[NiFe] Group 3c-hydrogenase

This entry was last updated at: June 13, 2016, 11:23 a.m.

Properties
Group [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases
Subgroup [NiFe] Group 3c: Heterodisulfide reductase-linked
Function Bifurcates electrons from H2 to heterodisulfide and ferredoxin. This is the final step in the Wolfe cycle of methanogenesis.
Activity Electron-bifurcation
Oxygen tolerance O2-tolerant?
Localisation Cytosolic
Distribution
Ecosystem distribution Methanogenic environments such as anoxic soils, marine sediments, and gastrointestinal tracts
Taxonomic distribution Encoded in most methanogens and sulfate-reducing bacteria
Genetic Organisation

e.g. Methanothermobacter marburgensis (WP_013296307.1):

Architecture
Structures
    None
Subunits 4
Subunit description MvhA (hydrogenase large subunit)
MvhG (hydrogenase small subunit)
MvhD (iron-sulfur subunit)
MvhB (polyferredoxin subunit)
Forms complex with heterodisulfide reductase (HdrABC)
Catalytic site [NiFe]-centre or [NiFeSe]-centre
FeS clusters Proximal: 4Cys[4Fe4S]
Medial: 4Cys[4Fe4S]
Distal: 4Cys[4Fe4S]
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_029966039.1Desulfonauticus sp. A7A[NiFe] Group 3cDeltaproteobacteriaDesulfovibrionalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_029898901.1Desulfovibrio sp. L21-Syr-AB[NiFe] Group 3cDeltaproteobacteriaDesulfovibrionalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_028894885.1Syntrophorhabdus aromaticivorans[NiFe] Group 3cDeltaproteobacteriaSyntrophobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_028840908.1Thermodesulfobacterium hveragerdense[NiFe] Group 3cThermodesulfobacteriaThermodesulfobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_028584591.1Desulfobulbus mediterraneus[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_028583859.1Desulfobulbus mediterraneus[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_028580885.1Desulfobulbus japonicus[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_028580860.1Desulfobulbus japonicus[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_028574551.1Desulfonatronovibrio hydrogenovorans[NiFe] Group 3cDeltaproteobacteriaDesulfovibrionalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_028574115.1Desulfonatronovibrio hydrogenovorans[NiFe] Group 3cDeltaproteobacteriaDesulfovibrionalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_028318776.1Desulfobulbus elongatus[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_028317553.1Desulfobulbus elongatus[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_027371047.1Desulfovermiculus halophilus[NiFe] Group 3cDeltaproteobacteriaDesulfovibrionalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_027368703.1Desulfovibrio africanus[NiFe] Group 3cDeltaproteobacteriaDesulfovibrionalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_027358538.1Desulforegula conservatrix[NiFe] Group 3cDeltaproteobacteriaDesulfuromonadalesBidirectionalTolerant4[NiFe]-centre, 1 x [4Fe4S] clustersDiaphorase, [FeS] protein
WP_027191993.1Desulfovibrio putealis[NiFe] Group 3cDeltaproteobacteriaDesulfovibrionalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_027187949.1Desulfovibrio cuneatus[NiFe] Group 3cDeltaproteobacteriaDesulfovibrionalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_027183464.1Desulfovibrio inopinatus[NiFe] Group 3cDeltaproteobacteriaDesulfovibrionalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_026167551.1Desulfovibrio oxyclinae[NiFe] Group 3cDeltaproteobacteriaDesulfovibrionalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_023992781.1Methanobacterium sp. MB1[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_023992472.1Methanobacterium sp. MB1[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_023408290.1Desulfofustis sp. PB-SRB1[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_022853555.1Thermodesulfatator atlanticus[NiFe] Group 3cThermodesulfobacteriaThermodesulfobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_022775381.1Symbiobacter mobilis[NiFe] Group 3cBetaproteobacteriaBurkholderialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_022668938.1Desulfospira joergensenii[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_022532976.1Methanoculleus sp. CAG:1088[NiFe] Group 3cEuryarchaeotaMethanomicrobialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_020882283.1Desulfovibrio sp. X2[NiFe] Group 3cDeltaproteobacteriaDesulfovibrionalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_020448391.1Methanomassiliicoccus intestinalis[NiFe] Group 3cEuryarchaeotaMethanomicrobialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_019264891.1Methanobrevibacter smithii[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_019262575.1Methanobrevibacter smithii[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_019177457.1Methanomassiliicoccus luminyensis[NiFe] Group 3cEuryarchaeotaMethanomicrobialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_018154262.1Methanothermococcus thermolithotrophicus[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_018154225.1Methanothermococcus thermolithotrophicus[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_016359076.1Methanobrevibacter sp. AbM4[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015935331.1Anaeromyxobacter dehalogenans[NiFe] Group 3cDeltaproteobacteriaMyxococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015903075.1Desulfobacterium autotrophicum[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015839165.1Geobacter sp. M21[NiFe] Group 3cDeltaproteobacteriaDesulfuromonadalesBidirectionalTolerant4[NiFe]-centre, 1 x [4Fe4S] clustersDiaphorase, [FeS] protein
WP_015790819.1Methanocaldococcus fervens[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015752683.1Desulfohalobium retbaense[NiFe] Group 3cDeltaproteobacteriaDesulfovibrionalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015739967.1Ammonifex degensii[NiFe] Group 3cFirmicutesThermoanaerobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015733560.1Methanocaldococcus vulcanius[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015732794.1Methanocaldococcus vulcanius[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015724435.1Desulfobulbus propionicus[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015722755.1Desulfobulbus propionicus[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015617925.1Desulfotomaculum gibsoniae[NiFe] Group 3cFirmicutesClostridialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015590675.1Archaeoglobus sulfaticallidus[NiFe] Group 3cEuryarchaeotaArchaeoglobalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015504206.1Methanomethylophilus alvus[NiFe] Group 3cEuryarchaeotaUnclassifiedBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015233716.1Natronobacterium gregoryi[NiFe] Group 3cEuryarchaeotaHalobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_014867732.1Methanoculleus bourgensis[NiFe] Group 3cEuryarchaeotaMethanomicrobialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_014551809.1Geobacter sulfurreducens[NiFe] Group 3cDeltaproteobacteriaDesulfuromonadalesBidirectionalTolerant4[NiFe]-centre, 1 x [4Fe4S] clustersDiaphorase, [FeS] protein

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