Hydrogenase Classifier - [FeFe] Group C1

Sequences in this class

NCBI Accession	Organism	Hydrogenase Class	Phylum	Order	Activity (Predicted)	Oxygen Tolerance (Predicted)	Subunits (Predicted)	Metal Centres (Predicted)	Accessory Subunits (Predicted)
WP_002572006.1	Lachnoclostridium bolteae	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_003512576.1	Ruminiclostridium thermocellum	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_003534146.1	Ruminiclostridium leptum	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_003871510.1	Thermoanaerobacter ethanolicus	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_004401673.1	Thermoanaerobacter thermohydrosulfuricus	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_004608279.1	Lachnoclostridium scindens	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_004626210.1	Ruminiclostridium termitidis	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_005643245.1	Parabacteroides merdae	[FeFe] Group C1	Bacteroidetes	Bacteroidales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_006521135.1	Desulfotomaculum gibsoniae	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_006570151.1	Thermoanaerobacter siderophilus	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_006573282.1	Pseudoflavonifractor capillosus	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_006778972.1	Lachnoclostridium hathewayi	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_007288806.1	Thermosinus carboxydivorans	[FeFe] Group C1	Firmicutes	Selenomonadales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_007656801.1	Parabacteroides goldsteinii	[FeFe] Group C1	Bacteroidetes	Bacteroidales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_007862856.1	Lachnoclostridium citroniae	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_008157723.1	Parabacteroides johnsonii	[FeFe] Group C1	Bacteroidetes	Bacteroidales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_008909343.1	Caloramator australicus	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_009145644.1	Phascolarctobacterium succinatutens	[FeFe] Group C1	Firmicutes	Selenomonadales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_009609830.1	Caldanaerobacter subterraneus	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_010251919.1	Acetivibrio cellulolyticus	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_010665314.1	Marinilabilia salmonicolor	[FeFe] Group C1	Bacteroidetes	Bacteroidales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_012064286.1	Alkaliphilus metalliredigens	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_012446583.1	Natranaerobius thermophilus	[FeFe] Group C1	Firmicutes	Natranaerobiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_012543804.1	Coprothermobacter proteolyticus	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_012939176.1	Acidaminococcus fermentans	[FeFe] Group C1	Firmicutes	Selenomonadales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_012994906.1	Thermoanaerobacter italicus	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013150113.1	Thermoanaerobacter mathranii	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013273980.1	Lachnoclostridium saccharolyticum	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013290556.1	Caldicellulosiruptor obsidiansis	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013297601.1	Thermoanaerobacterium thermosaccharolyticum	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013379176.1	Eubacterium limosum	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013403323.1	Caldicellulosiruptor hydrothermalis	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013406358.1	Halanaerobium hydrogeniformans	[FeFe] Group C1	Firmicutes	Halanaerobiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013412025.1	Caldicellulosiruptor owensensis	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013430365.1	Caldicellulosiruptor kronotskyensis	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013610546.1	Odoribacter splanchnicus	[FeFe] Group C1	Bacteroidetes	Bacteroidales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013657399.1	Cellulosilyticum lentocellum	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013778946.1	Tepidanaerobacter acetatoxydans	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013780872.1	Mahella australiensis	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013788354.1	Thermoanaerobacterium xylanolyticum	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_013823363.1	Desulfotomaculum kuznetsovii	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_014062652.1	Thermoanaerobacter wiegelii	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_014163756.1	Thermovirga lienii	[FeFe] Group C1	Synergistetes	Synergistales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_014254572.1	Ruminiclostridium clariflavum	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_014357055.1	Acetobacterium woodii	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_014758976.1	Thermoanaerobacterium saccharolyticum	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_015327627.1	Halobacteroides halobius	[FeFe] Group C1	Firmicutes	Halanaerobiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_015358348.1	Ruminiclostridium stercorarium	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_015513457.1	Coprococcus catus	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_015907773.1	Caldicellulosiruptor bescii	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase

Group	[FeFe]-hydrogenases
Subgroup	[FeFe] Group C1: Histidine kinase-linked
Function	Unconfirmed role. May serve as H₂-sensors in regulatory cascades. Enzyme predicted to transfer H₂-liberated electrons to PAS domain. Associated redox change may modulate activity of associated histidine kinase and in turn transcription if other hydrogenases.
Activity	H₂-sensing?
Oxygen tolerance	O₂-labile
Localisation	Cytosolic

Ecosystem distribution	Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution	Encoded in anaerobic bacteria, including Firmicutes and Bacteroidetes

Structures	None
Subunits	2
Subunit description	HydS (catalytic subunit with PAS domain) HydK (histidine kinase)
Catalytic site	[FeFe]-centre
FeS clusters	2 [4Fe4S] clusters

[FeFe] Group C1-hydrogenase Putative

Literature