[NiFe] Group 1c-hydrogenase

This entry was last updated at: March 2, 2017, 1:49 a.m.

Properties
Group [NiFe] Group 1: Respiratory H2-uptake [NiFe] hydrogenases
Subgroup [NiFe] Group 1c: Hyb-type
Function Hydrogenotrophic respiration using fumarate, sulfate, or metals as terminal electron acceptors. Route of electron transfer unresolved. Can also fermentatively evolve H2 under hypoxia.
Activity H2-uptake (unidirectional)
Oxygen tolerance O2-sensitive
Localisation Membrane-bound
Distribution
Ecosystem distribution Animal gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Widespread in Enterobacteria and various sulfate-reducing bacteria
Genetic Organisation

e.g. Escherichia coli (WP_021568771.1):

Architecture
Structures
    None
Subunits 4
Subunit description HybC (hydrogenase large subunit)
HybO (hydrogenase small subunit)
HybA (iron-sulfur protein and proposed physiological electron acceptor)
HybB (transmembrane protein of unresolved function)
Catalytic site [NiFe]-centre
FeS clusters Proximal: 4Cys[4Fe4S]
Medial: 3Cys[3Fe4S]
Distal: 3Cys1His[4Fe4S]
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_014064532.1Haemophilus parainfluenzae[NiFe] Group 1cGammaproteobacteriaPasteurellalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_007243608.1Haemophilus pittmaniae[NiFe] Group 1cGammaproteobacteriaPasteurellalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_005760858.1Pasteurella bettyae[NiFe] Group 1cGammaproteobacteriaPasteurellalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_022854121.1Thermodesulfatator atlanticus[NiFe] Group 1cThermodesulfobacteriaThermodesulfobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_013906919.1Thermodesulfatator indicus[NiFe] Group 1cThermodesulfobacteriaThermodesulfobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_013909681.1Thermodesulfobacterium geofontis[NiFe] Group 1cThermodesulfobacteriaThermodesulfobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_028840815.1Thermodesulfobacterium hveragerdense[NiFe] Group 1cThermodesulfobacteriaThermodesulfobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit

Literature

Genetics:

Physiology:

Biochemistry: