This entry was last updated at: Feb. 9, 2018, 6:37 a.m.
Group | [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases |
Subgroup | [NiFe] Group 3d: NAD-coupled |
Function | Generates reductant for hydrogenotrophic carbon-fixation by directly coupling oxidation of H2 to reduction of NAD. Also acts in reverse direction to catalyse fermentative NADH-dependent production of H2. Electrons flow between H2-activating hydrogenase subunits to NAD-activating diaphorase subunits. |
Activity | Bidirectional |
Oxygen tolerance | O2-tolerant |
Localisation | Cytosolic |
Ecosystem distribution | Diverse soil and aquatic environments |
Taxonomic distribution | Encoded in diverse Proteobacteria and Cyanobacteria |
e.g. Ralstonia eutropha (WP_011154013.1):
Structures | |
Subunits | 4 or 5 |
Subunit description | HoxH (hydrogenase large subunit) HoxY (hydrogenase small subunit) HoxF (diaphorase catalytic subunit) HoxU (diaphorase electron transfer subunit) Photosynthetic bacteria also contain HoxE (iron-sulfur subunit) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: Absent Distal: Absent |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_011686721.1 | Solibacter usitatus | [NiFe] Group 3d | Acidobacteria | Solibacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014208491.1 | Mycobacterium rhodesiae | [NiFe] Group 3d | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011781268.1 | Mycobacterium vanbaalenii | [NiFe] Group 3d | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012591738.1 | Methylocella silvestris | [NiFe] Group 3d | Alphaproteobacteria | Rhizobiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020174963.1 | Methyloferula stellata | [NiFe] Group 3d | Alphaproteobacteria | Rhizobiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006931831.1 | Labrenzia aggregata | [NiFe] Group 3d | Alphaproteobacteria | Rhodobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008193041.1 | Labrenzia alexandrii | [NiFe] Group 3d | Alphaproteobacteria | Rhodobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008384205.1 | Rhodovulum sp. PH10 | [NiFe] Group 3d | Alphaproteobacteria | Rhodobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011385756.1 | Magnetospirillum magneticum | [NiFe] Group 3d | Alphaproteobacteria | Rhodospirillales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008616907.1 | Magnetospirillum sp. SO-1 | [NiFe] Group 3d | Alphaproteobacteria | Rhodospirillales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011493687.1 | Burkholderia xenovorans | [NiFe] Group 3d | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011516268.1 | Cupriavidus metallidurans | [NiFe] Group 3d | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012346489.1 | Leptothrix cholodnii | [NiFe] Group 3d | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011154013.1 | Ralstonia eutropha | [NiFe] Group 3d | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011466117.1 | Rhodoferax ferrireducens | [NiFe] Group 3d | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_022771893.1 | Symbiobacter mobilis | [NiFe] Group 3d | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013293541.1 | Gallionella capsiferriformans | [NiFe] Group 3d | Betaproteobacteria | Gallionellales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013029742.1 | Sideroxydans lithotrophicus | [NiFe] Group 3d | Betaproteobacteria | Gallionellales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009205622.1 | Sulfuricella denitrificans | [NiFe] Group 3d | Betaproteobacteria | Hydrogenophilales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028451929.1 | Chitinilyticum aquatile | [NiFe] Group 3d | Betaproteobacteria | Neisseriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028455450.1 | Chitinilyticum litopenaei | [NiFe] Group 3d | Betaproteobacteria | Neisseriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013966114.1 | Nitrosomonas sp. Is79A3 | [NiFe] Group 3d | Betaproteobacteria | Nitrosomonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011380994.1 | Nitrosospira multiformis | [NiFe] Group 3d | Betaproteobacteria | Nitrosomonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004174406.1 | Nitrosospira sp. APG3 | [NiFe] Group 3d | Betaproteobacteria | Nitrosomonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011765148.1 | Azoarcus sp. BH72 | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015436644.1 | Azoarcus sp. KH32C | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018992236.1 | Azoarcus toluclasticus | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028994701.1 | Azonexus hydrophilus | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014238042.1 | Azospira oryzae | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_026687097.1 | Azovibrio restrictus | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_027457859.1 | Dechloromonas agitata | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018412521.1 | Methyloversatilis sp. NVD | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020162845.1 | Methyloversatilis universalis | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004322153.1 | Thauera aminoaromatica | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004363405.1 | Thauera phenylacetica | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_002937457.1 | Thauera sp. 27 | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_002929027.1 | Thauera sp. 28 | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004252763.1 | Thauera sp. 63 | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012585448.1 | Thauera sp. MZ1T | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015765571.1 | Accumulibacter phosphatis | [NiFe] Group 3d | Betaproteobacteria | Unclassified | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013559391.1 | Anaerolinea thermophila | [NiFe] Group 3d | Chloroflexi | Anaerolineales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013559677.1 | Anaerolinea thermophila | [NiFe] Group 3d | Chloroflexi | Anaerolineales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014434113.1 | Caldilinea aerophila | [NiFe] Group 3d | Chloroflexi | Caldilineales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015941206.1 | Chloroflexus aggregans | [NiFe] Group 3d | Chloroflexi | Chloroflexales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028457902.1 | Chloroflexus sp. Y-396-1 | [NiFe] Group 3d | Chloroflexi | Chloroflexales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006562473.1 | Oscillochloris trichoides | [NiFe] Group 3d | Chloroflexi | Chloroflexales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012119893.1 | Roseiflexus castenholzii | [NiFe] Group 3d | Chloroflexi | Chloroflexales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011958239.1 | Roseiflexus sp. RS-1 | [NiFe] Group 3d | Chloroflexi | Chloroflexales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_027388897.1 | Chrysiogenes arsenatis | [NiFe] Group 3d | Chrysiogenetes | Chrysiogenales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013506608.1 | Desulfurispirillum indicum | [NiFe] Group 3d | Chrysiogenetes | Chrysiogenales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
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