[FeFe] Group A3-hydrogenase

This entry was last updated at: Feb. 9, 2018, 6:46 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group A3: Bifurcating
Function Bifurcates electrons from H2 to NAD and ferredoxin. Reverse reaction can also occur resulting in reoxidation of redox carriers concomitant with fermentative H2 evolution.
Activity Electron-bifurcation
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Widespread in anaerobic bacteria, including Firmicutes, Bacteroidetes, Deltaproteobacteria, and Spirochaetes
Genetic Organisation

Organisation 1: Thermotoga maritima (WP_004081677.1):


Organisation 2: Desulfovibrio fructosovorans (WP_005990603.1):

Architecture
Structures
    None
Subunits 3 or 4
Subunit description HydA (catalytic subunit)
HydB (diaphorase subunit)
HydC (thioredoxin)
In organisation 2, an additional thioredoxin (HydD) is present
Catalytic site [FeFe]-centre
FeS clusters Organisation 1: 3 [4Fe4S] clusters, 2 [2Fe2S] clusters
Organisation 2: 3 [4Fe4S] clusters, 1 [2Fe2S] cluster
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_005033810.1Holophaga foetida[FeFe] Group A3AcidobacteriaHolophagalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_005034114.1Holophaga foetida[FeFe] Group A3AcidobacteriaHolophagalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_005038259.1Holophaga foetida[FeFe] Group A3AcidobacteriaHolophagalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 2 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_024286588.1Cellulomonas sp. KRMCY2[FeFe] Group A3ActinobacteriaActinomycetalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_002730048.1Phaeospirillum molischianum[FeFe] Group A3AlphaproteobacteriaRhodospirillalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_014413848.1Rhodospirillum photometricum[FeFe] Group A3AlphaproteobacteriaRhodospirillalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_021133133.1Phaeospirillum fulvum[FeFe] Group A3AlphaproteobacteriaRhodospirillalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_022000256.1Acetobacter sp. CAG:977[FeFe] Group A3AlphaproteobacteriaRhodospirillalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_022196619.1Azospirillum sp. CAG:239[FeFe] Group A3AlphaproteobacteriaRhodospirillalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_022418208.1Acidiphilium sp. CAG:727[FeFe] Group A3AlphaproteobacteriaRhodospirillalesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_026781963.1Pleomorphomonas koreensis[FeFe] Group A3AlphaproteobacteriaRhizobialesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_026791754.1Pleomorphomonas oryzae[FeFe] Group A3AlphaproteobacteriaRhizobialesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_013637757.1Desulfurobacterium thermolithotrophum[FeFe] Group A3AquificaeDesulfurobacterialesBifurcatingLabile3[FeFe]-centre, 2 x [4Fe4S] clustersNADH dehydrogenase, thioredoxin
WP_022847517.1Desulfurobacterium sp. TC5-1[FeFe] Group A3AquificaeDesulfurobacterialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_016268012.1Bacteroides thetaiotaomicron[FeFe] Group A3BacteroidetesBacteroidalesEvolvingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNone
WP_021646890.1Bacteroides pyogenes[FeFe] Group A3BacteroidetesBacteroidalesEvolvingLabile2[FeFe]-centre, 2 x [4Fe4S] clustersSmall subunit
WP_004319661.1Bacteroides ovatus[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_004329321.1Alistipes putredinis[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_005643305.1Parabacteroides merdae[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_005680505.1Bacteroides caccae[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_005836595.1Bacteroides uniformis[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_005931733.1Bacteroides salyersiae[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_005941255.1Bacteroides massiliensis[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_007216264.1Bacteroides cellulosilyticus[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_007656765.1Parabacteroides goldsteinii[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_008021616.1Bacteroides xylanisolvens[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_008157755.1Parabacteroides johnsonii[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_009132358.1Bacteroides oleiciplenus[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_010537425.1Bacteroides faecis[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_010663850.1Marinilabilia salmonicolor[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_010665320.1Marinilabilia salmonicolor[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_013610540.1Odoribacter splanchnicus[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_016777708.1Anaerophaga thermohalophila[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_018336996.1Butyricimonas synergistica[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_024986193.1Bacteroides acidifaciens[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_025863481.1Prolixibacter bellariivorans[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_025863484.1Prolixibacter bellariivorans[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_025867773.1Bacteroides nordii[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_026327676.1Proteiniphilum acetatigenes[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_026475062.1Alkaliflexus imshenetskii[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_026475073.1Alkaliflexus imshenetskii[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_027199847.1Butyricimonas virosa[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_027326146.1Bacteroides pyogenes[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_027472107.1Cytophaga fermentans[FeFe] Group A3BacteroidetesCytophagalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_028729360.1Parabacteroides gordonii[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_006928134.1Caldithrix abyssi[FeFe] Group A3CaldithrixCaldithrixalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_010935952.1Dehalococcoides mccartyi[FeFe] Group A3ChloroflexiDehalococcoidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_022849147.1Chloroflexi sp. 439[FeFe] Group A3ChloroflexiUnclassifiedBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_015424900.1Cloacimonas acidaminovorans[FeFe] Group A3CloacimonetesUnclassifiedBifurcatingLabile1[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_005990603.1Desulfovibrio fructosivorans[FeFe] Group A3DeltaproteobacteriaDesulfovibrionalesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin

Literature

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