[FeFe] Group A3-hydrogenase

This entry was last updated at: Feb. 9, 2018, 6:46 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group A3: Bifurcating
Function Bifurcates electrons from H2 to NAD and ferredoxin. Reverse reaction can also occur resulting in reoxidation of redox carriers concomitant with fermentative H2 evolution.
Activity Electron-bifurcation
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Widespread in anaerobic bacteria, including Firmicutes, Bacteroidetes, Deltaproteobacteria, and Spirochaetes
Genetic Organisation

Organisation 1: Thermotoga maritima (WP_004081677.1):


Organisation 2: Desulfovibrio fructosovorans (WP_005990603.1):

Architecture
Structures
    None
Subunits 3 or 4
Subunit description HydA (catalytic subunit)
HydB (diaphorase subunit)
HydC (thioredoxin)
In organisation 2, an additional thioredoxin (HydD) is present
Catalytic site [FeFe]-centre
FeS clusters Organisation 1: 3 [4Fe4S] clusters, 2 [2Fe2S] clusters
Organisation 2: 3 [4Fe4S] clusters, 1 [2Fe2S] cluster
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_015925885.1Clostridium cellulolyticum[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_016182069.1Enterococcus avium[FeFe] Group A3FirmicutesLactobacillalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_016206177.1Clostridium sartagoforme[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_016314690.1Paenibacillus barengoltzii[FeFe] Group A3FirmicutesBacillalesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_016777708.1Anaerophaga thermohalophila[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_017416132.1Clostridium tunisiense[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_017416926.1Clostridium tunisiense[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_018084282.1Desulfurispora thermophila[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_018086225.1Desulfurispora thermophila[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_018249206.1Orenia marismortui[FeFe] Group A3FirmicutesHalanaerobialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_018336996.1Butyricimonas synergistica[FeFe] Group A3BacteroidetesBacteroidalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_018525843.1Spirochaeta alkalica[FeFe] Group A3SpirochaetesSpirochaetalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_018592006.1Terrisporobacter glycolicus[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_018660435.1Thermobrachium celere[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_018662721.1Thermobrachium celere[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_018962529.1Coprothermobacter platensis[FeFe] Group A3FirmicutesThermoanaerobacteralesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_019225264.1Dehalobacter sp. E1[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_019225315.1Dehalobacter sp. E1[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_019225928.1Dehalobacter sp. E1[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_019552746.1Zymophilus raffinosivorans[FeFe] Group A3FirmicutesSelenomonadalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_019554879.1Zymophilus raffinosivorans[FeFe] Group A3FirmicutesSelenomonadalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_019879374.1Succinispira mobilis[FeFe] Group A3FirmicutesSelenomonadalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_020003846.1Brachyspira innocens[FeFe] Group A3SpirochaetesSpirochaetalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_020490880.1Dehalobacter sp. FTH1[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_020491838.1Dehalobacter sp. FTH1[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_020611343.1Spirochaeta bajacaliforniensis[FeFe] Group A3SpirochaetesSpirochaetalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_020614051.1Spirochaeta bajacaliforniensis[FeFe] Group A3SpirochaetesSpirochaetalesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_020814848.1Ruminiclostridium papyrosolvens[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_020815562.1Ruminiclostridium papyrosolvens[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_020815721.1Ruminiclostridium papyrosolvens[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_021133133.1Phaeospirillum fulvum[FeFe] Group A3AlphaproteobacteriaRhodospirillalesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_021167212.1Sporomusa ovata[FeFe] Group A3FirmicutesSelenomonadalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_021169841.1Sporomusa ovata[FeFe] Group A3FirmicutesSelenomonadalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_021434166.1Peptoclostridium bifermentans[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_021739954.1Eubacterium ramulus[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_021767225.1Leptotrichia sp. 215[FeFe] Group A3FusobacteriaFusobacterialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_021803813.1Clostridium intestinale[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_022000256.1Acetobacter sp. CAG:977[FeFe] Group A3AlphaproteobacteriaRhodospirillalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_022196619.1Azospirillum sp. CAG:239[FeFe] Group A3AlphaproteobacteriaRhodospirillalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_022418208.1Acidiphilium sp. CAG:727[FeFe] Group A3AlphaproteobacteriaRhodospirillalesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_022636475.1Chitinivibrio alkaliphilus[FeFe] Group A3FibrobacteresChitinivibrionalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_022847517.1Desulfurobacterium sp. TC5-1[FeFe] Group A3AquificaeDesulfurobacterialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_022849147.1Chloroflexi sp. 439[FeFe] Group A3ChloroflexiUnclassifiedBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_023051856.1Cetobacterium somerae[FeFe] Group A3FusobacteriaFusobacterialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_023052447.1Cetobacterium somerae[FeFe] Group A3FusobacteriaFusobacterialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_023162310.1Clostridium autoethanogenum[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_023163243.1Clostridium autoethanogenum[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_023388223.1Youngiibacter fragilis[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_023388270.1Youngiibacter fragilis[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_023920491.1Ruminococcus lactaris[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin

Literature

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