This entry was last updated at: Feb. 9, 2018, 7:34 a.m.
Group | [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases |
Subgroup | [NiFe] Group 3b: NADP-coupled |
Function | Directly couples oxidation of NADPH to fermentative evolution of H2. Reverse reaction may also occur. Some complexes controversially proposed to harbour sulfhydrogenase activity. |
Activity | Bidirectional |
Oxygen tolerance | O2-tolerant |
Localisation | Cytosolic |
Ecosystem distribution | Diverse soil and aquatic environments |
Taxonomic distribution | Encoded in multiple diverse bacterial and archaeal phyla |
e.g. Pyrococcus furiosus (WP_011012029.1):
Structures | |
Subunits | 4 |
Subunit description | HyhL (hydrogenase large subunit) HyhS (hydrogenase small subunit) HyhG (diaphorase catalytic subunit) HyhB (diaphorase electron transfer subunit) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: 4Cys[4Fe4S] Distal: 4Cys[4Fe4S] |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_013749130.1 | Pyrococcus sp. NA2 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013904776.1 | Pyrococcus yayanosii | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013905579.1 | Pyrococcus yayanosii | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013923702.1 | Francisella sp. TX077308 | [NiFe] Group 3b | Gammaproteobacteria | Thiotrichales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_013979629.1 | Eggerthella sp. YY7918 | [NiFe] Group 3b | Actinobacteria | Coriobacteriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014012081.1 | Thermococcus sp. 4557 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014012582.1 | Thermococcus sp. 4557 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014029204.1 | Acidithiobacillus ferrivorans | [NiFe] Group 3b | Gammaproteobacteria | Acidithiobacillales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014068049.1 | Rhodothermus marinus | [NiFe] Group 3b | Bacteroidetes | Unclassified | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014122569.1 | Thermococcus sp. AM4 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014292817.1 | Oceanimonas sp. GK1 | [NiFe] Group 3b | Gammaproteobacteria | Aeromonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014433201.1 | Caldilinea aerophila | [NiFe] Group 3b | Chloroflexi | Caldilineales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014558156.1 | Fervidicoccus fontis | [NiFe] Group 3b | Crenarchaeota | Fervidicoccales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014677317.1 | Streptomyces hygroscopicus | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014734005.1 | Pyrococcus sp. ST04 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014734228.1 | Pyrococcus sp. ST04 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014737726.1 | Thermogladius cellulolyticus | [NiFe] Group 3b | Crenarchaeota | Desulfurococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014788000.1 | Thermococcus sp. CL1 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014788486.1 | Thermococcus sp. CL1 | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014814971.1 | Mycobacterium chubuense | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_014890330.1 | Methylocystis sp. SC2 | [NiFe] Group 3b | Alphaproteobacteria | Rhizobiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015051716.1 | Thermacetogenium phaeum | [NiFe] Group 3b | Firmicutes | Thermoanaerobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015258948.1 | Thioalkalivibrio nitratireducens | [NiFe] Group 3b | Gammaproteobacteria | Chromatiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015283468.1 | Aciduliprofundum sp. MAR08-339 | [NiFe] Group 3b | Euryarchaeota | Unclassified | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015403594.1 | Desulfocapsa sulfexigens | [NiFe] Group 3b | Deltaproteobacteria | Desulfobacterales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015662841.1 | Streptomyces davawensis | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015720565.1 | Geobacter sp. M18 | [NiFe] Group 3b | Deltaproteobacteria | Desulfuromonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015760489.1 | Eggerthella lenta | [NiFe] Group 3b | Actinobacteria | Coriobacteriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015790329.1 | Halorhabdus utahensis | [NiFe] Group 3b | Euryarchaeota | Halobacteriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015837532.1 | Geobacter sp. M21 | [NiFe] Group 3b | Deltaproteobacteria | Desulfuromonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015848571.1 | Thermococcus sibiricus | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_015849791.1 | Thermococcus sibiricus | [NiFe] Group 3b | Euryarchaeota | Thermococcales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_016308610.1 | Enterorhabdus caecimuris | [NiFe] Group 3b | Actinobacteria | Coriobacteriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_016920195.1 | Methylocystis parvus | [NiFe] Group 3b | Alphaproteobacteria | Rhizobiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_017290644.1 | Leptolyngbya boryana | [NiFe] Group 3b | Cyanobacteria | Oscillatoriales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_017774733.1 | Burkholderia kururiensis | [NiFe] Group 3b | Betaproteobacteria | Burkholderiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_017873497.1 | Caldatribacterium saccharofermentans | [NiFe] Group 3b | Atribacteria | Unclassified | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_017890430.1 | Caldatribacterium californiense | [NiFe] Group 3b | Atribacteria | Unclassified | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018160400.1 | Smaragdicoccus niigatensis | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018265836.1 | Methylosinus sp. LW4 | [NiFe] Group 3b | Alphaproteobacteria | Rhizobiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018290138.1 | Verrucomicrobium sp. 3C | [NiFe] Group 3b | Verrucomicrobia | Verrucomicrobiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018300187.1 | Fangia hongkongensis | [NiFe] Group 3b | Gammaproteobacteria | Thiotrichales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018384886.1 | Streptomyces vitaminophilus | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018407885.1 | Methylocystis rosea | [NiFe] Group 3b | Alphaproteobacteria | Rhizobiales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018508430.1 | Thiobacillus thioparus | [NiFe] Group 3b | Betaproteobacteria | Hydrogenophilales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_018608874.1 | Uliginosibacterium gangwonense | [NiFe] Group 3b | Betaproteobacteria | Rhodocyclales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_019350089.1 | Fluoribacter dumoffii | [NiFe] Group 3b | Gammaproteobacteria | Legionellales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020123404.1 | Streptomyces canus | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020412786.1 | Microbulbifer variabilis | [NiFe] Group 3b | Gammaproteobacteria | Alteromonadales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
WP_020524726.1 | Catelliglobosispora koreensis | [NiFe] Group 3b | Actinobacteria | Actinomycetales | Bidirectional | Tolerant | 4 | [NiFe]-centre, 3 x [4Fe4S] clusters | Diaphorase, [FeS] protein |
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