This entry was last updated at: June 13, 2016, 11:11 a.m.
Group | [NiFe] Group 4: Respiratory H2-evolving [NiFe] hydrogenases |
Subgroup | [NiFe] Group 4e: Ferredoxin-coupled, Ech-type |
Function | Forms respiratory complex that couples oxidation of ferredoxinred to reduction of protons to H2 in acetoclastic methanogenesis. This process appears to be coupled to sodium or proton translocation through the transmembrane modules. The complex can also act in the reverse direction during hydrogenotrophic methanogenesis. |
Activity | Bidirectional |
Oxygen tolerance | O2-sensitive |
Localisation | Membrane-bound |
Ecosystem distribution | Anoxic soils and sediments, animal gastrointestinal tracts |
Taxonomic distribution | Encoded in multiple methanogenic orders and anaerobic bacteria |
e.g. Methanosarcina barkeri (WP_011305188.1):
Structures |
|
Subunits | 6 |
Subunit description | EchA (hydrogenase large subunit) EchC (hydrogenase small subunit) EchF (iron-sulfur subunit) EchB (NuoH-like transmembrane adaptor) EchA (NuoL-like transmembrane adaptor) EchD (NuoC-like transmembrane adaptor) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: Absent Distal: Absent |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_014323623.1 | Desulfovibrio desulfuricans | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_021758533.1 | Desulfovibrio gigas | [NiFe] Group 4e | Deltaproteobacteria | Desulfobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015336113.1 | Desulfovibrio hydrothermalis | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027182881.1 | Desulfovibrio inopinatus | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_022661459.1 | Desulfovibrio longus | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012749853.1 | Desulfovibrio magneticus | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_018125731.1 | Desulfovibrio oxyclinae | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015414775.1 | Desulfovibrio piezophilus | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027190463.1 | Desulfovibrio putealis | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015853104.1 | Desulfovibrio salexigens | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_007524167.1 | Desulfovibrio sp. A2 | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_020879492.1 | Desulfovibrio sp. X2 | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_010937737.1 | Desulfovibrio vulgaris | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027723401.1 | Desulfovibrio zosterae | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013638341.1 | Desulfurobacterium thermolithotrophum | [NiFe] Group 4e | Aquificae | Desulfurobacteriales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027716617.1 | Desulfuromonas sp. TF | [NiFe] Group 4e | Deltaproteobacteria | Desulfuromonadales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_007070913.1 | Dialister invisus | [NiFe] Group 4e | Firmicutes | Selenomonadales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_022106764.1 | Dialister sp. CAG:486 | [NiFe] Group 4e | Firmicutes | Selenomonadales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_008860581.1 | Dialister succinatiphilus | [NiFe] Group 4e | Firmicutes | Selenomonadales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015760641.1 | Eggerthella lenta | [NiFe] Group 4e | Actinobacteria | Coriobacteriales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_021900040.1 | Eggerthella sp. CAG:1427 | [NiFe] Group 4e | Actinobacteria | Coriobacteriales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_022184688.1 | Eggerthella sp. CAG:209 | [NiFe] Group 4e | Actinobacteria | Coriobacteriales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_022363091.1 | Eggerthella sp. CAG:298 | [NiFe] Group 4e | Actinobacteria | Coriobacteriales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013979777.1 | Eggerthella sp. YY7918 | [NiFe] Group 4e | Actinobacteria | Coriobacteriales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_016308760.1 | Enterorhabdus caecimuris | [NiFe] Group 4e | Actinobacteria | Coriobacteriales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_028026344.1 | Enterorhabdus mucosicola | [NiFe] Group 4e | Actinobacteria | Coriobacteriales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027871860.1 | Eubacterium cellulosolvens | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015536221.1 | Eubacterium cylindroides | [NiFe] Group 4e | Firmicutes | Erysipelotrichales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_026835345.1 | Eubacterium xylanophilum | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015720170.1 | Geobacter sp. M18 | [NiFe] Group 4e | Deltaproteobacteria | Desulfuromonadales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_011937735.1 | Geobacter uraniireducens | [NiFe] Group 4e | Deltaproteobacteria | Desulfuromonadales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012199760.1 | Lachnoclostridium phytofermentans | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027431522.1 | Lachnospira multipara | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_024789181.1 | Lebetimonas sp. JH292 | [NiFe] Group 4e | Epsilonproteobacteria | Nautiliales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012035507.1 | Methanocella arvoryzae | [NiFe] Group 4e | Euryarchaeota | Methanocellales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_014405402.1 | Methanocella conradii | [NiFe] Group 4e | Euryarchaeota | Methanocellales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012899275.1 | Methanocella paludicola | [NiFe] Group 4e | Euryarchaeota | Methanocellales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012899230.1 | Methanocella paludicola | [NiFe] Group 4e | Euryarchaeota | Methanocellales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_014867437.1 | Methanoculleus bourgensis | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_011843203.1 | Methanoculleus marisnigri | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_004039320.1 | Methanofollis liminatans | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_020449518.1 | Methanomassiliicoccus intestinalis | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_019176382.1 | Methanomassiliicoccus luminyensis | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_004077817.1 | Methanoplanus limicola | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013328417.1 | Methanoplanus petrolearius | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_011991040.1 | Methanoregula boonei | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015284201.1 | Methanoregula formicica | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_011305188.1 | Methanosarcina barkeri | [NiFe] Group 4e | Euryarchaeota | Methanosarcinales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_011034248.1 | Methanosarcina mazei | [NiFe] Group 4e | Euryarchaeota | Methanosarcinales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012619310.1 | Methanosphaerula palustris | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
Genetics:
Physiology:
Biochemistry: