[FeFe] Group B-hydrogenase Putative

This entry was last updated at: Feb. 9, 2018, 6:17 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group B: Colonic-type
Function Unconfirmed role. Indirect evidence suggests the hydrogenase is involved in hydrogenogenic fermentation. It may couple reoxidation of ferredoxinred to the evolution of H2.
Activity H2-evolution?
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Widespread in colonic Bacteroides, Clostridia, and Actinobacteria
Genetic Organisation

Organisation 1: Clostridium pasteurianum (WP_023976023.1):


Organisation 2: Clostridium carboxyidovorans (WP_007061531.1):

Architecture
Structures
    None
Subunits 1
Subunit description HydM (catalytic subunit)
Catalytic site [FeFe]-centre
FeS clusters Organisation 1: 2 [4Fe4S] clusters
Organisation 2: 3 [4Fe4S] clusters, 1 [2Fe2S] cluste
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_015360284.1Ruminiclostridium stercorarium[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015359535.1Ruminiclostridium stercorarium[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_015326565.1Halobacteroides halobius[FeFe] Group BFirmicutesHalanaerobialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_015325789.1Halobacteroides halobius[FeFe] Group BFirmicutesHalanaerobialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_015261135.1Desulfitobacterium dichloroeliminans[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014904712.1Desulfosporosinus meridiei[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014792843.1Desulfitobacterium dehalogenans[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014792620.1Desulfitobacterium dehalogenans[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014758430.1Thermoanaerobacterium saccharolyticum[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014553922.1Halanaerobium praevalens[FeFe] Group BFirmicutesHalanaerobialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014553742.1Halanaerobium praevalens[FeFe] Group BFirmicutesHalanaerobialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014487517.1Brachyspira intermedia[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014299406.1Bacteroides fragilis[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014270720.1Sphaerochaeta pleomorpha[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014261748.1Filifactor alocis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014128295.1Acidaminococcus intestini[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014115957.1Oscillibacter valericigenes[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014080018.1Roseburia hominis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_014079355.1Roseburia hominis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_014063301.1Thermoanaerobacter wiegelii[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterPhosphatase
WP_014015718.1Megasphaera elsdenii[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_013842589.1Desulfotomaculum ruminis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_013842190.1Desulfotomaculum ruminis[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013810136.1Desulfotomaculum carboxydivorans[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013809931.1Desulfotomaculum carboxydivorans[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_013788347.1Thermoanaerobacterium xylanolyticum[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013760215.1Porphyromonas asaccharolytica[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013708979.1Coriobacterium glomerans[FeFe] Group BActinobacteriaCoriobacterialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_013700376.1Treponema succinifaciens[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013657049.1Cellulosilyticum lentocellum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_013613424.1Odoribacter splanchnicus[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013608539.1Sphaerochaeta globosa[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013547705.1Bacteroides helcogenes[FeFe] Group BBacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013486531.1Ethanoligenens harbinense[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013484003.1Ethanoligenens harbinense[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_013387868.1Ilyobacter polytrophus[FeFe] Group BFusobacteriaFusobacterialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_013380841.1Eubacterium limosum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_013298245.1Thermoanaerobacterium thermosaccharolyticum[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013276251.1Thermosediminibacter oceani[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_013274254.1Lachnoclostridium saccharolyticum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_013273992.1Lachnoclostridium saccharolyticum[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013255832.1Spirochaeta smaragdinae[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013252233.1Olsenella uli[FeFe] Group BActinobacteriaCoriobacterialesEvolvingLabile1[FeFe]-centre, 2 x [4Fe4S] clustersNone
WP_013243002.1Brachyspira pilosicoli[FeFe] Group BSpirochaetesSpirochaetalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013240326.1Clostridium ljungdahlii[FeFe] Group BFirmicutesClostridialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_013150225.1Thermoanaerobacter mathranii[FeFe] Group BFirmicutesThermoanaerobacteralesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_012939228.1 Acidaminococcus fermentans[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_012939228.1Acidaminococcus fermentans[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_012938875.1Acidaminococcus fermentans[FeFe] Group BFirmicutesSelenomonadalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_012862886.1Sebaldella termitidis[FeFe] Group BFusobacteriaFusobacterialesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone

Literature

Genetics:

,

Physiology: