[NiFe] Group 3c-hydrogenase

This entry was last updated at: June 13, 2016, 11:23 a.m.

Properties
Group [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases
Subgroup [NiFe] Group 3c: Heterodisulfide reductase-linked
Function Bifurcates electrons from H2 to heterodisulfide and ferredoxin. This is the final step in the Wolfe cycle of methanogenesis.
Activity Electron-bifurcation
Oxygen tolerance O2-tolerant?
Localisation Cytosolic
Distribution
Ecosystem distribution Methanogenic environments such as anoxic soils, marine sediments, and gastrointestinal tracts
Taxonomic distribution Encoded in most methanogens and sulfate-reducing bacteria
Genetic Organisation

e.g. Methanothermobacter marburgensis (WP_013296307.1):

Architecture
Structures
    None
Subunits 4
Subunit description MvhA (hydrogenase large subunit)
MvhG (hydrogenase small subunit)
MvhD (iron-sulfur subunit)
MvhB (polyferredoxin subunit)
Forms complex with heterodisulfide reductase (HdrABC)
Catalytic site [NiFe]-centre or [NiFeSe]-centre
FeS clusters Proximal: 4Cys[4Fe4S]
Medial: 4Cys[4Fe4S]
Distal: 4Cys[4Fe4S]
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_020448391.1Methanomassiliicoccus intestinalis[NiFe] Group 3cEuryarchaeotaMethanomicrobialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_019177457.1Methanomassiliicoccus luminyensis[NiFe] Group 3cEuryarchaeotaMethanomicrobialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013330634.1Methanoplanus petrolearius[NiFe] Group 3cEuryarchaeotaMethanomicrobialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_011018550.1Methanopyrus kandleri[NiFe] Group 3cEuryarchaeotaMethanopyralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_011018638.1Methanopyrus kandleri[NiFe] Group 3cEuryarchaeotaMethanopyralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015504206.1Methanomethylophilus alvus[NiFe] Group 3cEuryarchaeotaUnclassifiedBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012302733.1Desulforudis audaxviator[NiFe] Group 3cFirmicutesClostridialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015617925.1Desulfotomaculum gibsoniae[NiFe] Group 3cFirmicutesClostridialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015739967.1Ammonifex degensii[NiFe] Group 3cFirmicutesThermoanaerobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013756665.1Thermodesulfobium narugense[NiFe] Group 3cFirmicutesThermoanaerobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013908379.1Thermodesulfatator indicus[NiFe] Group 3cFirmicutesThermodesulfobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012309762.1Korarchaeum cryptofilum[NiFe] Group 3cKorarchaeotaUnclassifiedBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
KKK40681.1Lokiarchaeum sp. GC14_75[NiFe] Group 3cLokiarchaeotaN/ABifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012545782.1Thermodesulfovibrio yellowstonii[NiFe] Group 3cNitrospiraeNitrospiralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_022853555.1Thermodesulfatator atlanticus[NiFe] Group 3cThermodesulfobacteriaThermodesulfobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_028840908.1Thermodesulfobacterium hveragerdense[NiFe] Group 3cThermodesulfobacteriaThermodesulfobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012376486.1Opitutus terrae[NiFe] Group 3cVerrucomicrobiaOpitutalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein

Literature

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