This entry was last updated at: Feb. 9, 2018, 7:09 a.m.
Group | [NiFe] Group 1: Respiratory H2-uptake [NiFe] hydrogenases |
Subgroup | [NiFe] Group 1b: Prototypical |
Function | Hydrogenotrophic respiration using sulfate, fumarate, nitrate, metals, and azo compounds as terminal electron acceptors. Enzyme transfers H2-liberated electrons through cytochromes to terminal reductase. |
Activity | H2-uptake (unidirectional) |
Oxygen tolerance | O2-sensitive |
Localisation | Membrane-bound or periplasmic |
Ecosystem distribution | Anoxic soils and sediments, marine waters, animal gastrointestinal tracts |
Taxonomic distribution | Widespread in Deltaproteobacteria and Epsilonproteobacteria |
e.g. Wolinella succinogenes (WP_011139497.1):
Structures |
|
Subunits | 3 |
Subunit description | HynB (hydrogenase large subunit) HynA (hydrogenase small subunit) HynC (cytochrome b subunit) In Deltaproteobacteria, CycA (cytochrome c3 subunit) substitutes for HynC |
Catalytic site | [NiFe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] or 3Cys1Asn[4Fe4S] Medial: 3Cys[3Fe4S] Distal: 3Cys1His[4Fe4S] |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_027191085.1 | Desulfovibrio putealis | [NiFe] Group 1b | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_015851793.1 | Desulfovibrio salexigens | [NiFe] Group 1b | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_020879797.1 | Desulfovibrio sp. X2 | [NiFe] Group 1b | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_010939208.1 | Desulfovibrio vulgaris | [NiFe] Group 1b | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_010939796.1 | Desulfovibrio vulgaris | [NiFe] Group 1b | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_027722919.1 | Desulfovibrio zosterae | [NiFe] Group 1b | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_028324338.1 | Desulfatirhabdium butyrativorans | [NiFe] Group 1b | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_020585310.1 | Desulfobacter curvatus | [NiFe] Group 1b | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_028320012.1 | Desulfobacterium anilini | [NiFe] Group 1b | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_015904103.1 | Desulfobacterium autotrophicum | [NiFe] Group 1b | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_022666958.1 | Desulfospira joergensenii | [NiFe] Group 1b | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_006964156.1 | Desulfotignum phosphitoxidans | [NiFe] Group 1b | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_013163129.1 | Desulfurivibrio alkaliphilus | [NiFe] Group 1b | Epsilonproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_014353799.1 | Sulfobacillus acidophilus | [NiFe] Group 1b | Firmicutes | Clostridiales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_020374232.1 | Sulfobacillus thermosulfidooxidans | [NiFe] Group 1b | Firmicutes | Clostridiales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_027390843.1 | Chrysiogenes arsenatis | [NiFe] Group 1b | Chrysiogenetes | Chrysiogenales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_013505701.1 | Desulfurispirillum indicum | [NiFe] Group 1b | Chrysiogenetes | Chrysiogenales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_014468932.1 | Arcobacter butzleri | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_014468937.1 | Arcobacter butzleri | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_013135169.1 | Arcobacter nitrofigilis | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_013135164.1 | Arcobacter nitrofigilis | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_020975057.1 | Campylobacter coli | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_021091366.1 | Campylobacter concisus | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_027305891.1 | Campylobacter cuniculorum | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_018136329.1 | Campylobacter curvus | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_002849472.1 | Campylobacter fetus | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_005870439.1 | Campylobacter gracilis | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_012108717.1 | Campylobacter hominis | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_002869087.1 | Campylobacter jejuni | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_012661425.1 | Campylobacter lari | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_002952687.1 | Campylobacter showae | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_004277637.1 | Campylobacter upsaliensis | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_016647003.1 | Campylobacter ureolyticus | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_011577655.1 | Helicobacter acinonychis | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_004087140.1 | Helicobacter bilis | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_013890446.1 | Helicobacter bizzozeronii | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_006655925.1 | Helicobacter canadensis | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_023929963.1 | Helicobacter canis | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_014661358.1 | Helicobacter cetorum | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_002956442.1 | Helicobacter cinaedi | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_013469730.1 | Helicobacter felis | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_023949825.1 | Helicobacter fennelliae | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_011114900.1 | Helicobacter hepaticus | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_023926858.1 | Helicobacter macacae | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_013023319.1 | Helicobacter mustelae | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_005020543.1 | Helicobacter pullorum | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_000038050.1 | Helicobacter pylori | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_026944262.1 | Helicobacter rodentium | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_006564409.1 | Helicobacter suis | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
WP_006802201.1 | Helicobacter winghamensis | [NiFe] Group 1b | Epsilonproteobacteria | Campylobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 2 x [4Fe4S] clusters, 1 x [3Fe4S] cluster | Cytochrome |
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