[FeFe] Group C2-hydrogenase Putative

This entry was last updated at: Feb. 9, 2018, 6:15 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group C2: Chemotactic
Function Unconfirmed role. May serve as H2-sensors in regulatory cascades. Enzyme predicted to transfer H2-liberated electrons to PAS domain. Associated redox change may modulate activity of associated methyl-accepting chemotaxis proteins or diguanylate cyclases in turn leading to regulation of cellular motility.
Activity H2-sensing?
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Encoded in anaerobic bacteria, including Firmicutes and Spirochaetes
Genetic Organisation

Organisation 1: Clostridium lundense (WP_027626440.1):


Organisation 2: Desulfosporosinus orientis (WP_014186347.1):

Architecture
Structures
    None
Subunits 1
Subunit description Organisation 1: HydS fusion (catalytic subunit with PAS domain fused to methyl-accepting chemotaxis protein domain)
Organisation 2: HydS fusion (catalytic subunit with PAS domain fused to diguanylate cyclase domain)
Catalytic site [FeFe]-centre
FeS clusters 2 [4Fe4S] clusters
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_002848484.1Ruminococcus albus[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_004064152.1Eubacterium plexicaudatum[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_009618950.1Desulfosporosinus sp. OT[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with diguanylate cyclase
WP_010251391.1Acetivibrio cellulolyticus[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_011640458.1Syntrophomonas wolfei[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with histidine kinase
WP_013623612.1Syntrophobotulus glycolicus[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_014080084.1Roseburia hominis[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_014184511.1Desulfosporosinus orientis[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_014186347.1Desulfosporosinus orientis[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with diguanylate cyclase
WP_014186754.1Desulfosporosinus orientis[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with histidine kinase
WP_014903221.1Desulfosporosinus meridiei[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_015560495.1Roseburia intestinalis[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_027398671.1Anaerovorax odorimutans[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_027626440.1Clostridium lundense[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_028517519.1Ruminococcus flavefaciens[FeFe] Group C2FirmicutesClostridialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_007957068.1Pelosinus fermentans[FeFe] Group C2FirmicutesSelenomonadalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainNone
WP_013255981.1Spirochaeta smaragdinae[FeFe] Group C2SpirochaetesSpirochaetalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_013314414.1Spirochaeta thermophila[FeFe] Group C2SpirochaetesSpirochaetalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_013701174.1Treponema succinifaciens[FeFe] Group C2SpirochaetesSpirochaetalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_013757426.1Treponema brennaborense[FeFe] Group C2SpirochaetesSpirochaetalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_013969799.1Treponema caldaria[FeFe] Group C2SpirochaetesSpirochaetalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_015709814.1Treponema azotonutricium[FeFe] Group C2SpirochaetesSpirochaetalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with histidine kinase
WP_015713064.1Treponema azotonutricium[FeFe] Group C2SpirochaetesSpirochaetalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_022931679.1Treponema bryantii[FeFe] Group C2SpirochaetesSpirochaetalesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein
WP_013907653.1Thermodesulfatator indicus[FeFe] Group C2ThermodesulfobacteriaThermodesulfobacterialesSensoryLabile1[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainFusion with methyl-accepting chemotaxis protein

Literature

Genetics: