This entry was last updated at: Feb. 9, 2018, 7:34 a.m.
Group | [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases |
Subgroup | [NiFe] Group 3b: NADP-coupled |
Function | Directly couples oxidation of NADPH to fermentative evolution of H2. Reverse reaction may also occur. Some complexes controversially proposed to harbour sulfhydrogenase activity. |
Activity | Bidirectional |
Oxygen tolerance | O2-tolerant |
Localisation | Cytosolic |
Ecosystem distribution | Diverse soil and aquatic environments |
Taxonomic distribution | Encoded in multiple diverse bacterial and archaeal phyla |
e.g. Pyrococcus furiosus (WP_011012029.1):
Structures | |
Subunits | 4 |
Subunit description | HyhL (hydrogenase large subunit) HyhS (hydrogenase small subunit) HyhG (diaphorase catalytic subunit) HyhB (diaphorase electron transfer subunit) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: 4Cys[4Fe4S] Distal: 4Cys[4Fe4S] |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_027709971.1 | Zooshikella ganghwensis | [NiFe] Group 3b | Gammaproteobacteria | Oceanospirillales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018290138.1 | Verrucomicrobium sp. 3C | [NiFe] Group 3b | Verrucomicrobia | Verrucomicrobiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_024807859.1 | Verrucomicrobiae bacterium LP2A | [NiFe] Group 3b | Verrucomicrobia | Verrucomicrobiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_008098529.1 | Verrucomicrobiae bacterium DG1235 | [NiFe] Group 3b | Verrucomicrobia | Verrucomicrobiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018608874.1 | Uliginosibacterium gangwonense | [NiFe] Group 3b | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_002708355.1 | Thiothrix nivea | [NiFe] Group 3b | Gammaproteobacteria | Thiotrichales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028490240.1 | Thiothrix lacustris | [NiFe] Group 3b | Gammaproteobacteria | Thiotrichales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_006786889.1 | Thiorhodospira sibirica | [NiFe] Group 3b | Gammaproteobacteria | Chromatiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018508430.1 | Thiobacillus thioparus | [NiFe] Group 3b | Betaproteobacteria | Hydrogenophilales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011311775.1 | Thiobacillus denitrificans | [NiFe] Group 3b | Betaproteobacteria | Hydrogenophilales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012637708.1 | Thioalkalivibrio sulfidiphilus | [NiFe] Group 3b | Gammaproteobacteria | Chromatiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015258948.1 | Thioalkalivibrio nitratireducens | [NiFe] Group 3b | Gammaproteobacteria | Chromatiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013537242.1 | Thermovibrio ammonificans | [NiFe] Group 3b | Aquificae | Desulfurobacteriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014737726.1 | Thermogladius cellulolyticus | [NiFe] Group 3b | Crenarchaeota | Desulfurococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012544964.1 | Thermodesulfovibrio yellowstonii | [NiFe] Group 3b | Nitrospirae | Nitrospirales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028844226.1 | Thermodesulfovibrio thiophilus | [NiFe] Group 3b | Nitrospirae | Nitrospirales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028842337.1 | Thermodesulfovibrio islandicus | [NiFe] Group 3b | Nitrospirae | Nitrospirales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_010479591.1 | Thermococcus zilligii | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_010479608.1 | Thermococcus zilligii | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014788000.1 | Thermococcus sp. CL1 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014788486.1 | Thermococcus sp. CL1 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014122569.1 | Thermococcus sp. AM4 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014012081.1 | Thermococcus sp. 4557 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014012582.1 | Thermococcus sp. 4557 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015848571.1 | Thermococcus sibiricus | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015849791.1 | Thermococcus sibiricus | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012571493.1 | Thermococcus onnurineus | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012571009.1 | Thermococcus onnurineus | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020953630.1 | Thermococcus litoralis | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004069412.1 | Thermococcus litoralis | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011251019.1 | Thermococcus kodakarensis | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013466811.1 | Thermococcus barophilus | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013466346.1 | Thermococcus barophilus | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013132103.1 | Thermobispora bispora | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028989466.1 | Thermithiobacillus tepidarius | [NiFe] Group 3b | Gammaproteobacteria | Acidithiobacillales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015051716.1 | Thermacetogenium phaeum | [NiFe] Group 3b | Firmicutes | Thermoanaerobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_011416040.1 | Syntrophus aciditrophicus | [NiFe] Group 3b | Deltaproteobacteria | Syntrophobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_028949840.1 | Sulfurihydrogenibium subterraneum | [NiFe] Group 3b | Aquificae | Aquificales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012674555.1 | Sulfurihydrogenibium azorense | [NiFe] Group 3b | Aquificae | Aquificales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012891383.1 | Streptosporangium roseum | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018384886.1 | Streptomyces vitaminophilus | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_012998941.1 | Streptomyces scabiei | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_023544405.1 | Streptomyces roseochromogenes | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_003980535.1 | Streptomyces rimosus | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020874487.1 | Streptomyces rapamycinicus | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004946981.1 | Streptomyces mobaraensis | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014677317.1 | Streptomyces hygroscopicus | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_004936990.1 | Streptomyces griseoflavus | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015662841.1 | Streptomyces davawensis | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020123404.1 | Streptomyces canus | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
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