This entry was last updated at: Feb. 9, 2018, 6:15 a.m.
Group | [FeFe]-hydrogenases |
Subgroup | [FeFe] Group C3: Phosphatase-linked |
Function | Unconfirmed role. May serve as H2-sensors in regulatory cascades. Enzyme predicted to transfer H2-liberated electrons to PAS domain. Associated redox change may modulate activity of associated serine/threonine phosphatase or AAA-type ATPase domains. Members of this class are co-transcribed with fermentative hydrogenases and appear to regulate their transcription. |
Activity | H2-sensing? |
Oxygen tolerance | O2-labile |
Localisation | Cytosolic |
Ecosystem distribution | Gastrointestinal tracts, anoxic soils and sediments |
Taxonomic distribution | Widespread in anaerobic bacteria, including Firmicutes, Deltaproteobacteria, and Spirochaete |
Organisation 1: Ruminococcus albus (WP_002849014.1):
Organisation 2: Geobacter sulfurreducens (WP_014552161.1):
Structures |
|
Subunits | 1 or 3 |
Subunit description | Organisation 1: HydS (catalytic subunit with PAS domain), HydP (serine/threonine phosphatase), HydT (thioredoxin) Organisation 2: HydS fusion (catalytic subunit with PAS domain fused to AAA-type ATPase domain) |
Catalytic site | [FeFe]-centre |
FeS clusters | 2 [4Fe4S] clusters |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_014063294.1 | Thermoanaerobacter wiegelii | [FeFe] Group C3 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | None |
WP_014553745.1 | Halanaerobium praevalens | [FeFe] Group C3 | Firmicutes | Halanaerobiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_014855313.1 | Melioribacter roseus | [FeFe] Group C3 | Ignavibacteriae | Ignavibacteriales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_015325786.1 | Halobacteroides halobius | [FeFe] Group C3 | Firmicutes | Halanaerobiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_015518172.1 | Ruminiclostridium siraeum | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_016777698.1 | Anaerophaga thermohalophila | [FeFe] Group C3 | Bacteroidetes | Bacteroidales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_017416084.1 | Clostridium tunisiense | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_017873317.1 | Caldatribacterium californiense | [FeFe] Group C3 | Atribacteria | Unclassified | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_017890116.1 | Caldatribacterium saccharofermentans | [FeFe] Group C3 | Atribacteria | Unclassified | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_018085928.1 | Desulfurispora thermophila | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_018592801.1 | Terrisporobacter glycolicus | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_019880479.1 | Succinispira mobilis | [FeFe] Group C3 | Firmicutes | Selenomonadales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_023383391.1 | Youngiibacter fragilis | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_026475064.1 | Alkaliflexus imshenetskii | [FeFe] Group C3 | Bacteroidetes | Bacteroidales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_026894719.1 | Clostridiisalibacter paucivorans | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_027356645.1 | Desulfotomaculum thermocisternum | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_027625074.1 | Clostridium lundense | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_027637671.1 | Clostridium cadaveris | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_027718651.1 | Desulfovirgula thermocuniculi | [FeFe] Group C3 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_028828747.1 | Proteocatella sphenisci | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_028992244.1 | Thermoanaerobacter thermocopriae | [FeFe] Group C3 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_004081666.1 | Thermotoga maritima | [FeFe] Group C3 | Thermotogae | Thermotogales | Sensory | Sensitive | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_003543335.1 | Desulfotomaculum nigrificans | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | None |
WP_004514179.1 | Geobacter metallireducens | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_006002638.1 | Desulfuromonas acetoxidans | [FeFe] Group C3 | Deltaproteobacteria | Desulfovibrionales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_006928132.1 | Caldithrix abyssi | [FeFe] Group C3 | Caldithrix | Caldithrixales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with histidine kinase |
WP_008413245.1 | Desulfotomaculum hydrothermale | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | None |
WP_010663847.1 | Marinilabilia salmonicolor | [FeFe] Group C3 | Bacteroidetes | Bacteroidales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_011342071.1 | Pelobacter carbinolicus | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_011393215.1 | Moorella thermoacetica | [FeFe] Group C3 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_011393389.1 | Moorella thermoacetica | [FeFe] Group C3 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_011940950.1 | Geobacter uraniireducens | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_012532230.1 | Geobacter bemidjiensis | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_012635244.1 | Halothermothrix orenii | [FeFe] Group C3 | Firmicutes | Halanaerobiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_012645645.1 | Geobacter daltonii | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_013119651.1 | Thermincola potens | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_013121809.1 | Thermincola potens | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_013406267.1 | Halanaerobium hydrogeniformans | [FeFe] Group C3 | Firmicutes | Halanaerobiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_013484024.1 | Ethanoligenens harbinense | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_013781007.1 | Mahella australiensis | [FeFe] Group C3 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_013810321.1 | Desulfotomaculum carboxydivorans | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | None |
WP_013841414.1 | Desulfotomaculum ruminis | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | None |
WP_014186009.1 | Desulfosporosinus orientis | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_014296384.1 | Marinitoga piezophila | [FeFe] Group C3 | Thermotogae | Thermotogales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with methyl-accepting chemotaxis protein |
WP_014552161.1 | Geobacter sulfurreducens | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_014559402.1 | Ignavibacterium album | [FeFe] Group C3 | Ignavibacteriae | Ignavibacteriales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with histidine kinase |
WP_015722465.1 | Geobacter sp. M18 | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_015839082.1 | Geobacter sp. M21 | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_020675965.1 | Geopsychrobacter electrodiphilus | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_026841112.1 | Geobacter bremensis | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
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