[Fe]-hydrogenase

This entry was last updated at: June 15, 2016, 3:51 a.m.

Properties
Group [Fe]-hydrogenases
Subgroup N/A
Function Directly couples oxidation of H2 to reduction of 5,10-methenyltetrahydromethanopterin during hydrogenotrophic methanogenesis. Reverse reaction proposed to occur during formatotrophic methanogenesis.
Activity Bidirectional
Oxygen tolerance O2-tolerant
Localisation Cytosolic
Distribution
Ecosystem distribution Methanogenic environments such as anoxic soils, marine sediments, and gastrointestinal tracts
Taxonomic distribution Encoded in multiple methanogenic orders
Genetic Organisation

e.g. Methanothermobacter marburgensis (WP_013296316.1):

Architecture
Structures
  • 3DAG (Methanocaldococcus jannaschii, 1.8 Å resolution)
  • 2B0J (Methanocaldococcus jannaschii, 1.8 Å resolution)
  • 4JJF (Methanothermobacter marburgensis, 2.2 Å resolution)
  • 4JJG (Methanothermobacter marburgensis, 2.5 Å resolution)
Subunits 1
Subunit description HmdI (catalytic subunit)
Catalytic site [Fe]-guanylylpyridinol centre
FeS clusters Absent
Sequences in this class
NCBI AccessionOrganismHydrogenase ClassPhylumOrderActivity (Predicted)Oxygen Tolerance (Predicted)Subunits (Predicted)Metal Centres (Predicted)Accessory Subunits (Predicted)
WP_004030875.1Methanobacterium formicicum[Fe]EuryarchaeotaMethanobacterialesBidirectionalTolerant1Fe ionNone
WP_012955328.1Methanobrevibacter ruminantium[Fe]EuryarchaeotaMethanobacterialesBidirectionalTolerant1Fe ionNone
WP_019263574.1Methanobrevibacter smithii[Fe]EuryarchaeotaMethanobacterialesBidirectionalTolerant1Fe ionNone
WP_016357634.1Methanobrevibacter sp. AbM4[Fe]EuryarchaeotaMethanobacterialesBidirectionalTolerant1Fe ionNone
WP_015791545.1Methanocaldococcus fervens[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_013100253.1Methanocaldococcus infernus[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_010870290.1Methanocaldococcus jannaschii[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_012980975.1Methanocaldococcus sp. FS406-22[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_004591226.1Methanocaldococcus villosus[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_012819445.1Methanocaldococcus vulcanius[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_011973735.1Methanococcus aeolicus[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_011869295.1Methanococcus maripaludis[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_012065947.1Methanococcus vannielii[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_013180733.1Methanococcus voltae[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_011834108.1Methanocorpusculum labreanum[Fe]EuryarchaeotaMethanomicrobialesBidirectionalTolerant1Fe ionNone
WP_013329929.1Methanoplanus petrolearius[Fe]EuryarchaeotaMethanomicrobialesBidirectionalTolerant1Fe ionNone
WP_011018385.1Methanopyrus kandleri[Fe]EuryarchaeotaMethanopyralesBidirectionalTolerant1Fe ionNone
WP_015284887.1Methanoregula formicica[Fe]EuryarchaeotaMethanomicrobialesBidirectionalTolerant1Fe ionNone
WP_013296316.1Methanothermobacter marburgensis[Fe]EuryarchaeotaMethanobacterialesBidirectionalTolerant1Fe ionNone
WP_010876766.1Methanothermobacter thermautotrophicus[Fe]EuryarchaeotaMethanobacterialesBidirectionalTolerant1Fe ionNone
WP_013866724.1Methanothermococcus okinawensis[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_018153721.1Methanothermococcus thermolithotrophicus[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_013413799.1Methanothermus fervidus[Fe]EuryarchaeotaMethanobacterialesBidirectionalTolerant1Fe ionNone
WP_007044258.1Methanotorris formicicus[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone
WP_013799270.1Methanotorris igneus[Fe]EuryarchaeotaMethanococcalesBidirectionalTolerant1Fe ionNone

Literature

Genetics:

,

Physiology:

Biochemistry:

Chemistry: