[NiFe] Group 1c-hydrogenase

This entry was last updated at: March 2, 2017, 1:49 a.m.

Properties
Group [NiFe] Group 1: Respiratory H2-uptake [NiFe] hydrogenases
Subgroup [NiFe] Group 1c: Hyb-type
Function Hydrogenotrophic respiration using fumarate, sulfate, or metals as terminal electron acceptors. Route of electron transfer unresolved. Can also fermentatively evolve H2 under hypoxia.
Activity H2-uptake (unidirectional)
Oxygen tolerance O2-sensitive
Localisation Membrane-bound
Distribution
Ecosystem distribution Animal gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Widespread in Enterobacteria and various sulfate-reducing bacteria
Genetic Organisation

e.g. Escherichia coli (WP_021568771.1):

Architecture
Structures
    None
Subunits 4
Subunit description HybC (hydrogenase large subunit)
HybO (hydrogenase small subunit)
HybA (iron-sulfur protein and proposed physiological electron acceptor)
HybB (transmembrane protein of unresolved function)
Catalytic site [NiFe]-centre
FeS clusters Proximal: 4Cys[4Fe4S]
Medial: 3Cys[3Fe4S]
Distal: 3Cys1His[4Fe4S]
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_010941450.1Geobacter sulfurreducens[NiFe] Group 1cDeltaproteobacteriaDesulfobacteralesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_011938839.1Geobacter uraniireducens[NiFe] Group 1cDeltaproteobacteriaDesulfuromonadalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_022851983.1Geovibrio sp. L21-Ace-BES[NiFe] Group 1cDeferribacteresDeferribacteralesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_005638557.1Haemophilus haemolyticus[NiFe] Group 1cGammaproteobacteriaPasteurellalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_014064532.1Haemophilus parainfluenzae[NiFe] Group 1cGammaproteobacteriaPasteurellalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_007243608.1Haemophilus pittmaniae[NiFe] Group 1cGammaproteobacteriaPasteurellalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_004092218.1Hafnia alvei[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_011525039.1Koribacter versatilis[NiFe] Group 1cAcidobacteriaUnclassifiedAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_007370146.1Kosakonia radicincitans[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_026199142.1Lamprocystis purpurea[NiFe] Group 1cGammaproteobacteriaChromatialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_027275754.1Leminorella grimontii[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_011714122.1Magnetococcus marinus[NiFe] Group 1cAlphaproteobacteriaMagnetococcalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_024080419.1Magnetospirillum gryphiswaldense[NiFe] Group 1cAlphaproteobacteriaRhodospirillalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_011384056.1Magnetospirillum magneticum[NiFe] Group 1cAlphaproteobacteriaRhodospirillalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_008620025.1Magnetospirillum sp. SO-1[NiFe] Group 1cAlphaproteobacteriaRhodospirillalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_011201506.1Mannheimia succiniciproducens[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_004236380.1Morganella morganii[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_005760858.1Pasteurella bettyae[NiFe] Group 1cGammaproteobacteriaPasteurellalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_011092818.1Pectobacterium atrosepticum[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_010863700.1Plesiomonas shigelloides[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_023580917.1Proteus hauseri[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_004248989.1Proteus mirabilis[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_006535185.1Proteus penneri[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_006659162.1Providencia alcalifaciens[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_008912430.1Providencia burhodogranariea[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_004257943.1Providencia rettgeri[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_006814152.1 Providencia rustigianii[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_008916675.1Providencia sneebia[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_011466351.1Rhodoferax ferrireducens[NiFe] Group 1cBetaproteobacteriaBurkholderialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_000083035.1Salmonella bongori[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_023228387.1Salmonella enterica[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_029132834.1Sedimenticola selenatireducens[NiFe] Group 1cGammaproteobacteriaAlteromonadalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_024528473.1Serratia fonticola[NiFe] Group 1cGammaproteobacteriaAeromonadalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_000083052.1Shigella boydii[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_005020299.1Shigella dysenteriae[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_000083081.1Shigella flexneri[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_000083066.1Shigella sonnei[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_002443827.1Shimwellia blattae[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_011688559.1Solibacter usitatus[NiFe] Group 1cAcidobacteriaSolibacteralesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_009206448.1Sulfuricella denitrificans[NiFe] Group 1cBetaproteobacteriaHydrogenophilalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_004378930.1Thauera phenylacetica[NiFe] Group 1cBetaproteobacteriaRhodocyclalesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_022854121.1Thermodesulfatator atlanticus[NiFe] Group 1cThermodesulfobacteriaThermodesulfobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_013906919.1Thermodesulfatator indicus[NiFe] Group 1cThermodesulfobacteriaThermodesulfobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_013909681.1Thermodesulfobacterium geofontis[NiFe] Group 1cThermodesulfobacteriaThermodesulfobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_028840815.1Thermodesulfobacterium hveragerdense[NiFe] Group 1cThermodesulfobacteriaThermodesulfobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_013537874.1Thermovibrio ammonificans[NiFe] Group 1cAquificaeDesulfurobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_014780162.1Thiocystis violascens[NiFe] Group 1cGammaproteobacteriaChromatialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_009150983.1Thiorhodovibrio sp. 970[NiFe] Group 1cGammaproteobacteriaChromatialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_004703021.1Yersinia aldovae[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit
WP_005275315.1Yersinia bercovieri[NiFe] Group 1cGammaproteobacteriaEnterobacterialesAnaerobic UptakeSensitive4[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster[FeS] protein, TM subunit

Literature

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