This entry was last updated at: June 13, 2016, 11:11 a.m.
Group | [NiFe] Group 4: Respiratory H2-evolving [NiFe] hydrogenases |
Subgroup | [NiFe] Group 4e: Ferredoxin-coupled, Ech-type |
Function | Forms respiratory complex that couples oxidation of ferredoxinred to reduction of protons to H2 in acetoclastic methanogenesis. This process appears to be coupled to sodium or proton translocation through the transmembrane modules. The complex can also act in the reverse direction during hydrogenotrophic methanogenesis. |
Activity | Bidirectional |
Oxygen tolerance | O2-sensitive |
Localisation | Membrane-bound |
Ecosystem distribution | Anoxic soils and sediments, animal gastrointestinal tracts |
Taxonomic distribution | Encoded in multiple methanogenic orders and anaerobic bacteria |
e.g. Methanosarcina barkeri (WP_011305188.1):
Structures |
|
Subunits | 6 |
Subunit description | EchA (hydrogenase large subunit) EchC (hydrogenase small subunit) EchF (iron-sulfur subunit) EchB (NuoH-like transmembrane adaptor) EchA (NuoL-like transmembrane adaptor) EchD (NuoC-like transmembrane adaptor) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: Absent Distal: Absent |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_012376920.1 | Opitutus terrae | [NiFe] Group 4e | Verrucomicrobia | Opitutales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012969568.1 | Allochromatium vinosum | [NiFe] Group 4e | Gammaproteobacteria | Chromatiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_014777057.1 | Thiocystis violascens | [NiFe] Group 4e | Gammaproteobacteria | Chromatiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015282154.1 | Thioflavicoccus mobilis | [NiFe] Group 4e | Gammaproteobacteria | Chromatiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_010251151.1 | Acetivibrio cellulolyticus | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015738579.1 | Ammonifex degensii | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027399701.1 | Anaerovorax odorimutans | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027203889.1 | Butyrivibrio fibrisolvens | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_026651247.1 | Butyrivibrio proteoclasticus | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_026892028.1 | Clostridium aerotolerans | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_005213155.1 | Clostridium celatum | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027631079.1 | Clostridium cellobioparum | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015926708.1 | Clostridium cellulolyticum | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_014254276.1 | Clostridium clariflavum | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_024832561.1 | Clostridium josui | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_024346172.1 | Clostridium methoxybenzovorans | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_004618281.1 | Clostridium papyrosolvens | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_004628623.1 | Clostridium termitidis | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_019226287.1 | Dehalobacter sp. E1 | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_020490799.1 | Dehalobacter sp. FTH1 | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012302199.1 | Desulforudis audaxviator | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027871860.1 | Eubacterium cellulosolvens | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_026835345.1 | Eubacterium xylanophilum | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012199760.1 | Lachnoclostridium phytofermentans | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027431522.1 | Lachnospira multipara | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_028241974.1 | Pseudobutyrivibrio ruminis | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_028246016.1 | Pseudobutyrivibrio ruminis | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_028234750.1 | Pseudobutyrivibrio sp. MD2005 | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_003514863.1 | Ruminiclostridium thermocellum | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_007047619.1 | Subdoligranulum variabile | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013625216.1 | Syntrophobotulus glycolicus | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013174844.1 | Syntrophothermus lipocalidus | [NiFe] Group 4e | Firmicutes | Clostridiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015536221.1 | Eubacterium cylindroides | [NiFe] Group 4e | Firmicutes | Erysipelotrichales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_022790212.1 | Streptococcus pleomorphus | [NiFe] Group 4e | Firmicutes | Lactobacilliales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_007070913.1 | Dialister invisus | [NiFe] Group 4e | Firmicutes | Selenomonadales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_022106764.1 | Dialister sp. CAG:486 | [NiFe] Group 4e | Firmicutes | Selenomonadales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_008860581.1 | Dialister succinatiphilus | [NiFe] Group 4e | Firmicutes | Selenomonadales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_011024634.1 | Caldanaerobacter subterraneus | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_026486855.1 | Caldanaerobius polysaccharolyticus | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_029228227.1 | Caldicellulosiruptor acetigenus | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013403527.1 | Caldicellulosiruptor hydrothermalis | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013432390.1 | Caldicellulosiruptor kristjanssonii | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_014042067.1 | Caldicellulosiruptor lactoaceticus | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013290727.1 | Caldicellulosiruptor obsidiansis | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013411862.1 | Caldicellulosiruptor owensensis | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_011917066.1 | Caldicellulosiruptor saccharolyticus | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_018962513.1 | Coprothermobacter platensis | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015051201.1 | Thermacetogenium phaeum | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_003868941.1 | Thermoanaerobacter ethanolicus | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_019907186.1 | Thermoanaerobacter indiensis | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
Genetics:
Physiology:
Biochemistry: