexi	Caldilineales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_015941206.1	Chloroflexus aggregans	[NiFe] Group 3d	Chloroflexi	Chloroflexales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_028457902.1	Chloroflexus sp. Y-396-1	[NiFe] Group 3d	Chloroflexi	Chloroflexales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_006562473.1	Oscillochloris trichoides	[NiFe] Group 3d	Chloroflexi	Chloroflexales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_012119893.1	Roseiflexus castenholzii	[NiFe] Group 3d	Chloroflexi	Chloroflexales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_011958239.1	Roseiflexus sp. RS-1	[NiFe] Group 3d	Chloroflexi	Chloroflexales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_010936594.1	Dehalococcoides mccartyi	[NiFe] Group 4e	Chloroflexi	Dehalococcoidales	Evolving	Sensitive	6	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, [FeS] protein
WP_013560598.1	Anaerolinea thermophila	[NiFe] Group 4g	Chloroflexi	Anaerolineales	Evolving	Sensitive	6	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, [FeS] protein
XP_001693376.1	Chlamydomonas reinhardtii	[FeFe] Group A1	Chlorophyta	Chlamydomonadales	Evolving	Labile	1	[FeFe]-centre	None
XP_001694503.1	Chlamydomonas reinhardtii	[FeFe] Group A1	Chlorophyta	Chlamydomonadales	Evolving	Labile	1	[FeFe]-centre	None
XP_002948483.1	Volvox carteri	[FeFe] Group A1	Chlorophyta	Volvocales	Evolving	Labile	1	[FeFe]-centre	None
XP_002956049.1	Volvox carteri	[FeFe] Group A1	Chlorophyta	Volvocales	Evolving	Labile	1	[FeFe]-centre	None
XP_005843810.1	Chlorella variabilis	[FeFe] Group A1	Chlorophyta	Chlorellales	Evolving	Labile	1	[FeFe]-centre	None
XP_005847147.1	Chlorella variabilis	[FeFe] Group A1	Chlorophyta	Chlorellales	Evolving	Labile	1	[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster	None
XP_005848612.1	Chlorella variabilis	[FeFe] Group A1	Chlorophyta	Chlorellales	Evolving	Labile	1	[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster	None
WP_027390843.1	Chrysiogenes arsenatis	[NiFe] Group 1b	Chrysiogenetes	Chrysiogenales	Anaerobic Uptake	Sensitive	3	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome
WP_013505701.1	Desulfurispirillum indicum	[NiFe] Group 1b	Chrysiogenetes	Chrysiogenales	Anaerobic Uptake	Sensitive	3	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome
WP_027388897.1	Chrysiogenes arsenatis	[NiFe] Group 3d	Chrysiogenetes	Chrysiogenales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_013506608.1	Desulfurispirillum indicum	[NiFe] Group 3d	Chrysiogenetes	Chrysiogenales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_015424900.1	Cloacimonas acidaminovorans	[FeFe] Group A3	Cloacimonetes	Unclassified	Bifurcating	Labile	1	[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster	NADH dehydrogenase, thioredoxin
WP_011822511.1	Hyperthermus butylicus	[NiFe] Group 1g	Crenarchaeota	Desulfurococcales	Anaerobic Uptake	Unknown	3	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b
WP_012123507.1	Ignicoccus hospitalis	[NiFe] Group 1g	Crenarchaeota	Desulfurococcales	Anaerobic Uptake	Unknown	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b, [FeS] protein
WP_014025627.1	Pyrolobus fumarii	[NiFe] Group 1g	Crenarchaeota	Desulfurococcales	Anaerobic Uptake	Unknown	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b, [FeS] protein
WP_011900768.1	Pyrobaculum arsenaticum	[NiFe] Group 1g	Crenarchaeota	Thermoproteales	Anaerobic Uptake	Unknown	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b, [FeS] protein
WP_011850254.1	Pyrobaculum calidifontis	[NiFe] Group 1g	Crenarchaeota	Thermoproteales	Anaerobic Uptake	Unknown	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b, [FeS] protein
WP_011761956.1	Pyrobaculum islandicum	[NiFe] Group 1g	Crenarchaeota	Thermoproteales	Anaerobic Uptake	Unknown	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b, [FeS] protein
WP_014346469.1	Pyrobaculum oguniense	[NiFe] Group 1g	Crenarchaeota	Thermoproteales	Anaerobic Uptake	Unknown	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b, [FeS] protein
