[FeFe] Group A2-hydrogenase Putative

This entry was last updated at: Sept. 12, 2016, 6:43 a.m.

Properties
Group [FeFe]-hydrogenases
Subgroup [FeFe] Group A2: Glutamate synthase-linked (putative)
Function Unconfirmed role. It may couple H2 oxidation to NAD reduction, generating reductant for glutamate synthase.
Activity H2-uptake?
Oxygen tolerance O2-labile
Localisation Cytosolic
Distribution
Ecosystem distribution Gastrointestinal tracts, anoxic soils and sediments
Taxonomic distribution Encoded in anaerobic bacteria, including Firmicutes, Actinobacteria, and Proteobacteria
Genetic Organisation

e.g. Desulfovibrio vulgaris (WP_010939059.1):

Architecture
Structures
    None
Subunits 2
Subunit description HydA (catalytic subunit)
GltA (NADH-dependent glutamate synthase)
Catalytic site [FeFe]-centre
FeS clusters 3 [4Fe4S] clusters, 1 [2Fe2S] cluster
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_002727095.1Phaeospirillum molischianum[FeFe] Group A2AlphaproteobacteriaRhodospirillalesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_009146318.1Phascolarctobacterium succinatutens[FeFe] Group A2FirmicutesSelenomonadalesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_026783301.1Pleomorphomonas koreensis[FeFe] Group A2AlphaproteobacteriaRhizobialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_026790595.1Pleomorphomonas oryzae[FeFe] Group A2AlphaproteobacteriaRhizobialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_006598813.1Pseudoramibacter alactolyticus[FeFe] Group A2FirmicutesClostridialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_009165839.1Pyramidobacter piscolens[FeFe] Group A2SynergistetesSynergistalesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_013499973.1Rhodopseudomonas palustris[FeFe] Group A2AlphaproteobacteriaRhizobialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_008382437.1Rhodovulum sp. PH10[FeFe] Group A2AlphaproteobacteriaRhodobacteralesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_020074005.1Ruminiclostridium sporosphaeroides[FeFe] Group A2FirmicutesClostridialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_028529172.1Ruminococcus gauvreauii[FeFe] Group A2FirmicutesClostridialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_033162999.1Sharpea azabuensis[FeFe] Group A2FirmicutesLactobacillalesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_006361310.1Slackia exigua[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_012798774.1Slackia heliotrinireducens[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_009139152.1Slackia piriformis[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_009078316.1Slackia sp. CM382[FeFe] Group A2ActinobacteriaCoriobacterialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_013738980.1Sphaerochaeta coccoides[FeFe] Group A2SpirochaetesSpirochaetalesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_007047054.1Subdoligranulum variabile[FeFe] Group A2FirmicutesClostridialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_008540631.1Sutterella parvirubra[FeFe] Group A2BetaproteobacteriaBurkholderialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_022444415.1Sutterella sp. CAG:351[FeFe] Group A2BetaproteobacteriaBurkholderialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_022472717.1Sutterella sp. CAG:521[FeFe] Group A2BetaproteobacteriaBurkholderialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_016474662.1Sutterella wadsworthensis[FeFe] Group A2BetaproteobacteriaBurkholderialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_010690649.1Treponema denticola[FeFe] Group A2SpirochaetesSpirochaetalesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_004611441.1Tyzzerella nexilis[FeFe] Group A2FirmicutesClostridialesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase
WP_018606045.1Uliginosibacterium gangwonense[FeFe] Group A2BetaproteobacteriaRhodocyclalesEvolvingLabile2[FeFe]-centre, 3 x [4Fe4S] clusters, 1 x [2Fe2S] clusterNADH-dependent glutamate synthase

Literature

Genetics: