This entry was last updated at: June 13, 2016, 11:23 a.m.
Group | [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases |
Subgroup | [NiFe] Group 3c: Heterodisulfide reductase-linked |
Function | Bifurcates electrons from H2 to heterodisulfide and ferredoxin. This is the final step in the Wolfe cycle of methanogenesis. |
Activity | Electron-bifurcation |
Oxygen tolerance | O2-tolerant? |
Localisation | Cytosolic |
Ecosystem distribution | Methanogenic environments such as anoxic soils, marine sediments, and gastrointestinal tracts |
Taxonomic distribution | Encoded in most methanogens and sulfate-reducing bacteria |
e.g. Methanothermobacter marburgensis (WP_013296307.1):
Structures |
|
Subunits | 4 |
Subunit description | MvhA (hydrogenase large subunit) MvhG (hydrogenase small subunit) MvhD (iron-sulfur subunit) MvhB (polyferredoxin subunit) Forms complex with heterodisulfide reductase (HdrABC) |
Catalytic site | [NiFe]-centre or [NiFeSe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: 4Cys[4Fe4S] Distal: 4Cys[4Fe4S] |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_012376486.1 | Opitutus terrae | [NiFe] Group 3c | Verrucomicrobia | Opitutales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_022853555.1 | Thermodesulfatator atlanticus | [NiFe] Group 3c | Thermodesulfobacteria | Thermodesulfobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_028840908.1 | Thermodesulfobacterium hveragerdense | [NiFe] Group 3c | Thermodesulfobacteria | Thermodesulfobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_012545782.1 | Thermodesulfovibrio yellowstonii | [NiFe] Group 3c | Nitrospirae | Nitrospirales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
KKK40681.1 | Lokiarchaeum sp. GC14_75 | [NiFe] Group 3c | Lokiarchaeota | N/A | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_012309762.1 | Korarchaeum cryptofilum | [NiFe] Group 3c | Korarchaeota | Unclassified | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_012302733.1 | Desulforudis audaxviator | [NiFe] Group 3c | Firmicutes | Clostridiales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_015617925.1 | Desulfotomaculum gibsoniae | [NiFe] Group 3c | Firmicutes | Clostridiales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_015739967.1 | Ammonifex degensii | [NiFe] Group 3c | Firmicutes | Thermoanaerobacterales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_013756665.1 | Thermodesulfobium narugense | [NiFe] Group 3c | Firmicutes | Thermoanaerobacterales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_013908379.1 | Thermodesulfatator indicus | [NiFe] Group 3c | Firmicutes | Thermodesulfobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_010878869.1 | Archaeoglobus fulgidus | [NiFe] Group 3c | Euryarchaeota | Archaeoglobales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_015590675.1 | Archaeoglobus sulfaticallidus | [NiFe] Group 3c | Euryarchaeota | Archaeoglobales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_013684228.1 | Archaeoglobus veneficus | [NiFe] Group 3c | Euryarchaeota | Archaeoglobales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_012965352.1 | Ferroglobus placidus | [NiFe] Group 3c | Euryarchaeota | Archaeoglobales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_015233716.1 | Natronobacterium gregoryi | [NiFe] Group 3c | Euryarchaeota | Halobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_004032005.1 | Methanobacterium formicicum | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_004031311.1 | Methanobacterium formicicum | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_013644241.1 | Methanobacterium lacus | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_013643973.1 | Methanobacterium lacus | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_013826546.1 | Methanobacterium paludis | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_013826227.1 | Methanobacterium paludis | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_023992472.1 | Methanobacterium sp. MB1 | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_023992781.1 | Methanobacterium sp. MB1 | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_012956704.1 | Methanobrevibacter ruminantium | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_019264891.1 | Methanobrevibacter smithii | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_019262575.1 | Methanobrevibacter smithii | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_016359076.1 | Methanobrevibacter sp. AbM4 | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_011405926.1 | Methanosphaera stadtmanae | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_013296307.1 | Methanothermobacter marburgensis | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_010876758.1 | Methanothermobacter thermoautotrophicus | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_013413806.1 | Methanothermus fervidus | [NiFe] Group 3c | Euryarchaeota | Methanobacteriales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_012036601.1 | Methanocella arvoryzae | [NiFe] Group 3c | Euryarchaeota | Methanocellales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_012036509.1 | Methanocella arvoryzae | [NiFe] Group 3c | Euryarchaeota | Methanocellales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_014407035.1 | Methanocella conradii | [NiFe] Group 3c | Euryarchaeota | Methanocellales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_014404721.1 | Methanocella conradii | [NiFe] Group 3c | Euryarchaeota | Methanocellales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_012901238.1 | Methanocella paludicola | [NiFe] Group 3c | Euryarchaeota | Methanocellales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_012901516.1 | Methanocella paludicola | [NiFe] Group 3c | Euryarchaeota | Methanocellales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_015790819.1 | Methanocaldococcus fervens | [NiFe] Group 3c | Euryarchaeota | Methanococcales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_013099800.1 | Methanocaldococcus infernus | [NiFe] Group 3c | Euryarchaeota | Methanococcales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_010870705.1 | Methanocaldococcus jannaschii | [NiFe] Group 3c | Euryarchaeota | Methanococcales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_012980416.1 | Methanocaldococcus sp. FS406-22 | [NiFe] Group 3c | Euryarchaeota | Methanococcales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_012979819.1 | Methanocaldococcus sp. FS406-22 | [NiFe] Group 3c | Euryarchaeota | Methanococcales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_004589824.1 | Methanocaldococcus villosus | [NiFe] Group 3c | Euryarchaeota | Methanococcales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_015733560.1 | Methanocaldococcus vulcanius | [NiFe] Group 3c | Euryarchaeota | Methanococcales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_015732794.1 | Methanocaldococcus vulcanius | [NiFe] Group 3c | Euryarchaeota | Methanococcales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_011973924.1 | Methanococcus aeolicus | [NiFe] Group 3c | Euryarchaeota | Methanococcales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_011972821.1 | Methanococcus aeolicus | [NiFe] Group 3c | Euryarchaeota | Methanococcales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_011170767.1 | Methanococcus maripaludis | [NiFe] Group 3c | Euryarchaeota | Methanococcales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
WP_011171638.1 | Methanococcus maripaludis | [NiFe] Group 3c | Euryarchaeota | Methanococcales | Bifurcating | Sensitive | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Polyferredoxin, [FeS] protein |
Genetics:
Physiology:
Biochemistry:
Chemistry: