[NiFe] Group 3c-hydrogenase

This entry was last updated at: June 13, 2016, 11:23 a.m.

Properties
Group [NiFe] Group 3: Cofactor-coupled bidirectional [NiFe] hydrogenases
Subgroup [NiFe] Group 3c: Heterodisulfide reductase-linked
Function Bifurcates electrons from H2 to heterodisulfide and ferredoxin. This is the final step in the Wolfe cycle of methanogenesis.
Activity Electron-bifurcation
Oxygen tolerance O2-tolerant?
Localisation Cytosolic
Distribution
Ecosystem distribution Methanogenic environments such as anoxic soils, marine sediments, and gastrointestinal tracts
Taxonomic distribution Encoded in most methanogens and sulfate-reducing bacteria
Genetic Organisation

e.g. Methanothermobacter marburgensis (WP_013296307.1):

Architecture
Structures
    None
Subunits 4
Subunit description MvhA (hydrogenase large subunit)
MvhG (hydrogenase small subunit)
MvhD (iron-sulfur subunit)
MvhB (polyferredoxin subunit)
Forms complex with heterodisulfide reductase (HdrABC)
Catalytic site [NiFe]-centre or [NiFeSe]-centre
FeS clusters Proximal: 4Cys[4Fe4S]
Medial: 4Cys[4Fe4S]
Distal: 4Cys[4Fe4S]
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_028584591.1Desulfobulbus mediterraneus[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_028583859.1Desulfobulbus mediterraneus[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015724435.1Desulfobulbus propionicus[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015722755.1Desulfobulbus propionicus[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_023408290.1Desulfofustis sp. PB-SRB1[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_022668938.1Desulfospira joergensenii[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_011188256.1Desulfotalea psychrophila[NiFe] Group 3cDeltaproteobacteriaDesulfobacteralesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013218178.1Dehalogenimonas lykanthroporepellens[NiFe] Group 3cChloroflexiDehalogenimonasBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_010936390.1Dehalococcoides mccartyi[NiFe] Group 3cChloroflexiDehalococcoidalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012302733.1Desulforudis audaxviator[NiFe] Group 3cFirmicutesClostridialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015617925.1Desulfotomaculum gibsoniae[NiFe] Group 3cFirmicutesClostridialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_006930005.1Caldithrix abyssi[NiFe] Group 3cCaldithrixCaldithrixalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_022775381.1Symbiobacter mobilis[NiFe] Group 3cBetaproteobacteriaBurkholderialesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_010878869.1Archaeoglobus fulgidus[NiFe] Group 3cEuryarchaeotaArchaeoglobalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_015590675.1Archaeoglobus sulfaticallidus[NiFe] Group 3cEuryarchaeotaArchaeoglobalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_013684228.1Archaeoglobus veneficus[NiFe] Group 3cEuryarchaeotaArchaeoglobalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein
WP_012965352.1Ferroglobus placidus[NiFe] Group 3cEuryarchaeotaArchaeoglobalesBifurcatingSensitive4[NiFe]-centre, 3 x [4Fe4S] clustersPolyferredoxin, [FeS] protein

Literature

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