WP_011752262.1	Thermofilum pendens	[NiFe] Group 1g	Crenarchaeota	Thermoproteales	Anaerobic Uptake	Unknown	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b, [FeS] protein
WP_020962524.1	Thermofilum sp. 1910b	[NiFe] Group 1g	Crenarchaeota	Thermoproteales	Anaerobic Uptake	Unknown	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b, [FeS] protein
WP_012349775.1	Thermoproteus neutrophilus	[NiFe] Group 1g	Crenarchaeota	Thermoproteales	Anaerobic Uptake	Unknown	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b, [FeS] protein
WP_014125970.1	Thermoproteus tenax	[NiFe] Group 1g	Crenarchaeota	Thermoproteales	Anaerobic Uptake	Unknown	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b, [FeS] protein
WP_013680997.1	Thermoproteus uzoniensis	[NiFe] Group 1g	Crenarchaeota	Thermoproteales	Anaerobic Uptake	Unknown	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b, [FeS] protein
WP_013337401.1	Vulcanisaeta distributa	[NiFe] Group 1g	Crenarchaeota	Thermoproteales	Anaerobic Uptake	Unknown	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b, [FeS] protein
WP_014512387.1	Sulfolobus islandicus	[NiFe] Group 1h	Crenarchaeota	Sulfolobales	Aerobic Uptake	Tolerant	3	[NiFe]-centre, 3 x [4Fe4S] clusters	[FeS] protein
WP_012020882.1	Metallosphaera sedula	[NiFe] Group 2e	Crenarchaeota	Sulfolobales	Anaerobic Uptake	Unknown	2	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	None
WP_009070398.1	Metallosphaera yellowstonensis	[NiFe] Group 2e	Crenarchaeota	Sulfolobales	Anaerobic Uptake	Unknown	2	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	None
WP_016729728.1	Sulfolobus islandicus	[NiFe] Group 2e	Crenarchaeota	Sulfolobales	Anaerobic Uptake	Unknown	2	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	None
WP_014737726.1	Thermogladius cellulolyticus	[NiFe] Group 3b	Crenarchaeota	Desulfurococcales	Bidirectional	Tolerant	4	[NiFe]-centre, 3 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_014558156.1	Fervidicoccus fontis	[NiFe] Group 3b	Crenarchaeota	Fervidicoccales	Bidirectional	Tolerant	4	[NiFe]-centre, 3 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_014558423.1	Fervidicoccus fontis	[NiFe] Group 4a	Crenarchaeota	Fervidicoccales	Evolving	Sensitive	6 or 9	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, two [FeS] proteins, (three antiporter subunits)
WP_011751858.1	Thermofilum pendens	[NiFe] Group 4a	Crenarchaeota	Thermoproteales	Evolving	Sensitive	6 or 9	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, two [FeS] proteins, (three antiporter subunits)
WP_014767907.1	Desulfurococcus fermentans	[NiFe] Group 4b	Crenarchaeota	Desulfurococcales	Evolving	Sensitive	13	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, two [FeS] proteins, seven MRP antiporter subunits, etc.
WP_012608688.1	Desulfurococcus kamchatkensis	[NiFe] Group 4b	Crenarchaeota	Desulfurococcales	Evolving	Sensitive	13	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, two [FeS] proteins, seven MRP antiporter subunits, etc.
WP_013561596.1	Desulfurococcus mucosus	[NiFe] Group 4b	Crenarchaeota	Desulfurococcales	Evolving	Sensitive	13	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, two [FeS] proteins, seven MRP antiporter subunits, etc.
WP_011839350.1	Staphylothermus marinus	[NiFe] Group 4b	Crenarchaeota	Desulfurococcales	Evolving	Sensitive	13	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, two [FeS] proteins, seven MRP antiporter subunits, etc.
WP_014737671.1	Thermogladius cellulolyticus	[NiFe] Group 4b	Crenarchaeota	Desulfurococcales	Evolving	Sensitive	13	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, two [FeS] proteins, seven MRP antiporter subunits, etc.
WP_013129492.1	Thermosphaera aggregans	[NiFe] Group 4g	Crenarchaeota	Desulfurococcales	Evolving	Sensitive	6	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, [FeS] protein
WP_013128928.1	Thermosphaera aggregans	[NiFe] Group 4b	Crenarchaeota	Desulfurococcales	Evolving	Sensitive	13	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, two [FeS] proteins, seven MRP antiporter subunits, etc.

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