This entry was last updated at: Feb. 9, 2018, 6:37 a.m.
Group | [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases |
Subgroup | [NiFe] Group 3d: NAD-coupled |
Function | Generates reductant for hydrogenotrophic carbon-fixation by directly coupling oxidation of H2 to reduction of NAD. Also acts in reverse direction to catalyse fermentative NADH-dependent production of H2. Electrons flow between H2-activating hydrogenase subunits to NAD-activating diaphorase subunits. |
Activity | Bidirectional |
Oxygen tolerance | O2-tolerant |
Localisation | Cytosolic |
Ecosystem distribution | Diverse soil and aquatic environments |
Taxonomic distribution | Encoded in diverse Proteobacteria and Cyanobacteria |
e.g. Ralstonia eutropha (WP_011154013.1):
Structures | |
Subunits | 4 or 5 |
Subunit description | HoxH (hydrogenase large subunit) HoxY (hydrogenase small subunit) HoxF (diaphorase catalytic subunit) HoxU (diaphorase electron transfer subunit) Photosynthetic bacteria also contain HoxE (iron-sulfur subunit) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: Absent Distal: Absent |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_026596337.1 | Methylohalobius crimeensis | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_005370476.1 | Methylomicrobium album | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014147789.1 | Methylomicrobium alcaliphilum | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_017839865.1 | Methylomicrobium buryatense | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013816969.1 | Methylomonas methanica | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_026601561.1 | Methylomonas sp. 11b | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020482704.1 | Methylomonas sp. MK1 | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020565381.1 | Methylosarcina fibrata | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_024299641.1 | Methylosarcina lacus | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018412521.1 | Methyloversatilis sp. NVD | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020162845.1 | Methyloversatilis universalis | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_019865758.1 | Methylovulum miyakonense | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015182972.1 | Microcoleus sp. PCC 7113 | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_016514321.1 | Microcystis aeruginosa | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008203468.1 | Microcystis sp. T1-4 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014208491.1 | Mycobacterium rhodesiae | [NiFe] Group 3d | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011781268.1 | Mycobacterium vanbaalenii | [NiFe] Group 3d | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013966114.1 | Nitrosomonas sp. Is79A3 | [NiFe] Group 3d | Betaproteobacteria | Nitrosomonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011380994.1 | Nitrosospira multiformis | [NiFe] Group 3d | Betaproteobacteria | Nitrosomonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004174406.1 | Nitrosospira sp. APG3 | [NiFe] Group 3d | Betaproteobacteria | Nitrosomonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006195766.1 | Nodularia spumigena | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015113185.1 | Nostoc sp. PCC 7107 | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_010994940.1 | Nostoc sp. PCC 7120 | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015138057.1 | Nostoc sp. PCC 7524 | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015151979.1 | Oscillatoria acuminata | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015175286.1 | Oscillatoria nigro-viridis | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_017715405.1 | Oscillatoria sp. PCC 10802 | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006562473.1 | Oscillochloris trichoides | [NiFe] Group 3d | Chloroflexi | Chloroflexales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015144267.1 | Pleurocapsa minor | [NiFe] Group 3d | Cyanobacteria | Pleurocapsales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_019509061.1 | Pleurocapsa sp. PCC 7319 | [NiFe] Group 3d | Cyanobacteria | Pleurocapsales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_019498425.1 | Pseudanabaena sp. PCC 6802 | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028864775.1 | Psychromonas aquimarina | [NiFe] Group 3d | Gammaproteobacteria | Alteromonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011769610.1 | Psychromonas ingrahamii | [NiFe] Group 3d | Gammaproteobacteria | Alteromonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011154013.1 | Ralstonia eutropha | [NiFe] Group 3d | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009341606.1 | Raphidiopsis brookii | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011466117.1 | Rhodoferax ferrireducens | [NiFe] Group 3d | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008384205.1 | Rhodovulum sp. PH10 | [NiFe] Group 3d | Alphaproteobacteria | Rhodobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012119893.1 | Roseiflexus castenholzii | [NiFe] Group 3d | Chloroflexi | Chloroflexales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011958239.1 | Roseiflexus sp. RS-1 | [NiFe] Group 3d | Chloroflexi | Chloroflexales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_029133296.1 | Sedimenticola selenatireducens | [NiFe] Group 3d | Gammaproteobacteria | Unclassified | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_023490135.1 | Serratia sp. DD3 | [NiFe] Group 3d | Gammaproteobacteria | Enterobacteriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013029742.1 | Sideroxydans lithotrophicus | [NiFe] Group 3d | Betaproteobacteria | Gallionellales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011686721.1 | Solibacter usitatus | [NiFe] Group 3d | Acidobacteria | Solibacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_017305034.1 | Spirulina subsalsa | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009205622.1 | Sulfuricella denitrificans | [NiFe] Group 3d | Betaproteobacteria | Hydrogenophilales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_021287226.1 | Sulfurimonas sp. AST-10 | [NiFe] Group 3d | Epsilonproteobacteria | Campylobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_022771893.1 | Symbiobacter mobilis | [NiFe] Group 3d | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011378516.1 | Synechococcus elongatus | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_029552892.1 | Synechococcus sp. CB0101 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_024545803.1 | Synechococcus sp. NKBG15041c | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
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