[FeFe] Group A2-hydrogenase Putative

This entry was last updated at: Sept. 12, 2016, 6:43 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group A2: Glutamate synthase-linked (putative)
Function Unconfirmed role. It may couple H2 oxidation to NAD reduction, generating reductant for glutamate synthase.
Activity H2-uptake?
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Encoded in anaerobic bacteria, including Firmicutes, Actinobacteria, and Proteobacteria
Genetic Organisation

e.g. Desulfovibrio vulgaris (WP_010939059.1):

Architecture
Structures
    None
Subunits 2
Subunit description HydA (catalytic subunit)
GltA (NADH-dependent glutamate synthase)
Catalytic site [FeFe]-centre
FeS clusters 3 [4Fe4S] clusters, 1 [2Fe2S] cluster
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_021726228.1Olsenella profusa[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_021739983.1Eubacterium ramulus[FeFe] Group A2FirmicutesClostridialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_021900643.1Eggerthella sp. CAG:1427[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_022094311.1Collinsella sp. CAG:166[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_022349260.1Collinsella sp. CAG:398[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_022362192.1Bacteroides pectinophilus[FeFe] Group A2BacteroidetesBacteroidalesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_022363186.1Eggerthella sp. CAG:298[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_022369673.1Eggerthella sp. CAG:368[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_022378933.1Cryptobacterium sp. CAG:338[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_022387742.1Collinsella sp. CAG:289[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_022444415.1Sutterella sp. CAG:351[FeFe] Group A2BetaproteobacteriaBurkholderialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_022472717.1Sutterella sp. CAG:521[FeFe] Group A2BetaproteobacteriaBurkholderialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_022741745.1Adlercreutzia equolifaciens[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_024622238.1Peptoclostridium mangenotii[FeFe] Group A2FirmicutesClostridialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_026783301.1Pleomorphomonas koreensis[FeFe] Group A2AlphaproteobacteriaRhizobialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_026790595.1Pleomorphomonas oryzae[FeFe] Group A2AlphaproteobacteriaRhizobialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_027174791.1Desulfovibrio aminophilus[FeFe] Group A2DeltaproteobacteriaDesulfovibrionalesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_027824154.1Laribacter hongkongensis[FeFe] Group A2BetaproteobacteriaNeisserialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_028027642.1Enterorhabdus mucosicola[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_028088444.1Dorea longicatena[FeFe] Group A2FirmicutesClostridialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_028264340.1Atopobium fossor[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_028529172.1Ruminococcus gauvreauii[FeFe] Group A2FirmicutesClostridialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_028533896.1Paludibacterium yongneupense[FeFe] Group A2BetaproteobacteriaNeisserialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_033162999.1Sharpea azabuensis[FeFe] Group A2FirmicutesLactobacillalesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase

Literature

Genetics: