This entry was last updated at: Feb. 9, 2018, 6:37 a.m.
Group | [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases |
Subgroup | [NiFe] Group 3d: NAD-coupled |
Function | Generates reductant for hydrogenotrophic carbon-fixation by directly coupling oxidation of H2 to reduction of NAD. Also acts in reverse direction to catalyse fermentative NADH-dependent production of H2. Electrons flow between H2-activating hydrogenase subunits to NAD-activating diaphorase subunits. |
Activity | Bidirectional |
Oxygen tolerance | O2-tolerant |
Localisation | Cytosolic |
Ecosystem distribution | Diverse soil and aquatic environments |
Taxonomic distribution | Encoded in diverse Proteobacteria and Cyanobacteria |
e.g. Ralstonia eutropha (WP_011154013.1):
Structures | |
Subunits | 4 or 5 |
Subunit description | HoxH (hydrogenase large subunit) HoxY (hydrogenase small subunit) HoxF (diaphorase catalytic subunit) HoxU (diaphorase electron transfer subunit) Photosynthetic bacteria also contain HoxE (iron-sulfur subunit) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: Absent Distal: Absent |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
AAP50523.1 | Thiocapsa roseopersicina | [NiFe] Group 3d | Gammaproteobacteria | Chromatiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
ADK12981.1 | Thiocapsa roseopersicina | [NiFe] Group 3d | Gammaproteobacteria | Chromatiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_002929027.1 | Thauera sp. 28 | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_002937457.1 | Thauera sp. 27 | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004174406.1 | Nitrosospira sp. APG3 | [NiFe] Group 3d | Betaproteobacteria | Nitrosomonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004252763.1 | Thauera sp. 63 | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004322153.1 | Thauera aminoaromatica | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004363405.1 | Thauera phenylacetica | [NiFe] Group 3d | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004513769.1 | Geobacter metallireducens | [NiFe] Group 3d | Deltaproteobacteria | Desulfuromonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_005370476.1 | Methylomicrobium album | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_005505390.1 | Grimontia hollisae | [NiFe] Group 3d | Gammaproteobacteria | Vibrionales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_005661842.1 | Dethiosulfovibrio peptidovorans | [NiFe] Group 3d | Synergistetes | Synergistales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006101686.1 | Coleofasciculus chthonoplastes | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006170040.1 | Synechococcus sp. WH 5701 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006195766.1 | Nodularia spumigena | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006276675.1 | Cylindrospermopsis raciborskii | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006512117.1 | Xenococcus sp. PCC 7305 | [NiFe] Group 3d | Cyanobacteria | Pleurocapsales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006512920.1 | Leptolyngbya sp. PCC 7375 | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006562473.1 | Oscillochloris trichoides | [NiFe] Group 3d | Chloroflexi | Chloroflexales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006624081.1 | Arthrospira platensis | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006669190.1 | Arthrospira maxima | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006910395.1 | Cyanobium sp. PCC 7001 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006931831.1 | Labrenzia aggregata | [NiFe] Group 3d | Alphaproteobacteria | Rhodobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_007042613.1 | Thiorhodococcus drewsii | [NiFe] Group 3d | Gammaproteobacteria | Chromatiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_007191642.1 | Thiocapsa marina | [NiFe] Group 3d | Gammaproteobacteria | Chromatiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_007191859.1 | Thiocapsa marina | [NiFe] Group 3d | Gammaproteobacteria | Chromatiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008053057.1 | Arthrospira sp. PCC 8005 | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008193041.1 | Labrenzia alexandrii | [NiFe] Group 3d | Alphaproteobacteria | Rhodobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008203468.1 | Microcystis sp. T1-4 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008273694.1 | Cyanothece sp. CCY0110 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008384205.1 | Rhodovulum sp. PH10 | [NiFe] Group 3d | Alphaproteobacteria | Rhodobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008526412.1 | Halorhabdus tiamatea | [NiFe] Group 3d | Euryarchaeota | Halobacteriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008616907.1 | Magnetospirillum sp. SO-1 | [NiFe] Group 3d | Alphaproteobacteria | Rhodospirillales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009150973.1 | Thiorhodovibrio sp. 970 | [NiFe] Group 3d | Gammaproteobacteria | Chromatiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009200281.1 | Anaerobaculum hydrogeniformans | [NiFe] Group 3d | Synergistetes | Synergistales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009205622.1 | Sulfuricella denitrificans | [NiFe] Group 3d | Betaproteobacteria | Hydrogenophilales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009341606.1 | Raphidiopsis brookii | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009756785.1 | Fischerella sp. JSC-11 | [NiFe] Group 3d | Cyanobacteria | Stigonematales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009785505.1 | Lyngbya sp. PCC 8106 | [NiFe] Group 3d | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_009849435.1 | Mariprofundus ferrooxydans | [NiFe] Group 3d | Zetaproteobacteria | Mariprofundales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_010476561.1 | Acaryochloris sp. CCMEE 5410 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_010872716.1 | Synechocystis sp. PCC 6803 | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_010959484.1 | Methylococcus capsulatus | [NiFe] Group 3d | Gammaproteobacteria | Methylococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_010994940.1 | Nostoc sp. PCC 7120 | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011154013.1 | Ralstonia eutropha | [NiFe] Group 3d | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011189453.1 | Desulfotalea psychrophila | [NiFe] Group 3d | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011321324.1 | Anabaena variabilis | [NiFe] Group 3d | Cyanobacteria | Nostocales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011378516.1 | Synechococcus elongatus | [NiFe] Group 3d | Cyanobacteria | Chroococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011380994.1 | Nitrosospira multiformis | [NiFe] Group 3d | Betaproteobacteria | Nitrosomonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011385756.1 | Magnetospirillum magneticum | [NiFe] Group 3d | Alphaproteobacteria | Rhodospirillales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 1 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
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