This entry was last updated at: Feb. 9, 2018, 6:58 a.m.
Group | [NiFe] Group 1: Respiratory H2-uptake [NiFe] hydrogenases |
Subgroup | [NiFe] Group 1a: Periplasmic |
Function | Hydrogenotrophic respiration using sulfate, metal, or organohalide compounds as terminal electron acceptors. Enzyme transfers H2-liberated electrons through cytochrome c3 to terminal reductase. |
Activity | H2-uptake (unidirectional) |
Oxygen tolerance | O2-sensitive (NiFe variants) or O2-tolerant (NiFeSe variants) |
Localisation | Periplasmic |
Ecosystem distribution | Anoxic soils and sediments, marine waters, animal gastrointestinal tracts |
Taxonomic distribution | Widespread in sulfate-reducing Deltaproteobacteria and Firmicutes |
e.g. Desulfovibrio vulgaris (WP_010939204.1):
Structures |
|
Subunits | 3 |
Subunit description | HysA (hydrogenase large subunit) HysB (hydrogenase small subunit) CycA (cytochrome c3 subunit) |
Catalytic site | [NiFe]-centre or [NiFeSe]-centre |
FeS clusters | Proximal: 4Cys[4Fe4S] Medial: 4Cys[4Fe4S] Distal: 3Cys1His[4Fe4S] |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_014116604.1 | Oscillibacter valericigenes | [NiFe] Group 1a | Firmicutes | Clostridiales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_017379378.1 | Paenisporosarcina sp. TG-14 | [NiFe] Group 1a | Firmicutes | Clostridiales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_012032862.1 | Pelotomaculum thermopropionicum | [NiFe] Group 1a | Firmicutes | Clostridiales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_013174572.1 | Syntrophothermus lipocalidus | [NiFe] Group 1a | Firmicutes | Clostridiales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_013119172.1 | Thermincola potens | [NiFe] Group 1a | Firmicutes | Clostridiales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_013119653.1 | Thermincola potens | [NiFe] Group 1a | Firmicutes | Clostridiales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_013011808.1 | Denitrovibrio acetiphilus | [NiFe] Group 1a | Deferribacteres | Deferribacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_013885747.1 | Flexistipes sinusarabici | [NiFe] Group 1a | Deferribacteres | Deferribacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_015407385.1 | Dehalococcoides mccartyi | [NiFe] Group 1a | Chloroflexi | Dehalogenimonas | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_013217520.1 | Dehalogenimonas lykanthroporepellens | [NiFe] Group 1a | Chloroflexi | Dehalogenimonas | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_013218717.1 | Dehalogenimonas lykanthroporepellens | [NiFe] Group 1a | Chloroflexi | Dehalogenimonas | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_020589054.1 | Desulfobacter curvatus | [NiFe] Group 1a | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_004071552.1 | Desulfobacter postgatei | [NiFe] Group 1a | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_004072606.1 | Desulfobacter postgatei | [NiFe] Group 1a | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_014959255.1 | Desulfobacula toluolica | [NiFe] Group 1a | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_022664892.1 | Desulfospira joergensenii | [NiFe] Group 1a | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_011187404.1 | Desulfotalea psychrophila | [NiFe] Group 1a | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_024335307.1 | Desulfotignum balticum | [NiFe] Group 1a | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_027365812.1 | Desulfotomaculum alcoholivorax | [NiFe] Group 1a | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_013162757.1 | Desulfurivibrio alkaliphilus | [NiFe] Group 1a | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_029915207.1 | Pelobacter seleniigenes | [NiFe] Group 1a | Deltaproteobacteria | Desulfobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_009380431.1 | Bilophila sp. 4_1_30 | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_009368189.1 | Bilophila sp. 4_1_30 | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_005028324.1 | Bilophila wadsworthia | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_005027974.1 | Bilophila wadsworthia | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_015774148.1 | Desulfomicrobium baculatum | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_028575942.1 | Desulfomicrobium escambiense | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_028573845.1 | Desulfonatronovibrio hydrogenovorans | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_029968792.1 | Desulfonauticus sp. A7A | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_027360998.1 | Desulfovibrio acrylicus | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_014261065.1 | Desulfovibrio africanus | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_011368032.1 | Desulfovibrio alaskensis | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_027178658.1 | Desulfovibrio bastinii | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_020001710.1 | Desulfovibrio desulfuricans | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_015336980.1 | Desulfovibrio hydrothermalis | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_027185047.1 | Desulfovibrio inopinatus | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_006003971.1 | Desulfovibrio piger | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_015851925.1 | Desulfovibrio salexigens | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_010939204.1 | Desulfovibrio vulgaris | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_027722757.1 | Desulfovibrio zosterae | [NiFe] Group 1a | Deltaproteobacteria | Desulfovibrionales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_021169773.1 | Sporomusa ovata | [NiFe] Group 1a | Firmicutes | Selenomonadales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_007288048.1 | Thermosinus carboxydivorans | [NiFe] Group 1a | Firmicutes | Selenomonadales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_015739219.1 | Ammonifex degensii | [NiFe] Group 1a | Firmicutes | Thermoanaerobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_015739752.1 | Ammonifex degensii | [NiFe] Group 1a | Firmicutes | Thermoanaerobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_028052542.1 | Carboxydothermus ferrireducens | [NiFe] Group 1a | Firmicutes | Thermoanaerobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_011344452.1 | Carboxydothermus hydrogenoformans | [NiFe] Group 1a | Firmicutes | Thermoanaerobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_015049787.1 | Thermacetogenium phaeum | [NiFe] Group 1a | Firmicutes | Thermoanaerobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_013755712.1 | Thermodesulfobium narugense | [NiFe] Group 1a | Firmicutes | Thermoanaerobacterales | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
WP_025324287.1 | Deferrisoma camini | [NiFe] Group 1a | Deltaproteobacteria | Unclassified | Anaerobic Uptake | Sensitive | 3 | [NiFe]-centre, 3 x [4Fe4S] clusters | Cytochrome |
Genetics:
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Biochemistry:
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