This entry was last updated at: Feb. 9, 2018, 6:37 a.m.
Group | [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases |
Subgroup | [NiFe] Group 3d: NAD-coupled |
Function | Generates reductant for hydrogenotrophic carbon-fixation by directly coupling oxidation of H2 to reduction of NAD. Also acts in reverse direction to catalyse fermentative NADH-dependent production of H2. Electrons flow between H2-activating hydrogenase subunits to NAD-activating diaphorase subunits. |
Activity | Bidirectional |
Oxygen tolerance | O2-tolerant |
Localisation | Cytosolic |
Ecosystem distribution | Diverse soil and aquatic environments |
Taxonomic distribution | Encoded in diverse Proteobacteria and Cyanobacteria |
e.g. Ralstonia eutropha (WP_011154013.1):
Structures | |
Subunits | 4 or 5 |
Subunit description | HoxH (hydrogenase large subunit) HoxY (hydrogenase small subunit) HoxF (diaphorase catalytic subunit) HoxU (diaphorase electron transfer subunit) Photosynthetic bacteria also contain HoxE (iron-sulfur subunit) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: Absent Distal: Absent |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_006170040.1 | Synechococcus sp. WH 5701 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028947433.1 | Synechocystis sp. PCC 6714 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_010872716.1 | Synechocystis sp. PCC 6803 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_027388897.1 | Chrysiogenes arsenatis | [NiFe] Group 3d | Chrysiogenetes | Chrysiogenales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013506608.1 | Desulfurispirillum indicum | [NiFe] Group 3d | Chrysiogenetes | Chrysiogenales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013451671.1 | Calditerrivibrio nitroreducens | [NiFe] Group 3d | Deferribacteres | Deferribacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028317309.1 | Desulfobulbus elongatus | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028582678.1 | Desulfobulbus japonicus | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028585846.1 | Desulfobulbus mediterraneus | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015724758.1 | Desulfobulbus propionicus | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020876264.1 | Desulfococcus multivorans | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011189453.1 | Desulfotalea psychrophila | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013163642.1 | Desulfurivibrio alkaliphilus | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012470833.1 | Geobacter lovleyi | [NiFe] Group 3d | Deltaproteobacteria | Desulfuromonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004513769.1 | Geobacter metallireducens | [NiFe] Group 3d | Deltaproteobacteria | Desulfuromonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014551946.1 | Geobacter sulfurreducens | [NiFe] Group 3d | Deltaproteobacteria | Desulfuromonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012548375.1 | Dictyoglomus thermophilum | [NiFe] Group 3d | Dictyoglomi | Dictyoglomales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012582502.1 | Dictyoglomus turgidum | [NiFe] Group 3d | Dictyoglomi | Dictyoglomales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_023490135.1 | Serratia sp. DD3 | [NiFe] Group 3d | Gammaproteobacteria | Enterobacteriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013293541.1 | Gallionella capsiferriformans | [NiFe] Group 3d | Betaproteobacteria | Gallionellales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013029742.1 | Sideroxydans lithotrophicus | [NiFe] Group 3d | Betaproteobacteria | Gallionellales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008526412.1 | Halorhabdus tiamatea | [NiFe] Group 3d | Euryarchaeota | Halobacteriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015789840.1 | Halorhabdus utahensis | [NiFe] Group 3d | Euryarchaeota | Halobacteriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009205622.1 | Sulfuricella denitrificans | [NiFe] Group 3d | Betaproteobacteria | Hydrogenophilales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009849435.1 | Mariprofundus ferrooxydans | [NiFe] Group 3d | Zetaproteobacteria | Mariprofundales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_027159095.1 | Methylobacter luteus | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020158180.1 | Methylobacter marinus | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_027148209.1 | Methylobacter tundripaludum | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_010959484.1 | Methylococcus capsulatus | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_026596337.1 | Methylohalobius crimeensis | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_005370476.1 | Methylomicrobium album | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014147789.1 | Methylomicrobium alcaliphilum | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_017839865.1 | Methylomicrobium buryatense | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013816969.1 | Methylomonas methanica | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_026601561.1 | Methylomonas sp. 11b | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020482704.1 | Methylomonas sp. MK1 | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020565381.1 | Methylosarcina fibrata | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_024299641.1 | Methylosarcina lacus | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_019865758.1 | Methylovulum miyakonense | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028451929.1 | Chitinilyticum aquatile | [NiFe] Group 3d | Betaproteobacteria | Neisseriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028455450.1 | Chitinilyticum litopenaei | [NiFe] Group 3d | Betaproteobacteria | Neisseriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013966114.1 | Nitrosomonas sp. Is79A3 | [NiFe] Group 3d | Betaproteobacteria | Nitrosomonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011380994.1 | Nitrosospira multiformis | [NiFe] Group 3d | Betaproteobacteria | Nitrosomonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004174406.1 | Nitrosospira sp. APG3 | [NiFe] Group 3d | Betaproteobacteria | Nitrosomonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015216232.1 | Anabaena cylindrica | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015079811.1 | Anabaena sp. 90 | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_016952407.1 | Anabaena sp. PCC 7108 | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011321324.1 | Anabaena variabilis | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_027404530.1 | Aphanizomenon flos-aquae | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006276675.1 | Cylindrospermopsis raciborskii | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
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