This entry was last updated at: Sept. 12, 2016, 6:43 a.m.
Group | [FeFe]-hydrogenases |
Subgroup | [FeFe] Group A2: Glutamate synthase-linked (putative) |
Function | Unconfirmed role. It may couple H2 oxidation to NAD reduction, generating reductant for glutamate synthase. |
Activity | H2-uptake? |
Oxygen tolerance | O2-labile |
Localisation | Cytosolic |
Ecosystem distribution | Gastrointestinal tracts, anoxic soils and sediments |
Taxonomic distribution | Encoded in anaerobic bacteria, including Firmicutes, Actinobacteria, and Proteobacteria |
e.g. Desulfovibrio vulgaris (WP_010939059.1):
Structures |
|
Subunits | 2 |
Subunit description | HydA (catalytic subunit) GltA (NADH-dependent glutamate synthase) |
Catalytic site | [FeFe]-centre |
FeS clusters | 3 [4Fe4S] clusters, 1 [2Fe2S] cluster |
NCBI Accession | Organism | Hydrogenase Class | Phylum | Order | Activity (Predicted) | Oxygen Tolerance (Predicted) | Subunits (Predicted) | Metal Centres (Predicted) | Accessory Subunits (Predicted) |
---|---|---|---|---|---|---|---|---|---|
WP_007047054.1 | Subdoligranulum variabile | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_007156182.1 | Oribacterium sinus | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_008749893.1 | Lachnoanaerobaculum saburreum | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_008902548.1 | Peptoniphilus duerdenii | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_009146318.1 | Phascolarctobacterium succinatutens | [FeFe] Group A2 | Firmicutes | Selenomonadales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_009203940.1 | Anaerostipes hadrus | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_009536327.1 | Oribacterium asaccharolyticum | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_012738474.1 | Eubacterium eligens | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_012939287.1 | Acidaminococcus fermentans | [FeFe] Group A2 | Firmicutes | Selenomonadales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_013486154.1 | Ethanoligenens harbinense | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_014118796.1 | Oscillibacter valericigenes | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_015393386.1 | Clostridium saccharoperbutylacetonicum | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_015528722.1 | Lachnoclostridium torques | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_015572916.1 | Lachnoclostridium saccharolyticum | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_016147589.1 | Butyricicoccus pullicaecorum | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_020074005.1 | Ruminiclostridium sporosphaeroides | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_021739983.1 | Eubacterium ramulus | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_024622238.1 | Peptoclostridium mangenotii | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_028088444.1 | Dorea longicatena | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_028529172.1 | Ruminococcus gauvreauii | [FeFe] Group A2 | Firmicutes | Clostridiales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_033162999.1 | Sharpea azabuensis | [FeFe] Group A2 | Firmicutes | Lactobacillales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_010690649.1 | Treponema denticola | [FeFe] Group A2 | Spirochaetes | Spirochaetales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_013738980.1 | Sphaerochaeta coccoides | [FeFe] Group A2 | Spirochaetes | Spirochaetales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
WP_009165839.1 | Pyramidobacter piscolens | [FeFe] Group A2 | Synergistetes | Synergistales | Evolving | Labile | 2 | [FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] cluster | NADH-dependent glutamate synthase |
Genetics: