[FeFe] Group B-hydrogenase Putative

This entry was last updated at: Feb. 9, 2018, 6:17 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group B: Colonic-type
Function Unconfirmed role. Indirect evidence suggests the hydrogenase is involved in hydrogenogenic fermentation. It may couple reoxidation of ferredoxinred to the evolution of H2.
Activity H2-evolution?
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Widespread in colonic Bacteroides, Clostridia, and Actinobacteria
Genetic Organisation

Organisation 1: Clostridium pasteurianum (WP_023976023.1):


Organisation 2: Clostridium carboxyidovorans (WP_007061531.1):

Architecture
Structures
    None
Subunits 1
Subunit description HydM (catalytic subunit)
Catalytic site [FeFe]-centre
FeS clusters Organisation 1: 2 [4Fe4S] clusters
Organisation 2: 3 [4Fe4S] clusters, 1 [2Fe2S] cluste
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_008724767.1Brachyspira hampsonii[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_010699218.1Treponema denticola[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_012670335.1Brachyspira hyodysenteriae[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013243002.1Brachyspira pilosicoli[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013255832.1Spirochaeta smaragdinae[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013608539.1Sphaerochaeta globosa[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013700376.1Treponema succinifaciens[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014270720.1Sphaerochaeta pleomorpha[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014487517.1Brachyspira intermedia[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_015710040.1Treponema azotonutricium[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_018526486.1Spirochaeta alkalica[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_020005910.1Brachyspira innocens[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_022931411.1Treponema bryantii[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_028329580.1Brachyspira alvinipulli[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_008713427.1Synergistes sp. 3_1_syn1[FeFe] Group BSynergistetesSynergistalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013150225.1Thermoanaerobacter mathranii[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013276251.1Thermosediminibacter oceani[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_013298245.1Thermoanaerobacterium thermosaccharolyticum[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013788347.1Thermoanaerobacterium xylanolyticum[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014063301.1Thermoanaerobacter wiegelii[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterPhosphatase
WP_014758430.1Thermoanaerobacterium saccharolyticum[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_015869123.1Kosmotoga olearia[FeFe] Group BThermotogaeThermotogalesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone

Literature

Genetics:

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Physiology: