[FeFe] Group B-hydrogenase Putative

This entry was last updated at: Feb. 9, 2018, 6:17 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group B: Colonic-type
Function Unconfirmed role. Indirect evidence suggests the hydrogenase is involved in hydrogenogenic fermentation. It may couple reoxidation of ferredoxinred to the evolution of H2.
Activity H2-evolution?
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Widespread in colonic Bacteroides, Clostridia, and Actinobacteria
Genetic Organisation

Organisation 1: Clostridium pasteurianum (WP_023976023.1):


Organisation 2: Clostridium carboxyidovorans (WP_007061531.1):

Architecture
Structures
    None
Subunits 1
Subunit description HydM (catalytic subunit)
Catalytic site [FeFe]-centre
FeS clusters Organisation 1: 2 [4Fe4S] clusters
Organisation 2: 3 [4Fe4S] clusters, 1 [2Fe2S] cluste
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_014015718.1Megasphaera elsdenii[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014079355.1Roseburia hominis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014080018.1Roseburia hominis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014115957.1Oscillibacter valericigenes[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014128295.1Acidaminococcus intestini[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014261748.1Filifactor alocis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014270720.1Sphaerochaeta pleomorpha[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014299406.1Bacteroides fragilis[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014487517.1Brachyspira intermedia[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014553742.1Halanaerobium praevalens[FeFe] Group BFirmicutesHalanaerobialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014553922.1Halanaerobium praevalens[FeFe] Group BFirmicutesHalanaerobialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014758430.1Thermoanaerobacterium saccharolyticum[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014792620.1Desulfitobacterium dehalogenans[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014792843.1Desulfitobacterium dehalogenans[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014904712.1Desulfosporosinus meridiei[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015261135.1Desulfitobacterium dichloroeliminans[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015325789.1Halobacteroides halobius[FeFe] Group BFirmicutesHalanaerobialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_015326565.1Halobacteroides halobius[FeFe] Group BFirmicutesHalanaerobialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015359535.1Ruminiclostridium stercorarium[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_015360284.1Ruminiclostridium stercorarium[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015390585.1Clostridium saccharoperbutylacetonicum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015393395.1Clostridium saccharoperbutylacetonicum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015515272.1Coprococcus catus[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_015518171.1Ruminiclostridium siraeum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_015529112.1Lachnoclostridium torques[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015560436.1Roseburia intestinalis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_015710040.1Treponema azotonutricium[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_015757276.1Desulfotomaculum acetoxidans[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015778292.1Anaerococcus prevotii[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015869123.1Kosmotoga olearia[FeFe] Group BThermotogaeThermotogalesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015943050.1Desulfitobacterium hafniense[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015943139.1Desulfitobacterium hafniense[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_016146243.1Butyricicoccus pullicaecorum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_016147607.1Butyricicoccus pullicaecorum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_016205726.1Clostridium sartagoforme[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_016206137.1Clostridium sartagoforme[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_016266912.1Bacteroides thetaiotaomicron[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_017414827.1Clostridium tunisiense[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_017751925.1Clostridium tyrobutyricum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_017753183.1Clostridium tyrobutyricum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_018086727.1Desulfurispora thermophila[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_018247956.1Orenia marismortui[FeFe] Group BFirmicutesHalanaerobialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_018248337.1Orenia marismortui[FeFe] Group BFirmicutesHalanaerobialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_018338302.1Butyricimonas synergistica[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_018357720.1Porphyromonas levii[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_018526486.1Spirochaeta alkalica[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_018703126.1Anaeromusa acidaminophila[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_019554692.1Zymophilus raffinosivorans[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centreNone
WP_019880475.1Succinispira mobilis[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_019893070.1Allobaculum stercoricanis[FeFe] Group BFirmicutesErysipelotrichalesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone

Literature

Genetics:

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Physiology: