[FeFe] Group A3-hydrogenase

This entry was last updated at: Feb. 9, 2018, 6:46 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group A3: Bifurcating
Function Bifurcates electrons from H2 to NAD and ferredoxin. Reverse reaction can also occur resulting in reoxidation of redox carriers concomitant with fermentative H2 evolution.
Activity Electron-bifurcation
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Widespread in anaerobic bacteria, including Firmicutes, Bacteroidetes, Deltaproteobacteria, and Spirochaetes
Genetic Organisation

Organisation 1: Thermotoga maritima (WP_004081677.1):


Organisation 2: Desulfovibrio fructosovorans (WP_005990603.1):

Architecture
Structures
    None
Subunits 3 or 4
Subunit description HydA (catalytic subunit)
HydB (diaphorase subunit)
HydC (thioredoxin)
In organisation 2, an additional thioredoxin (HydD) is present
Catalytic site [FeFe]-centre
FeS clusters Organisation 1: 3 [4Fe4S] clusters, 2 [2Fe2S] clusters
Organisation 2: 3 [4Fe4S] clusters, 1 [2Fe2S] cluster
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_013809932.1Desulfotomaculum carboxydivorans[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 2 x [4Fe4S] clustersNADH dehydrogenase, thioredoxin
WP_013810075.1Desulfotomaculum carboxydivorans[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 2 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_013810492.1Desulfotomaculum carboxydivorans[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase
WP_013823357.1Desulfotomaculum kuznetsovii[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_013824004.1Desulfotomaculum kuznetsovii[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 2 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_013840577.1Desulfotomaculum ruminis[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_013842391.1Desulfotomaculum ruminis[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 2 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_013842395.1Desulfotomaculum ruminis[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_013842583.1Desulfotomaculum ruminis[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 2 x [4Fe4S] clustersNADH dehydrogenase, thioredoxin
WP_013843380.1Desulfotomaculum ruminis[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 2 x [4Fe4S] clustersNADH dehydrogenase, thioredoxin
WP_014062655.1Thermoanaerobacter wiegelii[FeFe] Group A3FirmicutesThermoanaerobacteralesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_014117537.1Oscillibacter valericigenes[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_014184036.1Desulfosporosinus orientis[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_014187152.1Desulfosporosinus orientis[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 2 x [4Fe4S] clustersNADH dehydrogenase, thioredoxin
WP_014187542.1Desulfosporosinus orientis[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_014254579.1Ruminiclostridium clariflavum[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_014357048.1Acetobacterium woodii[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_014425762.1Selenomonas ruminantium[FeFe] Group A3FirmicutesSelenomonadalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_014553773.1Halanaerobium praevalens[FeFe] Group A3FirmicutesHalanaerobialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_014758969.1Thermoanaerobacterium saccharolyticum[FeFe] Group A3FirmicutesThermoanaerobacteralesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_014792559.1Desulfitobacterium dehalogenans[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_014795695.1Desulfitobacterium dehalogenans[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 2 x [4Fe4S] clustersNADH dehydrogenase, thioredoxin
WP_014901644.1Desulfosporosinus meridiei[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_014902186.1Desulfosporosinus meridiei[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 2 x [4Fe4S] clustersNADH dehydrogenase, thioredoxin
WP_014905079.1Desulfosporosinus meridiei[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_015326098.1Halobacteroides halobius[FeFe] Group A3FirmicutesHalanaerobialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_015327873.1Halobacteroides halobius[FeFe] Group A3FirmicutesHalanaerobialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_015358633.1Ruminiclostridium stercorarium[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_015394438.1Clostridium saccharoperbutylacetonicum[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_015513462.1Coprococcus catus[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_015518595.1Ruminiclostridium siraeum[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_015528256.1Lachnoclostridium torques[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_015738331.1Ammonifex degensii[FeFe] Group A3FirmicutesThermoanaerobacteralesBifurcatingLabile3[FeFe]-centre, 2 x [4Fe4S] clustersNADH dehydrogenase, thioredoxin
WP_015739748.1Ammonifex degensii[FeFe] Group A3FirmicutesThermoanaerobacteralesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_015759215.1Desulfotomaculum acetoxidans[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_015778015.1Anaerococcus prevotii[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_015907776.1Caldicellulosiruptor bescii[FeFe] Group A3FirmicutesThermoanaerobacteralesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_015925666.1Clostridium cellulolyticum[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_015925732.1Clostridium cellulolyticum[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_015925885.1Clostridium cellulolyticum[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_015945352.1Desulfitobacterium hafniense[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 2 x [4Fe4S] clustersNADH dehydrogenase, thioredoxin
WP_016182069.1Enterococcus avium[FeFe] Group A3FirmicutesLactobacillalesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_016206177.1Clostridium sartagoforme[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_016314690.1Paenibacillus barengoltzii[FeFe] Group A3FirmicutesBacillalesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin
WP_017416132.1Clostridium tunisiense[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_017416926.1Clostridium tunisiense[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_018084282.1Desulfurispora thermophila[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_018085930.1Desulfurispora thermophila[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 2 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_018086225.1Desulfurispora thermophila[FeFe] Group A3FirmicutesClostridialesBifurcatingLabile3[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin
WP_018249206.1Orenia marismortui[FeFe] Group A3FirmicutesHalanaerobialesBifurcatingLabile4[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH dehydrogenase, thioredoxin, thioredoxin

Literature

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