[NiFe] Group 4e-hydrogenase

This entry was last updated at: June 13, 2016, 11:11 a.m.

Properties
Group [NiFe] Group 4: Respiratory H2-evolving [NiFe] hydrogenases
Subgroup [NiFe] Group 4e: Ferredoxin-coupled, Ech-type
Function Forms respiratory complex that couples oxidation of ferredoxinred to reduction of protons to H2 in acetoclastic methanogenesis. This process appears to be coupled to sodium or proton translocation through the transmembrane modules. The complex can also act in the reverse direction during hydrogenotrophic methanogenesis.
Activity Bidirectional
Oxygen tolerance O2-sensitive
Localisation Membrane-bound
Distribution
Ecosystem distribution Anoxic soils and sediments, animal gastrointestinal tracts
Taxonomic distribution Encoded in multiple methanogenic orders and anaerobic bacteria
Genetic Organisation

e.g. Methanosarcina barkeri (WP_011305188.1):

Architecture
Structures
    None
Subunits 6
Subunit description EchA (hydrogenase large subunit)
EchC (hydrogenase small subunit)
EchF (iron-sulfur subunit)
EchB (NuoH-like transmembrane adaptor)
EchA (NuoL-like transmembrane adaptor)
EchD (NuoC-like transmembrane adaptor)
Catalytic site [NiFe]-centre
FeS clusters Proximal: 4Cys[4Fe4S]
Medial: Absent
Distal: Absent
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_022739883.1Adlercreutzia equolifaciens[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_006235754.1Collinsella aerofaciens[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_022094158.1Collinsella sp. CAG:166[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_022349360.1Collinsella sp. CAG:398[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_006720658.1Collinsella stercoris[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_009142078.1Collinsella tanakaei[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_012803120.1Cryptobacterium curtum[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_022379545.1Cryptobacterium sp. CAG:338[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_015760641.1Eggerthella lenta[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_021900040.1Eggerthella sp. CAG:1427[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_022184688.1Eggerthella sp. CAG:209[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_022363091.1Eggerthella sp. CAG:298[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_013979777.1Eggerthella sp. YY7918[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_016308760.1Enterorhabdus caecimuris[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_028026344.1Enterorhabdus mucosicola[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_006361427.1Slackia exigua[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_012798463.1Slackia heliotrinireducens[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_009138996.1Slackia piriformis[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_009078628.1Slackia sp. CM382[NiFe] Group 4eActinobacteriaCoriobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_013537236.1Thermovibrio ammonificans[NiFe] Group 4eAquificaeDesulfobacteralesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_013638341.1Desulfurobacterium thermolithotrophum[NiFe] Group 4eAquificaeDesulfurobacterialesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_010936594.1Dehalococcoides mccartyi[NiFe] Group 4eChloroflexiDehalococcoidalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_020585229.1Desulfobacter curvatus[NiFe] Group 4eDeltaproteobacteriaDesulfobacteralesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_021758533.1Desulfovibrio gigas[NiFe] Group 4eDeltaproteobacteriaDesulfobacteralesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_028587759.1Desulfocurvus vexinensis[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_028576381.1Desulfomicrobium escambiense[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_028573897.1Desulfonatronovibrio hydrogenovorans[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_028572004.1Desulfonatronum lacustre[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_029967123.1Desulfonauticus sp. A7A[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_013515288.1Desulfovibrio aespoeensis[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_005986921.1Desulfovibrio africanus[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_020887613.1Desulfovibrio alkalitolerans[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_027178908.1Desulfovibrio bastinii[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_027187946.1Desulfovibrio cuneatus[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_012625292.1Desulfovibrio desulfuricans[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_014323623.1Desulfovibrio desulfuricans[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_015336113.1Desulfovibrio hydrothermalis[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_027182881.1Desulfovibrio inopinatus[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_022661459.1Desulfovibrio longus[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_012749853.1Desulfovibrio magneticus[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_018125731.1Desulfovibrio oxyclinae[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_015414775.1Desulfovibrio piezophilus[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_027190463.1Desulfovibrio putealis[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_015853104.1Desulfovibrio salexigens[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_007524167.1Desulfovibrio sp. A2[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_020879492.1Desulfovibrio sp. X2[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_010937737.1Desulfovibrio vulgaris[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_027723401.1Desulfovibrio zosterae[NiFe] Group 4eDeltaproteobacteriaDesulfovibrionalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_027716617.1Desulfuromonas sp. TF[NiFe] Group 4eDeltaproteobacteriaDesulfuromonadalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein
WP_015720170.1Geobacter sp. M18[NiFe] Group 4eDeltaproteobacteriaDesulfuromonadalesEvolvingSensitive6[NiFe]-centre, 1 x [4Fe4S] clustersNuoL, NuoH, NuoC, [FeS] protein

Literature

Genetics:

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Biochemistry: