This entry was last updated at: Feb. 9, 2018, 6:37 a.m.
Group | [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases |
Subgroup | [NiFe] Group 3d: NAD-coupled |
Function | Generates reductant for hydrogenotrophic carbon-fixation by directly coupling oxidation of H2 to reduction of NAD. Also acts in reverse direction to catalyse fermentative NADH-dependent production of H2. Electrons flow between H2-activating hydrogenase subunits to NAD-activating diaphorase subunits. |
Activity | Bidirectional |
Oxygen tolerance | O2-tolerant |
Localisation | Cytosolic |
Ecosystem distribution | Diverse soil and aquatic environments |
Taxonomic distribution | Encoded in diverse Proteobacteria and Cyanobacteria |
e.g. Ralstonia eutropha (WP_011154013.1):
Structures | |
Subunits | 4 or 5 |
Subunit description | HoxH (hydrogenase large subunit) HoxY (hydrogenase small subunit) HoxF (diaphorase catalytic subunit) HoxU (diaphorase electron transfer subunit) Photosynthetic bacteria also contain HoxE (iron-sulfur subunit) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: Absent Distal: Absent |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_014238042.1 | Azospira oryzae | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028994701.1 | Azonexus hydrophilus | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018992236.1 | Azoarcus toluclasticus | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015436644.1 | Azoarcus sp. KH32C | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011765148.1 | Azoarcus sp. BH72 | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008053057.1 | Arthrospira sp. PCC 8005 | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006624081.1 | Arthrospira platensis | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006669190.1 | Arthrospira maxima | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_027404530.1 | Aphanizomenon flos-aquae | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013559391.1 | Anaerolinea thermophila | [NiFe] Group 3d | Chloroflexi | Anaerolineales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013559677.1 | Anaerolinea thermophila | [NiFe] Group 3d | Chloroflexi | Anaerolineales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014807493.1 | Anaerobaculum mobile | [NiFe] Group 3d | Synergistetes | Synergistales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009200281.1 | Anaerobaculum hydrogeniformans | [NiFe] Group 3d | Synergistetes | Synergistales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011321324.1 | Anabaena variabilis | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_016952407.1 | Anabaena sp. PCC 7108 | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015079811.1 | Anabaena sp. 90 | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015216232.1 | Anabaena cylindrica | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_024821667.1 | Aminobacterium mobile | [NiFe] Group 3d | Synergistetes | Synergistales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013048933.1 | Aminobacterium colombiense | [NiFe] Group 3d | Synergistetes | Synergistales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_029165455.1 | Aminiphilus circumscriptus | [NiFe] Group 3d | Synergistetes | Synergistales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012971066.1 | Allochromatium vinosum | [NiFe] Group 3d | Gammaproteobacteria | Chromatiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015765571.1 | Accumulibacter phosphatis | [NiFe] Group 3d | Betaproteobacteria | Unclassified | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_010476561.1 | Acaryochloris sp. CCMEE 5410 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012167698.1 | Acaryochloris marina | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
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