This entry was last updated at: Feb. 9, 2018, 6:46 a.m.
Group | [FeFe]-hydrogenases |
Subgroup | [FeFe] Group A3: Bifurcating |
Function | Bifurcates electrons from H2 to NAD and ferredoxin. Reverse reaction can also occur resulting in reoxidation of redox carriers concomitant with fermentative H2 evolution. |
Activity | Electron-bifurcation |
Oxygen tolerance | O2-labile |
Localisation | Cytosolic |
Ecosystem distribution | Gastrointestinal tracts, anoxic soils and sediments |
Taxonomic distribution | Widespread in anaerobic bacteria, including Firmicutes, Bacteroidetes, Deltaproteobacteria, and Spirochaetes |
Organisation 1: Thermotoga maritima (WP_004081677.1):
Organisation 2: Desulfovibrio fructosovorans (WP_005990603.1):
Structures |
|
Subunits | 3 or 4 |
Subunit description | HydA (catalytic subunit) HydB (diaphorase subunit) HydC (thioredoxin) In organisation 2, an additional thioredoxin (HydD) is present |
Catalytic site | [FeFe]-centre |
FeS clusters | Organisation 1: 3 [4Fe4S] clusters, 2 [2Fe2S] clusters Organisation 2: 3 [4Fe4S] clusters, 1 [2Fe2S] cluster |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_006352890.1 | Ruminiclostridium methylpentosum | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 4 | [FeFe]-centre, 2 x [4Fe4S] clusters | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_020814848.1 | Ruminiclostridium papyrosolvens | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_020815562.1 | Ruminiclostridium papyrosolvens | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_020815721.1 | Ruminiclostridium papyrosolvens | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_015518595.1 | Ruminiclostridium siraeum | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_015358633.1 | Ruminiclostridium stercorarium | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_004629507.1 | Ruminiclostridium termitidis | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_004630049.1 | Ruminiclostridium termitidis | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_003512584.1 | Ruminiclostridium thermocellum | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_003519061.1 | Ruminiclostridium thermocellum | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_027096606.1 | Ruminiclostridium viride | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_002853139.1 | Ruminococcus albus | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_028515986.1 | Ruminococcus flavefaciens | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_023920491.1 | Ruminococcus lactaris | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_012860094.1 | Sebaldella termitidis | [FeFe] Group A3 | Fusobacteria | Fusobacteriales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_012863017.1 | Sebaldella termitidis | [FeFe] Group A3 | Fusobacteria | Fusobacteriales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_014425762.1 | Selenomonas ruminantium | [FeFe] Group A3 | Firmicutes | Selenomonadales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_006191642.1 | Selenomonas sputigena | [FeFe] Group A3 | Firmicutes | Selenomonadales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_013607267.1 | Sphaerochaeta globosa | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_013607980.1 | Sphaerochaeta globosa | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_014271080.1 | Sphaerochaeta pleomorpha | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_014455790.1 | Spirochaeta africana | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_014456422.1 | Spirochaeta africana | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_018525843.1 | Spirochaeta alkalica | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_020611046.1 | Spirochaeta bajacaliforniensis | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 2 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_020611343.1 | Spirochaeta bajacaliforniensis | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_020614051.1 | Spirochaeta bajacaliforniensis | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_028972813.1 | Spirochaeta cellobiosiphila | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_013252975.1 | Spirochaeta smaragdinae | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 2 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_013253085.1 | Spirochaeta smaragdinae | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_013256232.1 | Spirochaeta smaragdinae | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_013313426.1 | Spirochaeta thermophila | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_013314154.1 | Spirochaeta thermophila | [FeFe] Group A3 | Spirochaetes | Spirochaetales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_021167212.1 | Sporomusa ovata | [FeFe] Group A3 | Firmicutes | Selenomonadales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_021169841.1 | Sporomusa ovata | [FeFe] Group A3 | Firmicutes | Selenomonadales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_028043706.1 | Stoquefichus massiliensis | [FeFe] Group A3 | Firmicutes | Erysipelotrichales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_019879374.1 | Succinispira mobilis | [FeFe] Group A3 | Firmicutes | Selenomonadales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_008708834.1 | Synergistes sp. 3_1_syn1 | [FeFe] Group A3 | Synergistetes | Synergistales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_008711190.1 | Synergistes sp. 3_1_syn1 | [FeFe] Group A3 | Synergistetes | Synergistales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_011697714.1 | Syntrophobacter fumaroxidans | [FeFe] Group A3 | Deltaproteobacteria | Syntrophobacterales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_013625341.1 | Syntrophobotulus glycolicus | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | NADH dehydrogenase, thioredoxin |
WP_013625342.1 | Syntrophobotulus glycolicus | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | NADH dehydrogenase, thioredoxin |
WP_013626003.1 | Syntrophobotulus glycolicus | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 4 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin, thioredoxin |
WP_011640436.1 | Syntrophomonas wolfei | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_028893663.1 | Syntrophorhabdus aromaticivorans | [FeFe] Group A3 | Deltaproteobacteria | Syntrophobacterales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_028893679.1 | Syntrophorhabdus aromaticivorans | [FeFe] Group A3 | Deltaproteobacteria | Syntrophobacterales | Bifurcating | Labile | 3 | [FeFe]-centre, 2 x [4Fe4S] clusters | NADH dehydrogenase, thioredoxin |
WP_013174729.1 | Syntrophothermus lipocalidus | [FeFe] Group A3 | Firmicutes | Clostridiales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_011417004.1 | Syntrophus aciditrophicus | [FeFe] Group A3 | Deltaproteobacteria | Syntrophobacterales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_013778939.1 | Tepidanaerobacter acetatoxydans | [FeFe] Group A3 | Firmicutes | Thermoanaerobacterales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
WP_013779523.1 | Tepidanaerobacter acetatoxydans | [FeFe] Group A3 | Firmicutes | Thermoanaerobacterales | Bifurcating | Labile | 3 | [FeFe]-centre, 3 x [4Fe4S] clusters, 2 x [2Fe2S] cluster | NADH dehydrogenase, thioredoxin |
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