[FeFe] Group C1-hydrogenase Putative

This entry was last updated at: Feb. 9, 2018, 6:15 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group C1: Histidine kinase-linked
Function Unconfirmed role. May serve as H2-sensors in regulatory cascades. Enzyme predicted to transfer H2-liberated electrons to PAS domain. Associated redox change may modulate activity of associated histidine kinase and in turn transcription if other hydrogenases.
Activity H2-sensing?
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Encoded in anaerobic bacteria, including Firmicutes and Bacteroidetes
Genetic Organisation

e.g. Acetobacterium woodii (WP_014357055.1):

Architecture
Structures
    None
Subunits 2
Subunit description HydS (catalytic subunit with PAS domain)
HydK (histidine kinase)
Catalytic site [FeFe]-centre
FeS clusters 2 [4Fe4S] clusters
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_028991495.1Thermoanaerobacter thermocopriae[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_028729380.1Parabacteroides gordonii[FeFe] Group C1BacteroidetesBacteroidalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_028308072.1Desulfitibacter alkalitolerans[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_027717491.1Desulfovirgula thermocuniculi[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_027642172.1Lachnoclostridium clostridioforme[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_027629168.1Ruminiclostridium cellobioparum[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_027364040.1Desulfotomaculum alcoholivorax[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_027355352.1Desulfotomaculum thermocisternum[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_027338883.1Halonatronum saccharophilum[FeFe] Group C1FirmicutesHalanaerobialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_026894022.1Clostridiisalibacter paucivorans[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_026893765.1Clostridiisalibacter paucivorans[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_026485859.1Caldanaerobius polysaccharolyticus[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_026475068.1Alkaliflexus imshenetskii[FeFe] Group C1BacteroidetesBacteroidalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_026393511.1Acetobacterium dehalogenans[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_021739962.1Eubacterium ramulus[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_021167205.1Sporomusa ovata[FeFe] Group C1FirmicutesSelenomonadalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_019541391.1Proteiniphilum acetatigenes[FeFe] Group C1BacteroidetesBacteroidalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_018962522.1Coprothermobacter platensis[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_018660455.1Thermobrachium celere[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_018247867.1Orenia marismortui[FeFe] Group C1FirmicutesHalanaerobialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_018084276.1Desulfurispora thermophila[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_016777702.1Anaerophaga thermohalophila[FeFe] Group C1BacteroidetesBacteroidalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_015907773.1Caldicellulosiruptor bescii[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_015513457.1Coprococcus catus[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_015358348.1Ruminiclostridium stercorarium[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_015327627.1Halobacteroides halobius[FeFe] Group C1FirmicutesHalanaerobialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_014758976.1Thermoanaerobacterium saccharolyticum[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_014357055.1Acetobacterium woodii[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_014254572.1Ruminiclostridium clariflavum[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_014163756.1Thermovirga lienii[FeFe] Group C1SynergistetesSynergistalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_014062652.1Thermoanaerobacter wiegelii[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013823363.1Desulfotomaculum kuznetsovii[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013788354.1Thermoanaerobacterium xylanolyticum[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013780872.1Mahella australiensis[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013778946.1Tepidanaerobacter acetatoxydans[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013657399.1Cellulosilyticum lentocellum[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013610546.1Odoribacter splanchnicus[FeFe] Group C1BacteroidetesBacteroidalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013430365.1Caldicellulosiruptor kronotskyensis[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013412025.1 Caldicellulosiruptor owensensis[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013412025.1Caldicellulosiruptor owensensis[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013406358.1Halanaerobium hydrogeniformans[FeFe] Group C1FirmicutesHalanaerobialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013403323.1Caldicellulosiruptor hydrothermalis[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013379176.1Eubacterium limosum[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013297601.1Thermoanaerobacterium thermosaccharolyticum[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013290556.1Caldicellulosiruptor obsidiansis[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013273980.1Lachnoclostridium saccharolyticum[FeFe] Group C1FirmicutesClostridialesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_013150113.1Thermoanaerobacter mathranii[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_012994906.1Thermoanaerobacter italicus[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_012939176.1Acidaminococcus fermentans[FeFe] Group C1FirmicutesSelenomonadalesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase
WP_012543804.1Coprothermobacter proteolyticus[FeFe] Group C1FirmicutesThermoanaerobacteralesSensoryLabile2[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domainHistidine kinase

Literature

Genetics: