Hydrogenase Classifier

NCBI Accession	Organism	Hydrogenase Class	Phylum	Order	Activity (Predicted)	Oxygen Tolerance (Predicted)	Subunits (Predicted)	Metal Centres (Predicted)	Accessory Subunits (Predicted)
WP_027722757.1	Desulfovibrio zosterae	[NiFe] Group 1a	Deltaproteobacteria	Desulfovibrionales	Anaerobic Uptake	Sensitive	3	[NiFe]-centre, 3 x [4Fe4S] clusters	Cytochrome
WP_027722919.1	Desulfovibrio zosterae	[NiFe] Group 1b	Deltaproteobacteria	Desulfovibrionales	Anaerobic Uptake	Sensitive	3	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome
WP_027723401.1	Desulfovibrio zosterae	[NiFe] Group 4e	Deltaproteobacteria	Desulfovibrionales	Evolving	Sensitive	6	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, [FeS] protein
WP_027717485.1	Desulfovirgula thermocuniculi	[FeFe] Group A3	Firmicutes	Thermoanaerobacterales	Bifurcating	Labile	3	[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster	NADH dehydrogenase, thioredoxin
WP_027718652.1	Desulfovirgula thermocuniculi	[FeFe] Group A3	Firmicutes	Thermoanaerobacterales	Bifurcating	Labile	3	[FeFe]-centre, 3 x [4Fe4S] clusters, 2 x [2Fe2S] cluster	NADH dehydrogenase, thioredoxin
WP_027717491.1	Desulfovirgula thermocuniculi	[FeFe] Group C1	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_027718651.1	Desulfovirgula thermocuniculi	[FeFe] Group C3	Firmicutes	Thermoanaerobacterales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Phosphatase
WP_025391229.1	Desulfurella acetivorans	[NiFe] Group 1b	Deltaproteobacteria	Desulfurellales	Anaerobic Uptake	Sensitive	3	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome
WP_013505701.1	Desulfurispirillum indicum	[NiFe] Group 1b	Chrysiogenetes	Chrysiogenales	Anaerobic Uptake	Sensitive	3	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome
WP_013506608.1	Desulfurispirillum indicum	[NiFe] Group 3d	Chrysiogenetes	Chrysiogenales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_018084282.1	Desulfurispora thermophila	[FeFe] Group A3	Firmicutes	Clostridiales	Bifurcating	Labile	3	[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster	NADH dehydrogenase, thioredoxin
WP_018085930.1	Desulfurispora thermophila	[FeFe] Group A3	Firmicutes	Clostridiales	Bifurcating	Labile	3	[FeFe]-centre, 3 x [4Fe4S] clusters, 2 x [2Fe2S] cluster	NADH dehydrogenase, thioredoxin
WP_018086225.1	Desulfurispora thermophila	[FeFe] Group A3	Firmicutes	Clostridiales	Bifurcating	Labile	3	[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster	NADH dehydrogenase, thioredoxin
WP_018086727.1	Desulfurispora thermophila	[FeFe] Group B	Firmicutes	Clostridiales	Evolving	Labile	1	[FeFe]-centre, 2 x [4Fe4S] clusters	None
WP_018084276.1	Desulfurispora thermophila	[FeFe] Group C1	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Histidine kinase
WP_018085928.1	Desulfurispora thermophila	[FeFe] Group C3	Firmicutes	Clostridiales	Sensory	Labile	2	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Phosphatase
WP_013162757.1	Desulfurivibrio alkaliphilus	[NiFe] Group 1a	Deltaproteobacteria	Desulfobacterales	Anaerobic Uptake	Sensitive	3	[NiFe]-centre, 3 x [4Fe4S] clusters	Cytochrome
WP_013163129.1	Desulfurivibrio alkaliphilus	[NiFe] Group 1b	Epsilonproteobacteria	Desulfobacterales	Anaerobic Uptake	Sensitive	3	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome
WP_013163642.1	Desulfurivibrio alkaliphilus	[NiFe] Group 3d	Deltaproteobacteria	Desulfobacterales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_022847517.1	Desulfurobacterium sp. TC5-1	[FeFe] Group A3	Aquificae	Desulfurobacteriales	Bifurcating	Labile	3	[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster	NADH dehydrogenase, thioredoxin
WP_022846122.1	Desulfurobacterium sp. TC5-1	[NiFe] Group 1c	Aquificae	Desulfurobacteriales	Anaerobic Uptake	Sensitive	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	[FeS] protein, TM subunit
WP_022846160.1	Desulfurobacterium sp. TC5-1	[NiFe] Group 3a	Aquificae	Desulfurobacteriales	Anaerobic Uptake	Sensitive	3	[NiFe]-centre, 3 x [4Fe4S] clusters	F420 reductase
WP_013637757.1	Desulfurobacterium thermolithotrophum	[FeFe] Group A3	Aquificae	Desulfurobacteriales	Bifurcating	Labile	3	[FeFe]-centre, 2 x [4Fe4S] clusters	NADH dehydrogenase, thioredoxin
WP_013638066.1	Desulfurobacterium thermolithotrophum	[NiFe] Group 1c	Aquificae	Desulfurobacteriales	Anaerobic Uptake	Sensitive	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	[FeS] protein, TM subunit
WP_013638061.1	Desulfurobacterium thermolithotrophum	[NiFe] Group 3a	Aquificae	Desulfurobacteriales	Anaerobic Uptake	Sensitive	3	[NiFe]-centre, 3 x [4Fe4S] clusters	F420 reductase
WP_013638346.1	Desulfurobacterium thermolithotrophum	[NiFe] Group 3b	Aquificae	Desulfurobacteriales	Bidirectional	Tolerant	4	[NiFe]-centre, 3 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_013637988.1	Desulfurobacterium thermolithotrophum	[NiFe] Group 3c	Aquificae	Desulfurobacteriales	Bifurcating	Sensitive	4	[NiFe]-centre, 3 x [4Fe4S] clusters	Polyferredoxin, [FeS] protein
WP_013638341.1	Desulfurobacterium thermolithotrophum	[NiFe] Group 4e	Aquificae	Desulfurobacteriales	Evolving	Sensitive	6	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, [FeS] protein
WP_014767907.1	Desulfurococcus fermentans	[NiFe] Group 4b	Crenarchaeota	Desulfurococcales	Evolving	Sensitive	13	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, two [FeS] proteins, seven MRP antiporter subunits, etc.
