This entry was last updated at: Feb. 9, 2018, 6:37 a.m.
Group | [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases |
Subgroup | [NiFe] Group 3d: NAD-coupled |
Function | Generates reductant for hydrogenotrophic carbon-fixation by directly coupling oxidation of H2 to reduction of NAD. Also acts in reverse direction to catalyse fermentative NADH-dependent production of H2. Electrons flow between H2-activating hydrogenase subunits to NAD-activating diaphorase subunits. |
Activity | Bidirectional |
Oxygen tolerance | O2-tolerant |
Localisation | Cytosolic |
Ecosystem distribution | Diverse soil and aquatic environments |
Taxonomic distribution | Encoded in diverse Proteobacteria and Cyanobacteria |
e.g. Ralstonia eutropha (WP_011154013.1):
Structures | |
Subunits | 4 or 5 |
Subunit description | HoxH (hydrogenase large subunit) HoxY (hydrogenase small subunit) HoxF (diaphorase catalytic subunit) HoxU (diaphorase electron transfer subunit) Photosynthetic bacteria also contain HoxE (iron-sulfur subunit) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: Absent Distal: Absent |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_012470833.1 | Geobacter lovleyi | [NiFe] Group 3d | Deltaproteobacteria | Desulfuromonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_017294725.1 | Geminocystis herdmanii | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015171978.1 | Geitlerinema sp. PCC 7407 | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_017659307.1 | Geitlerinema sp. PCC 7105 | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013293541.1 | Gallionella capsiferriformans | [NiFe] Group 3d | Betaproteobacteria | Gallionellales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_016872130.1 | Fischerella thermalis | [NiFe] Group 3d | Cyanobacteria | Stigonematales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_026735631.1 | Fischerella sp. PCC 9605 | [NiFe] Group 3d | Cyanobacteria | Stigonematales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009756785.1 | Fischerella sp. JSC-11 | [NiFe] Group 3d | Cyanobacteria | Stigonematales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_016860165.1 | Fischerella muscicola | [NiFe] Group 3d | Cyanobacteria | Stigonematales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028085013.1 | Dolichospermum circinale | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028088931.1 | Dolichospermum circinale | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012582502.1 | Dictyoglomus turgidum | [NiFe] Group 3d | Dictyoglomi | Dictyoglomales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012548375.1 | Dictyoglomus thermophilum | [NiFe] Group 3d | Dictyoglomi | Dictyoglomales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_005661842.1 | Dethiosulfovibrio peptidovorans | [NiFe] Group 3d | Synergistetes | Synergistales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013163642.1 | Desulfurivibrio alkaliphilus | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013506608.1 | Desulfurispirillum indicum | [NiFe] Group 3d | Chrysiogenetes | Chrysiogenales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011189453.1 | Desulfotalea psychrophila | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014808238.1 | Desulfomonile tiedjei | [NiFe] Group 3d | Deltaproteobacteria | Syntrophobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020876264.1 | Desulfococcus multivorans | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015724758.1 | Desulfobulbus propionicus | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028585846.1 | Desulfobulbus mediterraneus | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028582678.1 | Desulfobulbus japonicus | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028317309.1 | Desulfobulbus elongatus | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_027457859.1 | Dechloromonas agitata | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006276675.1 | Cylindrospermopsis raciborskii | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020932782.1 | Cycloclasticus zancles | [NiFe] Group 3d | Gammaproteobacteria | Thiotrichales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_016389591.1 | Cycloclasticus sp. PY97M | [NiFe] Group 3d | Gammaproteobacteria | Thiotrichales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015005599.1 | Cycloclasticus sp. P1 | [NiFe] Group 3d | Gammaproteobacteria | Thiotrichales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020161995.1 | Cycloclasticus pugetii | [NiFe] Group 3d | Gammaproteobacteria | Thiotrichales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012593478.1 | Cyanothece sp. PCC 8801 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013323481.1 | Cyanothece sp. PCC 7822 | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012629409.1 | Cyanothece sp. PCC 7425 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015956115.1 | Cyanothece sp. PCC 7424 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008273694.1 | Cyanothece sp. CCY0110 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006910395.1 | Cyanobium sp. PCC 7001 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015110900.1 | Cyanobium gracile | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015221229.1 | Cyanobacterium aponinum | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011516268.1 | Cupriavidus metallidurans | [NiFe] Group 3d | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006101686.1 | Coleofasciculus chthonoplastes | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_027388897.1 | Chrysiogenes arsenatis | [NiFe] Group 3d | Chrysiogenetes | Chrysiogenales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015153897.1 | Chroococcidiopsis thermalis | [NiFe] Group 3d | Cyanobacteria | Pleurocapsales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_016874926.1 | Chlorogloeopsis fritschii | [NiFe] Group 3d | Cyanobacteria | Stigonematales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028457902.1 | Chloroflexus sp. Y-396-1 | [NiFe] Group 3d | Chloroflexi | Chloroflexales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015941206.1 | Chloroflexus aggregans | [NiFe] Group 3d | Chloroflexi | Chloroflexales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028455450.1 | Chitinilyticum litopenaei | [NiFe] Group 3d | Betaproteobacteria | Neisseriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028451929.1 | Chitinilyticum aquatile | [NiFe] Group 3d | Betaproteobacteria | Neisseriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013451671.1 | Calditerrivibrio nitroreducens | [NiFe] Group 3d | Deferribacteres | Deferribacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014434113.1 | Caldilinea aerophila | [NiFe] Group 3d | Chloroflexi | Caldilineales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011493687.1 | Burkholderia xenovorans | [NiFe] Group 3d | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_026687097.1 | Azovibrio restrictus | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
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