This entry was last updated at: March 2, 2017, 1:49 a.m.
Group | [NiFe] Group 1: Respiratory H2-uptake [NiFe] hydrogenases |
Subgroup | [NiFe] Group 1c: Hyb-type |
Function | Hydrogenotrophic respiration using fumarate, sulfate, or metals as terminal electron acceptors. Route of electron transfer unresolved. Can also fermentatively evolve H2 under hypoxia. |
Activity | H2-uptake (unidirectional) |
Oxygen tolerance | O2-sensitive |
Localisation | Membrane-bound |
Ecosystem distribution | Animal gastrointestinal tracts, anoxic soils and sediments |
Taxonomic distribution | Widespread in Enterobacteria and various sulfate-reducing bacteria |
e.g. Escherichia coli (WP_021568771.1):
Structures |
|
Subunits | 4 |
Subunit description | HybC (hydrogenase large subunit) HybO (hydrogenase small subunit) HybA (iron-sulfur protein and proposed physiological electron acceptor) HybB (transmembrane protein of unresolved function) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: 3Cys[3Fe4S] Distal: 3Cys1His[4Fe4S] |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_000083066.1 | Shigella sonnei | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_002443827.1 | Shimwellia blattae | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004703021.1 | Yersinia aldovae | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005275315.1 | Yersinia bercovieri | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_013650389.1 | Yersinia enterocolitica | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004711883.1 | Yersinia frederiksenii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005188096.1 | Yersinia intermedia | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004389983.1 | Yersinia kristensenii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004877367.1 | Yersinia mollaretii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004716848.1 | Yersinia rohdei | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_006819763.1 | Yokenella regensburgei | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005605173.1 | Actinobacillus pleuropneumoniae | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005576256.1 | Aggregatibacter actinomycetemcomitans | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_012771488.1 | Aggregatibacter aphrophilus | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_006718275.1 | Aggregatibacter segnis | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005638557.1 | Haemophilus haemolyticus | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_014064532.1 | Haemophilus parainfluenzae | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_007243608.1 | Haemophilus pittmaniae | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005760858.1 | Pasteurella bettyae | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_028581743.1 | Desulfobulbus japonicus | [NiFe] Group 1c | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_028579802.1 | Desulfobulbus japonicus | [NiFe] Group 1c | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_028583198.1 | Desulfobulbus mediterraneus | [NiFe] Group 1c | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_015725977.1 | Desulfobulbus propionicus | [NiFe] Group 1c | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_015403419.1 | Desulfocapsa sulfexigens | [NiFe] Group 1c | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_023408348.1 | Desulfofustis sp. PB-SRB1 | [NiFe] Group 1c | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_011187820.1 | Desulfotalea psychrophila | [NiFe] Group 1c | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_010941450.1 | Geobacter sulfurreducens | [NiFe] Group 1c | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_027371077.1 | Desulfovermiculus halophilus | [NiFe] Group 1c | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_012468242.1 | Geobacter lovleyi | [NiFe] Group 1c | Deltaproteobacteria | Desulfuromonadales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_015721386.1 | Geobacter sp. M18 | [NiFe] Group 1c | Deltaproteobacteria | Desulfuromonadales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_012774796.1 | Geobacter sp. M21 | [NiFe] Group 1c | Deltaproteobacteria | Desulfuromonadales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_011938839.1 | Geobacter uraniireducens | [NiFe] Group 1c | Deltaproteobacteria | Desulfuromonadales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_011419537.1 | Anaeromyxobacter dehalogenans | [NiFe] Group 1c | Deltaproteobacteria | Myxococcales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_012098324.1 | Anaeromyxobacter sp. Fw109-5 | [NiFe] Group 1c | Deltaproteobacteria | Myxococcales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_012524582.1 | Anaeromyxobacter sp. K | [NiFe] Group 1c | Deltaproteobacteria | Myxococcales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_013010514.1 | Denitrovibrio acetiphilus | [NiFe] Group 1c | Deferribacteres | Deferribacterales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_013886108.1 | Flexistipes sinusarabici | [NiFe] Group 1c | Deferribacteres | Deferribacterales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_022851983.1 | Geovibrio sp. L21-Ace-BES | [NiFe] Group 1c | Deferribacteres | Deferribacterales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_011466351.1 | Rhodoferax ferrireducens | [NiFe] Group 1c | Betaproteobacteria | Burkholderiales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_009206448.1 | Sulfuricella denitrificans | [NiFe] Group 1c | Betaproteobacteria | Hydrogenophilales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_015437386.1 | Azoarcus sp. KH32C | [NiFe] Group 1c | Betaproteobacteria | Rhodocyclales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_014238024.1 | Azospira oryzae | [NiFe] Group 1c | Betaproteobacteria | Rhodocyclales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_027457220.1 | Dechloromonas agitata | [NiFe] Group 1c | Betaproteobacteria | Rhodocyclales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_011289692.1 | Dechloromonas aromatica | [NiFe] Group 1c | Betaproteobacteria | Rhodocyclales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004378930.1 | Thauera phenylacetica | [NiFe] Group 1c | Betaproteobacteria | Rhodocyclales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_015766767.1 | Accumulibacter phosphatis | [NiFe] Group 1c | Betaproteobacteria | Unclassified | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_022846122.1 | Desulfurobacterium sp. TC5-1 | [NiFe] Group 1c | Aquificae | Desulfurobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_013638066.1 | Desulfurobacterium thermolithotrophum | [NiFe] Group 1c | Aquificae | Desulfurobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_013537874.1 | Thermovibrio ammonificans | [NiFe] Group 1c | Aquificae | Desulfurobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_011714122.1 | Magnetococcus marinus | [NiFe] Group 1c | Alphaproteobacteria | Magnetococcales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
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Physiology:
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