WP_012608688.1	Desulfurococcus kamchatkensis	[NiFe] Group 4b	Crenarchaeota	Desulfurococcales	Evolving	Sensitive	13	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, two [FeS] proteins, seven MRP antiporter subunits, etc.
WP_013561596.1	Desulfurococcus mucosus	[NiFe] Group 4b	Crenarchaeota	Desulfurococcales	Evolving	Sensitive	13	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, two [FeS] proteins, seven MRP antiporter subunits, etc.
WP_006002638.1	Desulfuromonas acetoxidans	[FeFe] Group C3	Deltaproteobacteria	Desulfovibrionales	Sensory	Labile	1	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Fusion with transcriptional activator
WP_027713781.1	Desulfuromonas sp. TF	[NiFe] Group 1f	Deltaproteobacteria	Desulfuromonadales	Anaerobic Uptake	Unknown	3	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	Cytochrome b
WP_027716793.1	Desulfuromonas sp. TF	[NiFe] Group 3b	Deltaproteobacteria	Desulfuromonadales	Bidirectional	Tolerant	4	[NiFe]-centre, 3 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_027716617.1	Desulfuromonas sp. TF	[NiFe] Group 4e	Deltaproteobacteria	Desulfuromonadales	Evolving	Sensitive	6	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, [FeS] protein
WP_008515176.1	Dethiobacter alkaliphilus	[NiFe] Group 3b	Firmicutes	Clostridiales	Bidirectional	Tolerant	4	[NiFe]-centre, 3 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_005659983.1	Dethiosulfovibrio peptidovorans	[FeFe] Group C3	Synergistetes	Synergistales	Sensory	Labile	3	[FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain	Phosphatase, thioredoxin
WP_005661842.1	Dethiosulfovibrio peptidovorans	[NiFe] Group 3d	Synergistetes	Synergistales	Bidirectional	Tolerant	4	[NiFe]-centre, 1 x [4Fe4S] clusters	Diaphorase, [FeS] protein
WP_005662523.1	Dethiosulfovibrio peptidovorans	[NiFe] Group 4d	Synergistetes	Synergistales	Evolving	Sensitive	13	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, two [FeS] proteins, seven MRP antiporter subunits, etc.
WP_007070913.1	Dialister invisus	[NiFe] Group 4e	Firmicutes	Selenomonadales	Evolving	Sensitive	6	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, [FeS] protein
WP_022106764.1	Dialister sp. CAG:486	[NiFe] Group 4e	Firmicutes	Selenomonadales	Evolving	Sensitive	6	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, [FeS] protein
WP_008860581.1	Dialister succinatiphilus	[NiFe] Group 4e	Firmicutes	Selenomonadales	Evolving	Sensitive	6	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, NuoC, [FeS] protein
WP_013318689.1	Dickeya dadantii	[NiFe] Group 1c	Gammaproteobacteria	Enterobacteriales	Anaerobic Uptake	Sensitive	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	[FeS] protein, TM subunit
WP_013317233.1	Dickeya dadantii	[NiFe] Group 4a	Gammaproteobacteria	Enterobacteriales	Evolving	Sensitive	6 or 9	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, two [FeS] proteins, (three antiporter subunits)
WP_024106579.1	Dickeya dianthicola	[NiFe] Group 1c	Gammaproteobacteria	Enterobacteriales	Anaerobic Uptake	Sensitive	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	[FeS] protein, TM subunit
WP_024105256.1	Dickeya dianthicola	[NiFe] Group 4a	Gammaproteobacteria	Enterobacteriales	Evolving	Sensitive	6 or 9	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, two [FeS] proteins, (three antiporter subunits)
WP_022634172.1	Dickeya solani	[NiFe] Group 1c	Gammaproteobacteria	Enterobacteriales	Anaerobic Uptake	Sensitive	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	[FeS] protein, TM subunit
WP_022632933.1	Dickeya solani	[NiFe] Group 4a	Gammaproteobacteria	Enterobacteriales	Evolving	Sensitive	6 or 9	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, two [FeS] proteins, (three antiporter subunits)
WP_016941064.1	Dickeya zeae	[NiFe] Group 1c	Gammaproteobacteria	Enterobacteriales	Anaerobic Uptake	Sensitive	4	[NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster	[FeS] protein, TM subunit
WP_019844844.1	Dickeya zeae	[NiFe] Group 4a	Gammaproteobacteria	Enterobacteriales	Evolving	Sensitive	6 or 9	[NiFe]-centre, 1 x [4Fe4S] clusters	NuoL, NuoH, two [FeS] proteins, (three antiporter subunits)

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