This entry was last updated at: Feb. 9, 2018, 6:15 a.m.
Group | [FeFe]-hydrogenases |
Subgroup | [FeFe] Group C3: Phosphatase-linked |
Function | Unconfirmed role. May serve as H2-sensors in regulatory cascades. Enzyme predicted to transfer H2-liberated electrons to PAS domain. Associated redox change may modulate activity of associated serine/threonine phosphatase or AAA-type ATPase domains. Members of this class are co-transcribed with fermentative hydrogenases and appear to regulate their transcription. |
Activity | H2-sensing? |
Oxygen tolerance | O2-labile |
Localisation | Cytosolic |
Ecosystem distribution | Gastrointestinal tracts, anoxic soils and sediments |
Taxonomic distribution | Widespread in anaerobic bacteria, including Firmicutes, Deltaproteobacteria, and Spirochaete |
Organisation 1: Ruminococcus albus (WP_002849014.1):
Organisation 2: Geobacter sulfurreducens (WP_014552161.1):
Structures |
|
Subunits | 1 or 3 |
Subunit description | Organisation 1: HydS (catalytic subunit with PAS domain), HydP (serine/threonine phosphatase), HydT (thioredoxin) Organisation 2: HydS fusion (catalytic subunit with PAS domain fused to AAA-type ATPase domain) |
Catalytic site | [FeFe]-centre |
FeS clusters | 2 [4Fe4S] clusters |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_012635137.1 | Halothermothrix orenii | [FeFe] Group C3 | Firmicutes | Halanaerobiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_012635165.1 | Halothermothrix orenii | [FeFe] Group C3 | Firmicutes | Halanaerobiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_012635244.1 | Halothermothrix orenii | [FeFe] Group C3 | Firmicutes | Halanaerobiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_013406267.1 | Halanaerobium hydrogeniformans | [FeFe] Group C3 | Firmicutes | Halanaerobiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_014553745.1 | Halanaerobium praevalens | [FeFe] Group C3 | Firmicutes | Halanaerobiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_015325786.1 | Halobacteroides halobius | [FeFe] Group C3 | Firmicutes | Halanaerobiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_012862884.1 | Sebaldella termitidis | [FeFe] Group C3 | Fusobacteria | Fusobacteriales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_013387666.1 | Ilyobacter polytropus | [FeFe] Group C3 | Fusobacteria | Fusobacteriales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_006059864.1 | Holdemania filiformis | [FeFe] Group C3 | Firmicutes | Erysipelotrichales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_006784034.1 | Turicibacter sanguinis | [FeFe] Group C3 | Firmicutes | Erysipelotrichales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_012414922.1 | Elusimicrobium minutum | [FeFe] Group C3 | Elusimicrobia | Elusimicrobiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_012547917.1 | Dictyoglomus thermophilum | [FeFe] Group C3 | Dictyoglomi | Dictyoglomales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_012582931.1 | Dictyoglomus turgidum | [FeFe] Group C3 | Dictyoglomi | Dictyoglomales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_004514179.1 | Geobacter metallireducens | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_011341577.1 | Pelobacter carbinolicus | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_011342071.1 | Pelobacter carbinolicus | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_011940950.1 | Geobacter uraniireducens | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_012532230.1 | Geobacter bemidjiensis | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_012645645.1 | Geobacter daltonii | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_014552161.1 | Geobacter sulfurreducens | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_015722465.1 | Geobacter sp. M18 | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_015839082.1 | Geobacter sp. M21 | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_020675965.1 | Geopsychrobacter electrodiphilus | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_026841112.1 | Geobacter bremensis | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_029918197.1 | Pelobacter seleniigenes | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_015839082.1 | Geobacter sp. M21 | [FeFe] Group C3 | Deltaproteobacteria | Desulfuromonadales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_005996231.1 | Desulfovibrio fructosivorans | [FeFe] Group C3 | Deltaproteobacteria | Desulfovibrionales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_006002638.1 | Desulfuromonas acetoxidans | [FeFe] Group C3 | Deltaproteobacteria | Desulfovibrionales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Fusion with transcriptional activator |
WP_011698701.1 | Syntrophobacter fumaroxidans | [FeFe] Group C3 | Deltaproteobacteria | Desulfovibrionales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_024823816.1 | Desulfovibrio magneticus | [FeFe] Group C3 | Deltaproteobacteria | Desulfovibrionales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_029460054.1 | Desulfovibrio alcoholivorans | [FeFe] Group C3 | Deltaproteobacteria | Desulfovibrionales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_015724298.1 | Desulfobulbus propionicus | [FeFe] Group C3 | Deltaproteobacteria | Desulfobacterales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_002568890.1 | Lachnoclostridium bolteae | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_002849014.1 | Ruminococcus albus | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_003493654.1 | Clostridium sporogenes | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_003493657.1 | Clostridium sporogenes | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_003499089.1 | Lachnoclostridium symbiosum | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_003507891.1 | Lachnoclostridium symbiosum | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_003543335.1 | Desulfotomaculum nigrificans | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 1 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | None |
WP_003543972.1 | Desulfotomaculum nigrificans | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_004608289.1 | Lachnoclostridium scindens | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_004614045.1 | Tyzzerella nexilis | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_004629692.1 | Ruminiclostridium termitidis | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_006442325.1 | Lachnoclostridium hylemonae | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_006524079.1 | Desulfotomaculum gibsoniae | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_006574746.1 | Pseudoflavonifractor capillosus | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_006778911.1 | Lachnoclostridium hathewayi | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_006874783.1 | Anaerotruncus colihominis | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase, thioredoxin |
WP_007059414.1 | Clostridium carboxidivorans | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
WP_007287482.1 | Intestinibacter bartlettii | [FeFe] Group C3 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Phosphatase |
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