This entry was last updated at: Feb. 9, 2018, 7:13 a.m.
Group | [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases |
Subgroup | [NiFe] Group 3a: F420-coupled |
Function | Directly couples oxidation of H2 to reduction of F420 during hydrogenotrophic methanogenesis. Reverse reaction proposed to occur during methylotrophic methanogenesis. Electrons flow between H2-activating hydrogenase subunits to F420 reductase subunit. |
Activity | Bidirectional |
Oxygen tolerance | O2-tolerant |
Localisation | Cytosolic |
Ecosystem distribution | Methanogenic environments such as anoxic soils, marine sediments, and gastrointestinal tracts |
Taxonomic distribution | Encoded in all hydrogenotrophic methanogens |
e.g. Methanothermobacter marburgensis (WP_013296467.1):
Structures | |
Subunits | 3 |
Subunit description | FrhA (hydrogenase large subunit) FrhG (hydrogenase small subunit) FrhB (F420 reductase subunit) |
Catalytic site | [NiFe]-centre or [NiFeSe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] or 3Cys1Asp[4Fe4S] |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_011034943.1 | Methanosarcina mazei | [NiFe] Group 3a | Euryarchaeota | Methanosarcinales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | F420 reductase |
WP_011021012.1 | Methanosarcina acetivorans | [NiFe] Group 3a | Euryarchaeota | Methanosarcinales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | F420 reductase |
WP_011019299.1 | Methanopyrus kandleri | [NiFe] Group 3a | Euryarchaeota | Methanopyrales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | F420 reductase |
WP_010876915.1 | Methanothermobacter thermautotrophicus | [NiFe] Group 3a | Euryarchaeota | Methanobacteriales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | F420 reductase |
WP_007044698.1 | Methanotorris formicicus | [NiFe] Group 3a | Euryarchaeota | Methanococcales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | F420 reductase |
WP_007043840.1 | Methanotorris formicicus | [NiFe] Group 3a | Euryarchaeota | Methanococcales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | F420 reductase |
WP_004591340.1 | Methanocaldococcus villosus | [NiFe] Group 3a | Euryarchaeota | Methanococcales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | F420 reductase |
WP_004076756.1 | Methanoplanus limicola | [NiFe] Group 3a | Euryarchaeota | Methanomicrobiales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | F420 reductase |
WP_004037261.1 | Methanofollis liminatans | [NiFe] Group 3a | Euryarchaeota | Methanomicrobiales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | F420 reductase |
WP_004029354.1 | Methanobacterium formicicum | [NiFe] Group 3a | Euryarchaeota | Methanobacteriales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | F420 reductase |
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