[NiFe] Group 3c-hydrogenase

This entry was last updated at: June 13, 2016, 11:23 a.m.

Properties
Group [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases
Subgroup [NiFe] Group 3c: Heterodisulfide reductase-linked
Function Bifurcates electrons from H2 to heterodisulfide and ferredoxin. This is the final step in the Wolfe cycle of methanogenesis.
Activity Electron-bifurcation
Oxygen tolerance O2-tolerant?
Localisation Cytosolic
Distribution
Ecosystem distribution Methanogenic environments such as anoxic soils, marine sediments, and gastrointestinal tracts
Taxonomic distribution Encoded in most methanogens and sulfate-reducing bacteria
Genetic Organisation

e.g. Methanothermobacter marburgensis (WP_013296307.1):

Architecture
Structures
    None
Subunits 4
Subunit description MvhA (hydrogenase large subunit)
MvhG (hydrogenase small subunit)
MvhD (iron-sulfur subunit)
MvhB (polyferredoxin subunit)
Forms complex with heterodisulfide reductase (HdrABC)
Catalytic site [NiFe]-centre or [NiFeSe]-centre
FeS clusters Proximal: 4Cys[4Fe4S]
Medial: 4Cys[4Fe4S]
Distal: 4Cys[4Fe4S]
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_004032005.1Methanobacterium formicicum[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_004031311.1Methanobacterium formicicum[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013644241.1Methanobacterium lacus[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013643973.1Methanobacterium lacus[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013826546.1Methanobacterium paludis[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013826227.1Methanobacterium paludis[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_023992472.1Methanobacterium sp. MB1[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_023992781.1Methanobacterium sp. MB1[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012956704.1Methanobrevibacter ruminantium[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_019264891.1Methanobrevibacter smithii[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_019262575.1Methanobrevibacter smithii[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_016359076.1Methanobrevibacter sp. AbM4[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_011405926.1Methanosphaera stadtmanae[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013296307.1Methanothermobacter marburgensis[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_010876758.1Methanothermobacter thermoautotrophicus[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013413806.1Methanothermus fervidus[NiFe] Group 3cEuryarchaeotaMethanobacterialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012036601.1Methanocella arvoryzae[NiFe] Group 3cEuryarchaeotaMethanocellalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012036509.1Methanocella arvoryzae[NiFe] Group 3cEuryarchaeotaMethanocellalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_014407035.1Methanocella conradii[NiFe] Group 3cEuryarchaeotaMethanocellalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_014404721.1Methanocella conradii[NiFe] Group 3cEuryarchaeotaMethanocellalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012901238.1Methanocella paludicola[NiFe] Group 3cEuryarchaeotaMethanocellalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012901516.1Methanocella paludicola[NiFe] Group 3cEuryarchaeotaMethanocellalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015790819.1Methanocaldococcus fervens[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013099800.1Methanocaldococcus infernus[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_010870705.1Methanocaldococcus jannaschii[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012980416.1Methanocaldococcus sp. FS406-22[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012979819.1Methanocaldococcus sp. FS406-22[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_004589824.1Methanocaldococcus villosus[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015733560.1Methanocaldococcus vulcanius[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015732794.1Methanocaldococcus vulcanius[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_011973924.1Methanococcus aeolicus[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_011972821.1Methanococcus aeolicus[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_011170767.1Methanococcus maripaludis[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_011171638.1Methanococcus maripaludis[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012065828.1Methanococcus vannielii[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_011971888.1Methanococcus vannielii[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013180651.1Methanococcus voltae[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013179971.1Methanococcus voltae[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013866983.1Methanothermococcus okinawensis[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013866362.1 Methanothermococcus okinawensis[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_018154262.1Methanothermococcus thermolithotrophicus[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_018154225.1Methanothermococcus thermolithotrophicus[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_007044701.1Methanotorris formicicus[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_007043614.1Methanotorris formicicus[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013799074.1Methanotorris igneus[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013799334.1Methanotorris igneus[NiFe] Group 3cEuryarchaeotaMethanococcalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_014867732.1Methanoculleus bourgensis[NiFe] Group 3cEuryarchaeotaMethanomicrobialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_011843851.1Methanoculleus marisnigri[NiFe] Group 3cEuryarchaeotaMethanomicrobialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_022532976.1Methanoculleus sp. CAG:1088[NiFe] Group 3cEuryarchaeotaMethanomicrobialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_004039570.1Methanofollis liminatans[NiFe] Group 3cEuryarchaeotaMethanomicrobialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein

Literature

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