[FeFe] Group B-hydrogenase Putative

This entry was last updated at: Feb. 9, 2018, 6:17 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group B: Colonic-type
Function Unconfirmed role. Indirect evidence suggests the hydrogenase is involved in hydrogenogenic fermentation. It may couple reoxidation of ferredoxinred to the evolution of H2.
Activity H2-evolution?
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Widespread in colonic Bacteroides, Clostridia, and Actinobacteria
Genetic Organisation

Organisation 1: Clostridium pasteurianum (WP_023976023.1):


Organisation 2: Clostridium carboxyidovorans (WP_007061531.1):

Architecture
Structures
    None
Subunits 1
Subunit description HydM (catalytic subunit)
Catalytic site [FeFe]-centre
FeS clusters Organisation 1: 2 [4Fe4S] clusters
Organisation 2: 3 [4Fe4S] clusters, 1 [2Fe2S] cluste
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_014063301.1Thermoanaerobacter wiegelii[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterPhosphatase
AIO18483.1Mollicutes bacterium HR1[FeFe] Group BTenericutesMollicutesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_002568888.1Lachnoclostridium bolteae[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_002570587.1Lachnoclostridium bolteae[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_002580023.1Clostridium butyricum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_002582769.1Clostridium butyricum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_002704855.1Treponema saccharophilum[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_002843191.1Peptostreptococcus anaerobius[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_002845087.1Peptostreptococcus anaerobius[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_002848990.1Ruminococcus albus[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_003148188.1Atopobium rimae[FeFe] Group BActinobacteriaCoriobacterialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_003492333.1Clostridium sporogenes[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_003495774.1Clostridium sporogenes[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_003530568.1Ruminiclostridium leptum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_003532170.1Ruminiclostridium leptum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_003540297.1Desulfotomaculum nigrificans[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_004052440.1Eubacterium plexicaudatum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_004054251.1Eubacterium plexicaudatum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_004093662.1Acetonema longum[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_004099977.1Acetonema longum[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_004307174.1Bacteroides ovatus[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_004330064.1Alistipes putredinis[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_004602330.1Eubacterium cellulosolvens[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_004605002.1Lachnoclostridium scindens[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_004610270.1Erysipelatoclostridium spiroforme[FeFe] Group BFirmicutesErysipelotrichalesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_004611414.1Tyzzerella nexilis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_004613839.1Tyzzerella nexilis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_004627876.1Ruminiclostridium termitidis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_004800637.1Erysipelatoclostridium dolichum[FeFe] Group BFirmicutesErysipelotrichalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_004817153.1Anaerococcus hydrogenalis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_004823125.1Peptoniphilus indolicus[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_004836902.1Anaerococcus tetradius[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_004840268.1Lachnoclostridium gnavus[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_005210787.1Clostridium celatum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_005210847.1Clostridium celatum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_005364906.1Peptoclostridium yurii[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_005487149.1Halanaerobium saccharolyticum[FeFe] Group BFirmicutesHalanaerobialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_005600915.1Butyrivibrio crossotus[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_005679640.1Bacteroides caccae[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_005836589.1Bacteroides uniformis[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_005929426.1Bacteroides salyersiae[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_005941153.1Bacteroides massiliensis[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_005944276.1Faecalibacterium prausnitzii[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_006009278.1Desulfovibrio piger[FeFe] Group BDeltaproteobacteriaDesulfovibrionalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_006190671.1Selenomonas sputigena[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_006352873.1Ruminiclostridium methylpentosum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_006442603.1Lachnoclostridium hylemonae[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_006520976.1Desulfotomaculum gibsoniae[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_006568603.1Anaerostipes caccae[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_006571748.1Pseudoflavonifractor capillosus[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone

Literature

Genetics:

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Physiology: