This entry was last updated at: Feb. 9, 2018, 6:15 a.m.
Group | [FeFe]-hydrogenases |
Subgroup | [FeFe] Group C1: Histidine kinase-linked |
Function | Unconfirmed role. May serve as H2-sensors in regulatory cascades. Enzyme predicted to transfer H2-liberated electrons to PAS domain. Associated redox change may modulate activity of associated histidine kinase and in turn transcription if other hydrogenases. |
Activity | H2-sensing? |
Oxygen tolerance | O2-labile |
Localisation | Cytosolic |
Ecosystem distribution | Gastrointestinal tracts, anoxic soils and sediments |
Taxonomic distribution | Encoded in anaerobic bacteria, including Firmicutes and Bacteroidetes |
e.g. Acetobacterium woodii (WP_014357055.1):
Structures |
|
Subunits | 2 |
Subunit description | HydS (catalytic subunit with PAS domain) HydK (histidine kinase) |
Catalytic site | [FeFe]-centre |
FeS clusters | 2 [4Fe4S] clusters |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_019541391.1 | Proteiniphilum acetatigenes | [FeFe] Group C1 | Bacteroidetes | Bacteroidales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_006573282.1 | Pseudoflavonifractor capillosus | [FeFe] Group C1 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_027629168.1 | Ruminiclostridium cellobioparum | [FeFe] Group C1 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_014254572.1 | Ruminiclostridium clariflavum | [FeFe] Group C1 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_003534146.1 | Ruminiclostridium leptum | [FeFe] Group C1 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_015358348.1 | Ruminiclostridium stercorarium | [FeFe] Group C1 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_004626210.1 | Ruminiclostridium termitidis | [FeFe] Group C1 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_003512576.1 | Ruminiclostridium thermocellum | [FeFe] Group C1 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_021167205.1 | Sporomusa ovata | [FeFe] Group C1 | Firmicutes | Selenomonadales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_013778946.1 | Tepidanaerobacter acetatoxydans | [FeFe] Group C1 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_003871510.1 | Thermoanaerobacter ethanolicus | [FeFe] Group C1 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_012994906.1 | Thermoanaerobacter italicus | [FeFe] Group C1 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_013150113.1 | Thermoanaerobacter mathranii | [FeFe] Group C1 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_006570151.1 | Thermoanaerobacter siderophilus | [FeFe] Group C1 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_028991495.1 | Thermoanaerobacter thermocopriae | [FeFe] Group C1 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_004401673.1 | Thermoanaerobacter thermohydrosulfuricus | [FeFe] Group C1 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_014062652.1 | Thermoanaerobacter wiegelii | [FeFe] Group C1 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_014758976.1 | Thermoanaerobacterium saccharolyticum | [FeFe] Group C1 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_013297601.1 | Thermoanaerobacterium thermosaccharolyticum | [FeFe] Group C1 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_013788354.1 | Thermoanaerobacterium xylanolyticum | [FeFe] Group C1 | Firmicutes | Thermoanaerobacterales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_018660455.1 | Thermobrachium celere | [FeFe] Group C1 | Firmicutes | Clostridiales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_007288806.1 | Thermosinus carboxydivorans | [FeFe] Group C1 | Firmicutes | Selenomonadales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
WP_014163756.1 | Thermovirga lienii | [FeFe] Group C1 | Synergistetes | Synergistales | Sensory | Labile | 2 | [FeFe]-centre, 2 x [4Fe4S] clusters, PAS domain | Histidine kinase |
Genetics: