This entry was last updated at: March 2, 2017, 1:49 a.m.
Group | [NiFe] Group 1: Respiratory H2-uptake [NiFe] hydrogenases |
Subgroup | [NiFe] Group 1c: Hyb-type |
Function | Hydrogenotrophic respiration using fumarate, sulfate, or metals as terminal electron acceptors. Route of electron transfer unresolved. Can also fermentatively evolve H2 under hypoxia. |
Activity | H2-uptake (unidirectional) |
Oxygen tolerance | O2-sensitive |
Localisation | Membrane-bound |
Ecosystem distribution | Animal gastrointestinal tracts, anoxic soils and sediments |
Taxonomic distribution | Widespread in Enterobacteria and various sulfate-reducing bacteria |
e.g. Escherichia coli (WP_021568771.1):
Structures |
|
Subunits | 4 |
Subunit description | HybC (hydrogenase large subunit) HybO (hydrogenase small subunit) HybA (iron-sulfur protein and proposed physiological electron acceptor) HybB (transmembrane protein of unresolved function) |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: 3Cys[3Fe4S] Distal: 3Cys1His[4Fe4S] |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_012907588.1 | Citrobacter rodentium | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_006688075.1 | Citrobacter youngae | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_013318689.1 | Dickeya dadantii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_024106579.1 | Dickeya dianthicola | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_022634172.1 | Dickeya solani | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_016941064.1 | Dickeya zeae | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_024522506.1 | Edwardsiella hoshinae | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_015871932.1 | Edwardsiella ictaluri | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005288177.1 | Edwardsiella tarda | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_013366452.1 | Enterobacter lignolyticus | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_027711563.1 | Erwinia chrysanthemi | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_021568771.1 | Escherichia coli | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_000083070.1 | Escherichia fergusonii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_002435491.1 | Escherichia hermannii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004092218.1 | Hafnia alvei | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_007370146.1 | Kosakonia radicincitans | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_027275754.1 | Leminorella grimontii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_011201506.1 | Mannheimia succiniciproducens | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004236380.1 | Morganella morganii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_011092818.1 | Pectobacterium atrosepticum | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_010863700.1 | Plesiomonas shigelloides | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_023580917.1 | Proteus hauseri | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004248989.1 | Proteus mirabilis | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_006535185.1 | Proteus penneri | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_006659162.1 | Providencia alcalifaciens | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_008912430.1 | Providencia burhodogranariea | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004257943.1 | Providencia rettgeri | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_006814152.1 | Providencia rustigianii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_008916675.1 | Providencia sneebia | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_000083035.1 | Salmonella bongori | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_023228387.1 | Salmonella enterica | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_000083052.1 | Shigella boydii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005020299.1 | Shigella dysenteriae | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_000083081.1 | Shigella flexneri | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_000083066.1 | Shigella sonnei | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_002443827.1 | Shimwellia blattae | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004703021.1 | Yersinia aldovae | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005275315.1 | Yersinia bercovieri | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_013650389.1 | Yersinia enterocolitica | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004711883.1 | Yersinia frederiksenii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005188096.1 | Yersinia intermedia | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004389983.1 | Yersinia kristensenii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004877367.1 | Yersinia mollaretii | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_004716848.1 | Yersinia rohdei | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_006819763.1 | Yokenella regensburgei | [NiFe] Group 1c | Gammaproteobacteria | Enterobacteriales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005605173.1 | Actinobacillus pleuropneumoniae | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005576256.1 | Aggregatibacter actinomycetemcomitans | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_012771488.1 | Aggregatibacter aphrophilus | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_006718275.1 | Aggregatibacter segnis | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
WP_005638557.1 | Haemophilus haemolyticus | [NiFe] Group 1c | Gammaproteobacteria | Pasteurellales | Anaerobic Uptake | Sensitive | 4 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | [FeS] protein, TM subunit |
Genetics:
Physiology:
Biochemistry: