This entry was last updated at: June 13, 2016, 11:11 a.m.
Group | [NiFe] Group 4: Respiratory H2-evolving [NiFe] hydrogenases |
Subgroup | [NiFe] Group 4e: Ferredoxin-coupled, Ech-type |
Function | Forms respiratory complex that couples oxidation of ferredoxinred to reduction of protons to H2 in acetoclastic methanogenesis. This process appears to be coupled to sodium or proton translocation through the transmembrane modules. The complex can also act in the reverse direction during hydrogenotrophic methanogenesis. |
Activity | Bidirectional |
Oxygen tolerance | O2-sensitive |
Localisation | Membrane-bound |
Ecosystem distribution | Anoxic soils and sediments, animal gastrointestinal tracts |
Taxonomic distribution | Encoded in multiple methanogenic orders and anaerobic bacteria |
e.g. Methanosarcina barkeri (WP_011305188.1):
Structures |
|
Subunits | 6 |
Subunit description | EchA (hydrogenase large subunit) EchC (hydrogenase small subunit) EchF (iron-sulfur subunit) EchB (NuoH-like transmembrane adaptor) EchA (NuoL-like transmembrane adaptor) EchD (NuoC-like transmembrane adaptor) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: Absent Distal: Absent |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_012995592.1 | Thermoanaerobacter italicus | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_006569905.1 | Thermoanaerobacter siderophilus | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_029688128.1 | Thermoanaerobacter sp. A7A | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_004399987.1 | Thermoanaerobacter thermohydrosulfuricus | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_014062054.1 | Thermoanaerobacter wiegelii | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_014757614.1 | Thermoanaerobacterium saccharolyticum | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013296689.1 | Thermoanaerobacterium thermosaccharolyticum | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013786935.1 | Thermoanaerobacterium xylanolyticum | [NiFe] Group 4e | Firmicutes | Thermoanaerobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012035507.1 | Methanocella arvoryzae | [NiFe] Group 4e | Euryarchaeota | Methanocellales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_014405402.1 | Methanocella conradii | [NiFe] Group 4e | Euryarchaeota | Methanocellales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012899275.1 | Methanocella paludicola | [NiFe] Group 4e | Euryarchaeota | Methanocellales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012899230.1 | Methanocella paludicola | [NiFe] Group 4e | Euryarchaeota | Methanocellales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_014867437.1 | Methanoculleus bourgensis | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_011843203.1 | Methanoculleus marisnigri | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_004039320.1 | Methanofollis liminatans | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_020449518.1 | Methanomassiliicoccus intestinalis | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_019176382.1 | Methanomassiliicoccus luminyensis | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_004077817.1 | Methanoplanus limicola | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013328417.1 | Methanoplanus petrolearius | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_011991040.1 | Methanoregula boonei | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015284201.1 | Methanoregula formicica | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012619310.1 | Methanosphaerula palustris | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_011448732.1 | Methanospirillum hungatei | [NiFe] Group 4e | Euryarchaeota | Methanomicrobiales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_011305188.1 | Methanosarcina barkeri | [NiFe] Group 4e | Euryarchaeota | Methanosarcinales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_011034248.1 | Methanosarcina mazei | [NiFe] Group 4e | Euryarchaeota | Methanosarcinales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013460916.1 | Sulfuricurvum kujiense | [NiFe] Group 4e | Epsilonproteobacteria | Campylobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015654365.1 | Sulfuricurvum sp. RIFRC-1 | [NiFe] Group 4e | Epsilonproteobacteria | Campylobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_008340210.1 | Sulfurimonas gotlandica | [NiFe] Group 4e | Epsilonproteobacteria | Campylobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_007474009.1 | Caminibacter mediatlanticus | [NiFe] Group 4e | Epsilonproteobacteria | Nautiliales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_024789181.1 | Lebetimonas sp. JH292 | [NiFe] Group 4e | Epsilonproteobacteria | Nautiliales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012663581.1 | Nautilia profundicola | [NiFe] Group 4e | Epsilonproteobacteria | Nautiliales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_020585229.1 | Desulfobacter curvatus | [NiFe] Group 4e | Deltaproteobacteria | Desulfobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_021758533.1 | Desulfovibrio gigas | [NiFe] Group 4e | Deltaproteobacteria | Desulfobacterales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_028587759.1 | Desulfocurvus vexinensis | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_028576381.1 | Desulfomicrobium escambiense | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_028573897.1 | Desulfonatronovibrio hydrogenovorans | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_028572004.1 | Desulfonatronum lacustre | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_029967123.1 | Desulfonauticus sp. A7A | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_013515288.1 | Desulfovibrio aespoeensis | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_005986921.1 | Desulfovibrio africanus | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_020887613.1 | Desulfovibrio alkalitolerans | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027178908.1 | Desulfovibrio bastinii | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027187946.1 | Desulfovibrio cuneatus | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012625292.1 | Desulfovibrio desulfuricans | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_014323623.1 | Desulfovibrio desulfuricans | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_015336113.1 | Desulfovibrio hydrothermalis | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_027182881.1 | Desulfovibrio inopinatus | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_022661459.1 | Desulfovibrio longus | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_012749853.1 | Desulfovibrio magneticus | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
WP_018125731.1 | Desulfovibrio oxyclinae | [NiFe] Group 4e | Deltaproteobacteria | Desulfovibrionales | Evolving | Sensitive | 6 | [NiFe]-centre, 1 x [4Fe4S] clusters | NuoL, NuoH, NuoC, [FeS] protein |
Genetics:
Physiology:
Biochemistry: